Fire Ant Bites Follow-up

  • Author: James P Ralston, MD; Chief Editor: Rick Kulkarni, MD   more...
 
Updated: Jan 23, 2012
 

Inpatient & Outpatient Medications

  • Desensitization may be helpful to protect patients who are allergic from reactions to future stings. This type of immunotherapy has been used for almost 30 years to prevent the recurrence of anaphylaxis.[3]
    • Treatment consists of weekly subcutaneous injections of increasing doses of whole-body vaccine until a predetermined maintenance dose is reached (usually 0.5 mL of a 1:10 dilution of the 1:10 weight/volume stock whole-body vaccine solution). Maintenance doses are typically administered every 4-6 weeks.
    • Immunotherapy for children with isolated skin reactions to fire ant stings is controversial because of a lack of data.[4] Most allergists do not routinely recommend immunotherapy for this population, but some do because of the great risk of stings in endemic areas.
  • Prescribe an anaphylactic kit (ANA kit) or Epi-Pen, if indicated.[4]
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Deterrence/Prevention

  • Avoidance of fire ants is important in the management of patients with fire ant hypersensitivity. Avoidance is facilitated by the following:
    • Having professionals evaluate the patient's home for stinging insect nests and fire ant mounds, and, if found, exterminating these nests and mounds
    • Not wearing brightly colored clothing or strongly scented lotions
    • Wearing shoes (not sandals) when walking outside
    • Being cautious around bushes, attics, picnic areas, or garbage containers
    • Keeping insecticides readily available
    • Wearing long pants, a long-sleeved shirt, socks, shoes, a hat, and work gloves when working outside
  • Attempts to control fire ant populations in endemic areas have included the use of chemical pesticides and novel biological control, including the use of decapitating flies. Decapitating flies (ie, Pseudacteon tricuspis, Pseudacteon curvatus, Pseudacteon littoralis) from South America have been released in the United States. These flies deposit an egg in the thorax of worker fire ants. The egg hatches and the larvae move toward the head, where they eat the ant's glands and muscles and release an enzyme that makes the ant's head fall off.[5]
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Complications

  • Systemic allergic reactions are a potential complication of fire ant stings.
  • Secondary infection of the sting site with possible pyoderma or sepsis can occur.
  • Fatal toxic reactions from ant stings have been reported in small animals, but no human fatalities from toxic reactions have been reported.
    • Toxic reactions have been considered as possible factors in deaths occurring in immobilized, chronically ill subjects stung by fire ants, but toxicologic studies of fire ant venom effects in humans have not been performed.
    • It seems unlikely that the venom toxicity alone explains these deaths because patients who are not allergic have endured thousands of stings with no complications other than pustules.
  • Seizures and mononeuropathy are rare but have been reported.
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Prognosis

  • Minor reactions have an excellent prognosis.
  • Severe reactions have an excellent prognosis with early and appropriate treatment.
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Patient Education

  • Patient education is essential in preventing possible life-threatening reactions in patients who are allergic and in providing appropriate treatment of such reactions if they occur. This should include the following:
    • Identification of stinging insects
    • Knowledge of how to avoid being stung
    • Knowledge of how and when to self-administer epinephrine, if indicated
    • Carrying proper identification of stinging insect hypersensitivity (eg, Medic Alert bracelet)
  • For excellent patient education resources, visit eMedicine's Bites and Stings Center. Also, see eMedicine's patient education articles Insect Bites, Allergy: Insect Sting, and Severe Allergic Reaction (Anaphylactic Shock).
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Contributor Information and Disclosures
Author

James P Ralston, MD  President, Dermatology Center of McKinney

James P Ralston, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, and Texas Medical Association

Disclosure: Nothing to disclose.

Coauthor(s)

Ronald P Rapini, MD  Josey Professor and Chair, Department of Dermatology, Professor of Pathology, University of Texas Medical School at Houston and MD Anderson Cancer Center

Ronald P Rapini, MD is a member of the following medical societies: American Academy of Dermatology, American Dermatological Association, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Society for Investigative Dermatology, and Texas Medical Association

Disclosure: Elsevier publishers Royalty Independent contractor

Specialty Editor Board

Daniel J Hogan, MD  Clinical Professor of Internal Medicine (Dermatology), Nova Southeastern University College of Osteopathic Medicine; Investigator, Hill Top Research, Florida Research Center

Daniel J Hogan, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Contact Dermatitis Society, and Canadian Dermatology Association

Disclosure: Nothing to disclose.

Michael J Wells, MD  Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

Jeffrey J Miller, MD  Associate Professor of Dermatology, Pennsylvania State University College of Medicine; Staff Dermatologist, Pennsylvania State Milton S Hershey Medical Center

Jeffrey J Miller, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Association of Professors of Dermatology, North American Hair Research Society, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Joel M Gelfand, MD, MSCE  Medical Director, Clinical Studies Unit, Assistant Professor, Department of Dermatology, Associate Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania

Joel M Gelfand, MD, MSCE is a member of the following medical societies: Society for Investigative Dermatology

Disclosure: AMGEN Consulting fee Consulting; AMGEN Grant/research funds Investigator; Genentech Grant/research funds investigator; Centocor Consulting fee Consulting; Abbott Grant/research funds investigator; Abbott Consulting fee Consulting; Novartis investigator; Pfizer Grant/research funds investigator; Celgene Consulting fee DMC Chair; NIAMS and NHLBI Grant/research funds investigator

Chief Editor

Rick Kulkarni, MD  Attending Physician, Department of Emergency Medicine, Cambridge Health Alliance, Division of Emergency Medicine, Harvard Medical School

Rick Kulkarni, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine

Disclosure: WebMD Salary Employment

References
  1. Hoffman DR. Ant venoms. Curr Opin Allergy Clin Immunol. Aug 2010;10(4):342-6. [Medline].

