eMedicine Specialties > Dermatology > Diseases of the Vessels

Wegener Granulomatosis: Multimedia

Author: Christen M Mowad, MD, Associate Professor, Department of Dermatology, Geisinger Medical Center
Coauthor(s): David Hensley, MD, Mullanax Dermatology Associates, Arlington Memorial Hospital; Lindsey Ann Dohse, MD, Staff Physician, Department of Dermatology, Geisinger Health System
Contributor Information and Disclosures

Updated: Jun 5, 2008

Multimedia

Large ulceration of the pharynx covered with a de...Media file 1: Large ulceration of the pharynx covered with a dense necrotic membrane.
Large ulceration of the pharynx covered with a de...

Large ulceration of the pharynx covered with a dense necrotic membrane.

Necrotic, purpuric, and blistering plaque on the...Media file 2: Necrotic, purpuric, and blistering plaque on the wrist.
Necrotic, purpuric, and blistering plaque on the...

Necrotic, purpuric, and blistering plaque on the wrist.

Several necrotic, purpuric, and blistering papule...Media file 3: Several necrotic, purpuric, and blistering papules and plaques on the hands.
Several necrotic, purpuric, and blistering papule...

Several necrotic, purpuric, and blistering papules and plaques on the hands.

More on Wegener Granulomatosis

Overview: Wegener Granulomatosis
Differential Diagnoses & Workup: Wegener Granulomatosis
Treatment & Medication: Wegener Granulomatosis
Follow-up: Wegener Granulomatosis
Multimedia: Wegener Granulomatosis
References

References

  1. Harper L, Savage CO. Pathogenesis of ANCA-associated systemic vasculitis. J Pathol. Feb 2000;190(3):349-59. [Medline].

  2. Erickson VR, Hwang PH. Wegener's granulomatosis: current trends in diagnosis and management. Curr Opin Otolaryngol Head Neck Surg. Jun 2007;15(3):170-6. [Medline].

  3. Mubashir E, Ahmed MM, Hayat S, Latif S, Heldmann M, Berney SM. Wegener granulomatosis: a case report and update. South Med J. Sep 2006;99(9):977-88. [Medline].

  4. Stegeman CA, Tervaert JW, Sluiter WJ, Manson WL, de Jong PE, Kallenberg CG. Association of chronic nasal carriage of Staphylococcus aureus and higher relapse rates in Wegener granulomatosis. Ann Intern Med. Jan 1 1994;120(1):12-7. [Medline].

  5. Savige J, Gillis D, Benson E, Davies D, Esnault V, Falk RJ, et al. International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies (ANCA). Am J Clin Pathol. Apr 1999;111(4):507-13. [Medline].

  6. Wung PK, Stone JH. Therapeutics of Wegener's granulomatosis. Nat Clin Pract Rheumatol. Apr 2006;2(4):192-200. [Medline].

  7. Antoniu SA. Treatment options for refractory Wegener's granulomatosis: a role for rituximab?. Curr Opin Investig Drugs. Nov 2007;8(11):927-32. [Medline].

  8. Nouraei SA, Obholzer R, Ind PW, Salama AD, Pusey CD, Porter F, et al. Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegener's granulomatosis. Thorax. Jan 2008;63(1):49-52. [Medline].

  9. Wegener's Granulomatosis Etanercept Trial (WGET) Research Group. Etanercept plus standard therapy for Wegener's granulomatosis. N Engl J Med. Jan 27 2005;352(4):351-61. [Medline].

  10. Barksdale SK, Hallahan CW, Kerr GS, Fauci AS, Stern JB, Travis WD. Cutaneous pathology in Wegener's granulomatosis. A clinicopathologic study of 75 biopsies in 46 patients. Am J Surg Pathol. Feb 1995;19(2):161-72. [Medline].

  11. Daoud MS, Gibson LE, DeRemee RA, Specks U, el-Azhary RA, Su WP. Cutaneous Wegener's granulomatosis: clinical, histopathologic, and immunopathologic features of thirty patients. J Am Acad Dermatol. Oct 1994;31(4):605-12. [Medline].

  12. [Best Evidence] De Groot K, Rasmussen N, Bacon PA, Tervaert JW, Feighery C, Gregorini G, et al. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. Aug 2005;52(8):2461-9. [Medline].

  13. Duna GF, Galperin C, Hoffman GS. Wegener's granulomatosis. Rheum Dis Clin North Am. Nov 1995;21(4):949-86. [Medline].

  14. Fauci AS. Wegener's granulomatosis. In: Fauci AS, Braunwald E, Isselbacher, eds. Harrison's Principles of Internal Medicine. 14th ed. New York, NY: McGraw-Hill; 1998:1914-7.

  15. Fauci AS, Gallo RC, Koenig S, Salk J, Purcell RH. NIH conference. Development and evaluation of a vaccine for human immunodeficiency virus (HIV) infection. Ann Intern Med. Mar 1 1989;110(5):373-85. [Medline].

