Medscape is available in 5 Language Editions – Choose your Edition here.


Tufted Angioma Follow-up

  • Author: Mitchel P Goldman, MD; Chief Editor: Dirk M Elston, MD  more...
Updated: Aug 17, 2015

Inpatient & Outpatient Medications

Outpatient medications may include topical steroids or oral NSAIDs for the treatment of painful episodes associated with tufted angioma.

Systemic corticosteroids and subcutaneous interferon alfa injections have been used with success in a limited number of patients with tufted angioma, although this indication is not formally approved by the US Food and Drug Administration.



Because the cause of tufted angioma is poorly understood, no specific method of prevention or deterrence is recommended.



Kasabach-Merritt syndrome or platelet-trapping syndrome may complicate the course of tufted angioma. Suspect Kasabach-Merritt syndrome in patients with tufted angioma in whom ecchymotic patches, thrombocytopenia, and/or blood-clotting abnormalities develop. Responses to a variety of appropriate treatment modalities are noted in patients with Kasabach-Merritt syndrome and tufted angioma.[17, 30]



Tufted angioma is a benign entity. No deaths directly or indirectly attributable to complications have been reported. However, pain and tenderness are common associated symptoms, and hyperhidrosis is a frequent finding that occurs in 30% of patients.[16]

The growth pattern of tufted angioma tends to be slow and progressive (ie, occurring over 5 mo to 10 y). However, an occasional tufted angioma undergoes a rapid expansion phase that leads to localized swelling and a decreased range of motion of the structures in the affected area. One report described a patient with a painful tufted angioma on the lateral neck and jaw. The tumor also had deep extension into the underlying fascia and muscle, a rare finding.[31]

Kasabach-Merritt syndrome (KMS), also known as platelet-trapping syndrome (PTS), occurs in association with tufted angioma in some patients. Fortunately, most of these patients have a favorable response to the treatment of platelet-trapping syndrome with aspirin and/or ticlopidine, oral betamethasone, or vincristine, without further sequelae.


Patient Education

Inform the patient and/or his or her parents of the benign nature of the condition, its slowly progressive course, rare regression, and occasional association with Kasabach-Merritt syndrome.

Contributor Information and Disclosures

Mitchel P Goldman, MD Voluntary Clinical Professor of Dermatology, University of California, San Diego, Medical Center; Dermatologist, Cosmetic Laser Dermatology

Mitchel P Goldman, MD is a member of the following medical societies: American College of Phlebology, Aerospace Medical Association, American Society of Lipo-Suction Surgery, Phi Beta Kappa, Dermatology Foundation, San Diego County Medical Society, American Academy of Cosmetic Surgery, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for Laser Medicine and Surgery, California Medical Association

Disclosure: Nothing to disclose.


Leyda E Bowes, MD Cosmetic Surgery Fellow, Department of Dermatology, Cosmetic Laser Associates of San Diego County

Leyda E Bowes, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Florida Medical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Michael J Wells, MD, FAAD Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

John G Albertini, MD Private Practice, The Skin Surgery Center; Clinical Associate Professor (Volunteer), Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine; President-Elect, American College of Mohs Surgery

John G Albertini, MD is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Surgery

Disclosure: Received grant/research funds from Genentech for investigator.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Carrie L Kovarik, MD Assistant Professor of Dermatology, Dermatopathology, and Infectious Diseases, University of Pennsylvania School of Medicine

Carrie L Kovarik, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

  1. Jones EW, Orkin M. Tufted angioma (angioblastoma). A benign progressive angioma, not to be confused with Kaposi's sarcoma or low-grade angiosarcoma. J Am Acad Dermatol. 1989 Feb. 20(2 Pt 1):214-25. [Medline].

  2. Nakagawa K. Case report of angioblastoma of the skin. Jpn J Dermatol. 1949. 59:92-4.

  3. Igarashi M, Oh-i T, Koga M. The relationship between angioblastoma (Nakagawa) and tufted angioma: report of four cases with angioblastoma and a literature-based comparison of the two conditions. J Dermatol. 2000 Aug. 27(8):537-42. [Medline].

  4. Ban M, Kamiya H, Kitajima Y. Tufted angioma of adult onset, revealing abundant eccrine glands and central regression. Dermatology. 2000. 201(1):68-70. [Medline].

  5. Dewerdt S, Callens A, Machet L, Grangeponte MC, Vaillant L, Lorette G. [Acquired tufted angioma in an adult: failure of pulsed dye laser therapy]. Ann Dermatol Venereol. 1998 Jan. 125(1):47-9. [Medline].

  6. Murakami M, Nitta Y, Ikeya T, Hara K. Two cases of angioblastoma (Nakagawa): A one-month baby and an 84-year-old man (in Japanese). Rinsho Derma (Tokyo). 1997. 39:925-9.

  7. Jang KA, Choi JH, Sung KJ, Moon KC, Koh JK. Congenital linear tufted angioma with spontaneous regression. Br J Dermatol. 1998 May. 138(5):912-3. [Medline].

  8. Ghosh SK, Bandyopadhyay D, Ghosh A, Biswas SK, Barma KD. Acquired multifocal tufted angiomas in an immunocompetent young adult. Indian J Dermatol. 2011 Jul. 56(4):412-4. [Medline]. [Full Text].

  9. Alberola FT, Betlloch I, Montero LC, Nortes IB, Martínez NL, Paz AM. Congenital tufted angioma: Case report and review of the literature. Dermatol Online J. 2010 May 15. 16(5):2. [Medline].