  2. More DR, Kohlmeier RE, Hoffman DR. Fatal anaphylaxis to indoor native fire ant stings in an infant. Am J Forensic Med Pathol. Mar 2008;29(1):62-3. [Medline].

  3. La Shell MS, Calabria CW, Quinn JM. Imported fire ant field reaction and immunotherapy safety characteristics: the IFACS study. J Allergy Clin Immunol. Jun 2010;125(6):1294-9. [Medline].

  4. [Guideline] Moffitt JE, Golden DB, Reisman RE, Lee R, Nicklas R, Freeman T, et al. Stinging insect hypersensitivity: a practice parameter update. J Allergy Clin Immunol. Oct 2004;114(4):869-86. [Medline]. [Full Text].

  5. Williams DF, deShazo RD. Biological control of fire ants: an update on new techniques. Ann Allergy Asthma Immunol. Jul 2004;93(1):15-22. [Medline].

  6. Burroughs R, Elston DM. What's eating you? Fire ants. Cutis. Feb 2005;75(2):85-9. [Medline].

  7. Champion RH, Burton JL, Burns DA. Rook/Wilkinson/Ebling Textbook of Dermatology. Vol 2. 6th ed. London, England: Blackwell Science; 1998:1436-7.

  8. Cotran RS, Kumar V, Collins T, eds. Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, Pa: WB Saunders; 1999:1212.

  9. Dambro MR, Griffith JA. Griffith's 5-Minute Clinical Consult. Philadelphia, Pa: Lippincott Williams & Wilkins; 1999:570-1.

  10. Ellis AK, Day JH. Clinical reactivity to insect stings. Curr Opin Allergy Clin Immunol. Aug 2005;5(4):349-54. [Medline].

  11. Ford JL, Dolen WK, Feger TA, Hoffman DR, Stafford CT. Evaluation of an in vitro assay for fire ant venom-specific IgE. J Allergy Clin Immunol. Sep 1997;100(3):425-7. [Medline].

  12. Freedberg IM, Eisen AZ, Wolff K, eds. Fitzpatrick's Dermatology in General Medicine. Vol 2. 5th ed. New York, NY: McGraw-Hill; 1999:2693-5.

  13. Goddard J, Jarratt J, de Castro FR. Evolution of the fire ant lesion. JAMA. Nov 1 2000;284(17):2162-3. [Medline].

  14. Hoffman DR. Reactions to less common species of fire ants. J Allergy Clin Immunol. Nov 1997;100(5):679-83. [Medline].

  15. Jerrard DA. ED management of insect stings. Am J Emerg Med. Jul 1996;14(4):429-33. [Medline].

  16. Kemp SF, deShazo RD, Moffitt JE, Williams DF, Buhner WA. Expanding habitat of the imported fire ant (Solenopsis invicta): a public health concern. J Allergy Clin Immunol. Apr 2000;105(4):683-91. [Medline].

  17. Lee TH, Comes S, Burgos T. ePocrates qRx. ePocrates Inc. Available at http://www.epocrates.com/. Accessed 2000.

  18. Odom RB, James WD, Berger TG. Andrews' Diseases of the Skin: Clinical Dermatology. 9th ed. Philadelphia, Pa: WB Saunders; 2000:559.

  19. Ownby DR. Pediatric anaphylaxis, insect stings, and bites. Immunol Allergy Clin North Am. 1999;19 (2):347-61.

  20. Rakel RE. Conn's Current Therapy 2000. 52nd ed. Philadelphia, Pa: WB Saunders; 2000:753-5.

  21. Smith KE, Fenske NA. Cutaneous manifestations of alcohol abuse. J Am Acad Dermatol. Jul 2000;43(1 Pt 1):1-16; quiz 16-8. [Medline].

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Imported fire ant national distribution map. From http://fireant.tamu.edu. Reproduced with permission from B.M. Drees, Texas Imported Fire Ant Project Coordinator, Texas A&M University, College Station, Texas.
Red imported fire ant worker. From http://fireant.tamu.edu. Reproduced with permission from B.M. Drees, Texas Imported Fire Ant Project Coordinator, Texas A&M University, College Station, Texas.
Fire ant mound in lawn. From http://fireant.tamu.edu. Reproduced with permission from B.M. Drees, Texas Imported Fire Ant Project Coordinator, Texas A&M University, College Station, Texas.
Venom sac and stinger of a fire ant. From http://fireant.tamu.edu. Reproduced with permission from B.M. Drees, Texas Imported Fire Ant Project Coordinator, Texas A&M University, College Station, Texas.
Fire ant worker biting and stinging. From http://fireant.tamu.edu. Reproduced with permission from B.M. Drees, Texas Imported Fire Ant Project Coordinator, Texas A&M University, College Station, Texas.
Pustules and blisters formed following fire ant stings on the arm. From http://fireant.tamu.edu. Reproduced with permission from B.M. Drees, Texas Imported Fire Ant Project Coordinator, Texas A&M University, College Station, Texas.
Pustules and blisters formed following fire ant stings on the hand. From http://fireant.tamu.edu. Reproduced with permission from B.M. Drees, Texas Imported Fire Ant Project Coordinator, Texas A&M University, College Station, Texas.
Fire ant bites on the foot.
 
 
 
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