  16. Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. Jan 1983;98(1):76-85. [Medline].

  17. Francès C, Du LT, Piette JC, Saada V, Boisnic S, Wechsler B, et al. Wegener's granulomatosis. Dermatological manifestations in 75 cases with clinicopathologic correlation. Arch Dermatol. Jul 1994;130(7):861-7. [Medline].

  18. Hellmich B, Lamprecht P, Gross WL. Advances in the therapy of Wegener's granulomatosis. Curr Opin Rheumatol. Jan 2006;18(1):25-32. [Medline].

  19. Hoffman GS, Kerr GS, Leavitt RY, Hallahan CW, Lebovics RS, Travis WD, et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med. Mar 15 1992;116(6):488-98. [Medline].

  20. Hogan SL, Falk RJ, Chin H, Cai J, Jennette CE, Jennette JC, et al. Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis. Ann Intern Med. Nov 1 2005;143(9):621-31. [Medline].

  21. Hu CH, O'Loughlin S, Winkelmann RK. Cutaneous manifestations of Wegener granulomatosis. Arch Dermatol. Feb 1977;113(2):175-82. [Medline].

  22. Jayne D, Rasmussen N, Andrassy K, Bacon P, Tervaert JW, Dadoniené J, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med. Jul 3 2003;349(1):36-44. [Medline].

  23. Jennette JC, Ewert BH, Falk RJ. Do antineutrophil cytoplasmic autoantibodies cause Wegener's granulomatosis and other forms of necrotizing vasculitis?. Rheum Dis Clin North Am. Feb 1993;19(1):1-14. [Medline].

  24. Jennette JC, Falk RJ. Antineutrophil cytoplasmic autoantibodies and associated diseases: a review. Am J Kidney Dis. Jun 1990;15(6):517-29. [Medline].

  25. Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. Feb 1994;37(2):187-92. [Medline].

  26. Jennette JC, Woosley JT, Falk RJ. Microscopic polyarteritis, Wegener's granulomatosis, and Churg-Strauss syndrome. J Cutan Med Surg. 1996;522-7.

  27. Lamprecht P, Voswinkel J, Lilienthal T, Nolle B, Heller M, Gross WL, et al. Effectiveness of TNF-alpha blockade with infliximab in refractory Wegener's granulomatosis. Rheumatology (Oxford). Nov 2002;41(11):1303-7. [Medline].

  28. Mangold MC, Callen JP. Cutaneous leukocytoclastic vasculitis associated with active Wegener's granulomatosis. J Am Acad Dermatol. Apr 1992;26(4):579-84. [Medline].

  29. Patten SF, Tomecki KJ. Wegener's granulomatosis: cutaneous and oral mucosal disease. J Am Acad Dermatol. May 1993;28(5 Pt 1):710-8. [Medline].

Further Reading

Keywords

Wegener's granulomatosis, WG

Contributor Information and Disclosures

Author

Christen M Mowad, MD, Associate Professor, Department of Dermatology, Geisinger Medical Center
Christen M Mowad, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Coauthor(s)

David Hensley, MD, Mullanax Dermatology Associates, Arlington Memorial Hospital
David Hensley, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Pennsylvania Medical Society, Southern Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.

Lindsey Ann Dohse, MD, Staff Physician, Department of Dermatology, Geisinger Health System
Lindsey Ann Dohse, MD is a member of the following medical societies: Alpha Omega Alpha
Disclosure: Nothing to disclose.

Medical Editor

Abby S Van Voorhees, MD, Assistant Professor, Director of Psoriasis Services and Phototherapy Units, Department of Dermatology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania
Abby S Van Voorhees, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, National Psoriasis Foundation, Phi Beta Kappa, Sigma Xi, and Women's Dermatologic Society
Disclosure: Amgen Honoraria Consulting; Astellas Grant/research funds Other; Abbott Honoraria Consulting; Genentech Honoraria Consulting; Incyte Grant/research funds Other; Centocor Honoraria Consulting; Warner Chilcott  Consulting; Merck Salary Review panel membership

Pharmacy Editor

David F Butler, MD, Professor of Dermatology, Texas A&M University College of Medicine; Director, Division of Dermatology, Scott and White Clinic; Director Dermatology Residency Training Program, Scott and White Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa
Disclosure: 3M Pharmaceutical Grant/research funds Other; Graceway Pharmaceuticals Grant/research funds Other

Managing Editor

Jeffrey P Callen, MD, Professor of Medicine, Chief, Division of Dermatology, University of Louisville School of Medicine
Jeffrey P Callen, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and American College of Rheumatology
Disclosure: Amgen Honoraria Consulting; Abbott Honoraria Consulting; Electrical Optical Sciences Honoraria Consulting; Centocor Honoraria Consulting

CME Editor

Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University
Catherine Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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