Cutaneous Candidiasis Differential Diagnoses

  • Author: Noah S Scheinfeld, MD, JD, FAAD; Chief Editor: William D James, MD   more...
 
Updated: Aug 2, 2011
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Noah S Scheinfeld, MD, JD, FAAD  Assistant Clinical Professor, Department of Dermatology, Columbia University College of Physicians and Surgeons; Consulting Staff, Department of Dermatology, St Luke's Roosevelt Hospital Center, Beth Israel Medical Center, and New York Eye and Ear Infirmary; Private Practice

Noah S Scheinfeld, MD, JD, FAAD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Optigenex Consulting fee Independent contractor

Coauthor(s)

Matthew C Lambiase, DO  Dermatologist, Skin Cancer and Dermatology Institute, Reno, NV

Disclosure: Nothing to disclose.

Daniel S Lehman, MD  Fellow in Minimally Invasive Urology/Oncology, Department of Urology, Columbia University Medical Center

Disclosure: Nothing to disclose.

Jessica M Allan, MD  Consulting Staff, Private Practice

Disclosure: Nothing to disclose.

Specialty Editor Board

Franklin Flowers, MD  Chief, Division of Dermatology, Professor, Department of Medicine and Otolaryngology, Affiliate Associate Professor of Pediatrics and Pathology, University of Florida College of Medicine

Franklin Flowers, MD, is a member of the following medical societies: American College of Mohs Micrographic Surgery and Cutaneous Oncology

Disclosure: Nothing to disclose.

Richard P Vinson, MD  Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association

Disclosure: Nothing to disclose.

Paul Krusinski, MD  Director of Dermatology, Fletcher Allen Health Care; Professor, Department of Internal Medicine, University of Vermont College of Medicine

Paul Krusinski, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD  Paul R Gross Professor of Dermatology, University of Pennsylvania School of Medicine; Vice-Chair, Program Director, Department of Dermatology, University of Pennsylvania Health System

William D James, MD is a member of the following medical societies: American Academy of Dermatology and Society for Investigative Dermatology

Disclosure: Elsevier Royalty Other

Additional Contributors

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous author, Thomas Vaughan, MD, to the development and writing of this article.

References

  1. Li M, Chen Q, Shen Y, Liu W. Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2. Exp Dermatol. Jul 2009;18(7):603-10. [Medline].

  2. Shiraki Y, Ishibashi Y, Hiruma M, Nishikawa A, Ikeda S. Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. FEMS Immunol Med Microbiol. Oct 2008;54(1):122-8. [Medline].

  3. Foureur N, Vanzo B, Meaume S, Senet P. Prospective aetiological study of diaper dermatitis in the elderly. Br J Dermatol. Nov 2006;155(5):941-6. [Medline].

  4. Kränke B, Trummer M, Brabek E, Komericki P, Turek TD, Aberer W. Etiologic and causative factors in perianal dermatitis: results of a prospective study in 126 patients. Wien Klin Wochenschr. Mar 2006;118(3-4):90-4. [Medline].

  5. Nardin ME, Pelegri DG, Manias VG, Méndez Ede L. [Etiological agents of dermatomycoses isolated in a hospital of Santa Fe City, Argentina]. Rev Argent Microbiol. Jan-Mar 2006;38(1):25-7. [Medline].

  6. Nishimoto K. [An epidemiological survey of dermatomycoses in Japan, 2002]. Nippon Ishinkin Gakkai Zasshi. 2006;47(2):103-11. [Medline].

  7. Peñate Y, Guillermo N, Melwani P, Martel R, Borrego L. Dermatologists in hospital wards: an 8-year study of dermatology consultations. Dermatology. 2009;219(3):225-31. [Medline].

  8. Ramirez De Knott HM, McCormick TS, Do SO, et al. Cutaneous hypersensitivity to Candida albicans in idiopathic vulvodynia. Contact Dermatitis. Oct 2005;53(4):214-8. [Medline].

  9. Gibney MD, Siegfried EC. Cutaneous congenital candidiasis: a case report. Pediatr Dermatol. Dec 1995;12(4):359-63. [Medline].

  10. Raval DS, Barton LL, Hansen RC, Kling PJ. Congenital cutaneous candidiasis: case report and review. Pediatr Dermatol. Dec 1995;12(4):355-8. [Medline].

  11. Hoppe JE. Treatment of oropharyngeal candidiasis and candidal diaper dermatitis in neonates and infants: review and reappraisal. Pediatr Infect Dis J. Sep 1997;16(9):885-94. [Medline].

  12. Ramos-E-Silva M, Lima CM, Schechtman RC, Trope BM, Carneiro S. Superficial mycoses in immunodepressed patients (AIDS). Clin Dermatol [serial online]. 2010 Mar 4;28(2);217-25. [Medline]. Available at http://www.ncbi.nlm.nih.gov/pubmed/20347666.

  13. Nico MM, Rivitti EA. 'Decubital candidosis': a study of 26 cases. J Eur Acad Dermatol Venereol. May 2005;19(3):296-300. [Medline].

  14. Aly R, Berger T. Common superficial fungal infections in patients with AIDS. Clin Infect Dis. May 1996;22 Suppl 2:S128-32. [Medline].

  15. Marquart KH. Electron microscopy reveals fungal cells within tumor tissue from two African patients with AIDS-associated Kaposi sarcoma. Ultrastruct Pathol. May-Jun 2006;30(3):187-92. [Medline].

  16. Wang SM, Yang YJ, Chen JS, Lin HC, Chi CY, Liu CC. Invasive fungal infections in pediatric patients with leukemia: emphasis on pulmonary and dermatological manifestations. Acta Paediatr Taiwan. May-Jun 2005;46(3):149-55. [Medline].