  10. Fukunaga M. Intravenous tufted angioma. APMIS. 2000 Apr. 108(4):287-92. [Medline].

  11. Kleinegger CL, Hammond HL, Vincent SD, Finkelstein MW. Acquired tufted angioma: a unique vascular lesion not previously reported in the oral mucosa. Br J Dermatol. 2000 Apr. 142(4):794-9. [Medline].

  12. Lam WY, Mac-Moune Lai F, Look CN, Choi PC, Allen PW. Tufted angioma with complete regression. J Cutan Pathol. 1994 Oct. 21(5):461-6. [Medline].

  13. Miyamoto T, Mihara M, Mishima E, Hagari Y, Shimao S. Acquired tufted angioma showing spontaneous regression. Br J Dermatol. 1992 Dec. 127(6):645-8. [Medline].

  14. Fujita H, Asahina A, Tamaki K. Extensive tufted angioma of the left arm in a 47-year-old woman. Clin Exp Dermatol. 2009 Oct. 34(7):e216-7. [Medline].

  15. McAleer MA, Kirby B, Sheahan K, Collins P. An erythematous patch and plaque on the shoulder--quiz case. Acquired tufted angioma (TA). Arch Dermatol. 2008 Sep. 144(9):1217-22. [Medline].

  16. Suarez SM, Pensler JM, Paller AS. Response of deep tufted angioma to interferon alfa. J Am Acad Dermatol. 1995 Jul. 33(1):124-6. [Medline].

  17. Enjolras O, Wassef M, Dosquet C, et al. [Kasabach-Merritt syndrome on a congenital tufted angioma]. Ann Dermatol Venereol. 1998 Apr. 125(4):257-60. [Medline].

  18. Swerlick RA, Cooper PH. Pyogenic granuloma (lobular capillary hemangioma) within port-wine stains. J Am Acad Dermatol. 1983 May. 8(5):627-30. [Medline].

  19. Alessi E, Bertani E, Sala F. Acquired tufted angioma. Am J Dermatopathol. 1986 Oct. 8(5):426-9. [Medline].

  20. Kim TH, Choi EH, Ahn SK, Lee SH. Vascular tumors arising in port-wine stains: two cases of pyogenic granuloma and a case of acquired tufted angioma. J Dermatol. 1999 Dec. 26(12):813-6. [Medline].

  21. Padilla RS, Orkin M, Rosai J. Acquired "tufted" angioma (progressive capillary hemangioma). A distinctive clinicopathologic entity related to lobular capillary hemangioma. Am J Dermatopathol. 1987 Aug. 9(4):292-300. [Medline].

  22. Kim YK, Kim HJ, Lee KG. Acquired tufted angioma associated with pregnancy. Clin Exp Dermatol. 1992 Nov. 17(6):458-9. [Medline].

  23. Schaffer JV, Fangman W, Bossenbroek NM, Meehan SA, Kamino H. Tufted angioma. Dermatol Online J. 2008 Oct 15. 14(10):20. [Medline].

  24. Jones EW. Dowling oration 1976. Malignant vascular tumours. Clin Exp Dermatol. 1976 Dec. 1(4):287-312. [Medline].

  25. Prieto VG, Shea CR. Selected cutaneous vascular neoplasms. A review. Dermatol Clin. 1999 Jul. 17(3):507-20, viii. [Medline].

  26. Barco D, Baselga E, Ribe A, Alomar A. [Congenital self-limiting tufted angioma]. Actas Dermosifiliogr. 2008 Jun. 99(5):423-5. [Medline].

  27. Descours H, Grézard P, Chouvet B, Labeille B. [Acquired tufted angioma in an adult]. Ann Dermatol Venereol. 1998 Jan. 125(1):44-6. [Medline].

  28. Munn SE, Jackson JE, Jones RR. Tufted haemangioma responding to high-dose systemic steroids: a case report and review of the literature. Clin Exp Dermatol. 1994 Nov. 19(6):511-4. [Medline].

  29. Bernstein EF, Kantor G, Howe N, Savit RM, Koblenzer PJ, Uitto J. Tufted angioma of the thigh. J Am Acad Dermatol. 1994 Aug. 31(2 Pt 2):307-11. [Medline].

  30. Leaute-Labreze C, Bioulac-Sage P, Labbe L, Meraud JP, Taieb A. Tufted angioma associated with platelet trapping syndrome: response to aspirin. Arch Dermatol. 1997 Sep. 133(9):1077-9. [Medline].

  31. Silva RS, Bressan AL, Nascimento LB, Kac BK, Azulay-Abulafia L. Tufted angioma and myofascial pain syndrome. An Bras Dermatol. 2011 Feb. 86(1):125-7. [Medline].

This lesion is a tufted angioma in a 1-year-old girl. Present since birth, this bluish-red hemangioma-like plaque on the patient's right upper leg slowly enlarged and became tender during the month prior to presentation. The child was otherwise well. A skin biopsy specimen revealed dilated congested capillaries in the lower dermis and subcutis. Clusters of capillaries with hyperplastic endothelial cells were also scattered in the mid and upper parts of the dermis. The epidermis revealed a slight basket-weave orthokeratosis, with minimal acanthosis, and papillomatosis. The patient was treated conservatively with only observation. The lesion remained stable and did not progressed since presentation. Courtesy of National Skin Centre, Singapore.
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.