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Benign Lymphangioendothelioma Follow-up

  • Author: Donald Shenenberger, MD, FAAD, FAAFP; Chief Editor: Dirk M Elston, MD  more...
 
Updated: Oct 06, 2015
 

Further Outpatient Care

Because of the histologic confusion at times between benign lymphangioendothelioma (BLAE), angiosarcoma, and Kaposi sarcoma, annual follow-up to assess for recurrence is recommended.

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Complications

Complications are usually only those associated with surgery and laser treatment, such as scarring and pigmentary change.

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Prognosis

The prognosis is excellent.

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Patient Education

Inform patients they have a rare (though benign) vascular tumor that is poorly understood, and annual screening is recommended.

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Contributor Information and Disclosures
Author

Donald Shenenberger, MD, FAAD, FAAFP Virginia Dermatology and Skin Cancer Center; Assistant Professor of Dermatology, Eastern Virginia Medical School

Donald Shenenberger, MD, FAAD, FAAFP is a member of the following medical societies: American Academy of Dermatology, American Academy of Family Physicians, Association of Military Dermatologists, Uniformed Services Academy of Family Physicians

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Rosalie Elenitsas, MD Herman Beerman Professor of Dermatology, University of Pennsylvania School of Medicine; Director, Penn Cutaneous Pathology Services, Department of Dermatology, University of Pennsylvania Health System

Rosalie Elenitsas, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society of Dermatopathology, Pennsylvania Academy of Dermatology

Disclosure: Received royalty from Lippincott Williams Wilkins for textbook editor.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Gregory J Raugi, MD, PhD Professor, Department of Internal Medicine, Division of Dermatology, University of Washington at Seattle School of Medicine; Chief, Dermatology Section, Primary and Specialty Care Service, Veterans Administration Medical Center of Seattle

Gregory J Raugi, MD, PhD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Acknowledgements

Walter HC Burgdorf, MD Clinical Lecturer, Department of Dermatology, Ludwig Maximilian University, Munich, Germany

Walter HC Burgdorf, MD is a member of the following medical societies: American Academy of Dermatology, American Dermatological Association, American Society of Dermatopathology, International Society of Dermatopathology, and Society for Pediatric Dermatology

Disclosure: Nothing to disclose.

References
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  2. Requena L, Sangueza OP. Cutaneous vascular proliferation. Part II. Hyperplasias and benign neoplasms. J Am Acad Dermatol. 1997 Dec. 37(6):887-919; quiz 920-2. [Medline].

  3. Jones EW, Winkelmann RK, Zachary CB, Reda AM. Benign lymphangioendothelioma. J Am Acad Dermatol. 1990 Aug. 23(2 Pt 1):229-35. [Medline].

  4. Messeguer F, Sanmartín O, Martorell-Calatayud A, Nagore E, Requena C, Guillen-Barona C. [Acquired progressive lymphangioma (benign lymphangioendothelioma)]. Actas Dermosifiliogr. 2010 Nov. 101(9):792-7. [Medline].

  5. Revelles JM, Díaz JL, Angulo J, Santonja C, Kutzner H, Requena L. Giant benign lymphangioendothelioma. J Cutan Pathol. 2012 Oct. 39 (10):950-6. [Medline].

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  7. Kim HS, Kim JW, Yu DS. Acquired progressive lymphangioma. J Eur Acad Dermatol Venereol. 2007 Mar. 21(3):416-7. [Medline].

  8. Fernandez-Flores A. Benign lymphangioendothelioma. Dermatopathonline. Available at http://www.dermatopathonline.com/lymphangioendothelioma2.html. Accessed: February 24, 2013.

  9. Kato H, Kadoya A. Acquired progressive lymphangioma occurring following femoral arteriography. Clin Exp Dermatol. 1996 Mar. 21(2):159-62. [Medline].

  10. Paik AS, Lee PH, O'Grady TC. Acquired progressive lymphangioma in an HIV-positive patient. J Cutan Pathol. 2007 Nov. 34(11):882-5. [Medline].

  11. Herron GS, Rouse RV, Kosek JC, Smoller BR, Egbert BM. Benign lymphangioendothelioma. J Am Acad Dermatol. 1994 Aug. 31(2 Pt 2):362-8. [Medline].

  12. Watanabe M, Kishiyama K, Ohkawara A. Acquired progressive lymphangioma. J Am Acad Dermatol. 1983 May. 8(5):663-7. [Medline].

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Erythematous nodule with macular component at the periphery.
Overview of a histologic section from a tumor depicting dilated vascular spaces interspersed between collagen fibers and a more central accumulation of many complex vascular spaces.
High-power view showing dilated vascular channel with innocent endothelial cells.
High-power view showing lymphatic endothelial cells in a hematoxylin and eosin–stained section.
High-power view showing lymphatic endothelial cells stained positively with podoplanin.
 
 
 
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