  17. Yanagisawa N, Suganuma A, Takeshita N, et al. [A case of disseminated candidiasis as an initial presentation of AIDS]. Kansenshogaku Zasshi. Jul 2007;81(4):459-62. [Medline].

  18. Andrews JI, Fleener DK, Messer SA, Hansen WF, Pfaller MA, Diekema DJ. The yeast connection: is Candida linked to breastfeeding associated pain?. Am J Obstet Gynecol. Oct 2007;197(4):424.e1-4. [Medline].

  19. Agarwal S, Sharma M, Mehndirata V. Solitary ecthyma gangrenosum (EG)-like lesion consequent to Candida albicans in a neonate. Indian J Pediatr. Jun 2007;74(6):582-4. [Medline].

  20. Xi L, Li X, Zhang J, Lu C, Xie T, Yin R. Good response in a patient with deep-seated subcutaneous ulcer due to Candida species. Mycopathologia. Aug 2007;164(2):77-80. [Medline].

  21. Luo DQ, Yang W, Wu LC, Liu JH, Chen WN. Interdigital ulcer: an unusual presentation of Candida infection. Mycoses. May 25 2011;[Medline].

  22. Geddes ER, Polder K, Cutlan JE, Torres-Cabala CA, Hymes SR. Ulcerated plaque under a ruby ring in an immunosuppressed patient. Dermatol Online J. Aug 15 2010;16(8):4. [Medline].

  23. Diana A, Epiney M, Ecoffey M, Pfister RE. "White dots on the placenta and red dots on the baby": congential cutaneous candidiasis--a rare disease of the neonate. Acta Paediatr. Jul 2004;93(7):996-9. [Medline].

  24. Williams MD, Sallee D, Robinson M. Diabetic ketoacidosis in toddler with a diaper rash. Am J Emerg Med. Sep 2008;26(7):834.e1-2. [Medline].

  25. Lim CS, Lim SL. New contrast stain for the rapid diagnosis of dermatophytic and candidal dermatomycoses. Arch Dermatol. Sep 2008;144(9):1228-9. [Medline].

  26. Sundaram SV, Srinivas CR, Thirumurthy M. Candidal intertrigo: treatment with filter paper soaked in Castellani's paint. Indian J Dermatol Venereol Leprol. Sep-Oct 2006;72(5):386-7. [Medline].

  27. Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. Mar 1 2009;48(5):503-35. [Medline].

  28. Duong T, Ingen-Housz-Oro S, Gaulier A, Petit A, Dubertret L, Sigal-Grinberg M. [Extensive cutaneous candidiasis revealing cutaneous T-cell lymphoma: 2 cases]. Ann Dermatol Venereol. Jun-Jul 2006;133(6-7):566-70. [Medline].

  29. Aridogan IA, Ilkit M, Izol V, Ates A. Malassezia and Candida colonisation on glans penis of circumcised men. Mycoses. Sep 2005;48(5):352-6. [Medline].

  30. Elewski BE. Cutaneous mycoses in children. Br J Dermatol. Jun 1996;134 Suppl 46:7-11: discussion 37-8. [Medline].

  31. Fotos PG, Lilly JP. Clinical management of oral and perioral candidosis. Dermatol Clin. Apr 1996;14(2):273-80. [Medline].

  32. Gilbert DN, Moellering RC, Merle AS. Sanford Guide to Antimicrobial Therapy. 35th ed. 2005.

  33. Hay RJ. Yeast infections. Dermatol Clin. Jan 1996;14(1):113-24. [Medline].

  34. Hedderwick S, Kauffman CA. Opportunistic fungal infections: superficial and systemic candidiasis. Geriatrics. Oct 1997;52(10):50-4, 59. [Medline].

  35. Rang HP, Dale MM, et al. Pharmacology. 689-90. New York, NY: Churchill Livingstone; 1995:756-60.

  36. Seebacher C, Abeck D, Brasch J, et al. [Candidiasis of the skin]. J Dtsch Dermatol Ges. Jul 2006;4(7):591-6. [Medline].

  37. Smolinski KN, Shah SS, Honig PJ, Yan AC. Neonatal cutaneous fungal infections. Curr Opin Pediatr. Aug 2005;17(4):486-93. [Medline].

  38. Takechi M. Minimum effective dosage in the treatment of chronic atopic dermatitis with itraconazole. J Int Med Res. May-Jun 2005;33(3):273-83. [Medline].

  39. Warren NG. Taxonomy and introduction. Dermatol Clin. Jan 1996;14(1):1-7. [Medline].

 
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A moist, erosive, pruritic patch of the perianal skin and perineum (with satellite pustule formation) is demonstrated in this woman with extensive candidosis.
Discrete superficial pustules developed within hours of birth on the hand of an otherwise healthy newborn. A potassium hydroxide preparation revealed spores and pseudomycelium, and culture demonstrated the presence of Candida albicans.
Dry, red, superficially scaly, pruritic macules and patches on the penis represent candidal balanitis.
White plaques are present on the buccal mucosa and the undersurface of the tongue and represent thrush. When wiped off, the plaques leave red erosive areas.
Erythema, maceration, and satellite pustules in the axilla, accompanied by soreness and pruritus result in a form of intertrigo.
A nailfold with candidal infection becomes erythematous, swollen, and tender with an occasional discharge
Soreness and cracks at the lateral angles of the mouth (angular cheilitis) is a frequent expression of candidosis in elderly individuals.
Fine superficial pustules on an erythematous patchy base are suggestive of candidosis.
Candida infection should be in the differential diagnosis when one or more nails become discolored, has subungual discoloration, nailplate separation from the nailbed, and lack evidence of a dermatophyte.
Candidiasis. Courtesy of Hon Pak, MD.
 
 
 
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