Eumycetoma (Fungal Mycetoma) Medication

  • Author: George Turiansky, MD; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jan 30, 2012
 

Medication Summary

The use of various antifungal agents in the treatment of eumycetoma has been reported. Imidazole antifungal agents appear to be the agents of choice. Of the azole group of antifungal agents, ketoconazole appears to be antifungal agent of choice, although isolated reports of successful treatment with itraconazole exist.

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Antifungal Agents

Class Summary

Reportedly, imidazole antifungal agents are variably effective in the treatment of eumycetoma when they are used alone or in conjunction with surgical therapy.

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Ketoconazole (Nizoral)

 

Synthetic imidazole antifungal agent. Broad-spectrum agent known to be a potent inhibitor of cytochrome P-450 3A4 enzyme system in vitro. Inhibition of this system impairs synthesis of ergosterol, a vital component of fungal cell membranes.

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Itraconazole (Sporanox)

 

Triazole antifungal agent known to be a potent inhibitor of the cytochrome P-450–dependent synthesis of ergosterol in vitro. Slows fungal cell growth by inhibiting cytochrome P-450–dependent synthesis of ergosterol, a vital component of fungal cell membranes.

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Contributor Information and Disclosures
Author

George Turiansky, MD  Professor, Department of Dermatology, Uniformed Services University of the Health Sciences; Deputy Director, National Capital Consortium, Graduate Medical Education, Uniformed Services University of the Health Sciences

George Turiansky, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Association of Military Dermatologists, Association of Professors of Dermatology, and Ukrainian Medical Association of North America

Disclosure: Nothing to disclose.

Specialty Editor Board

Daniel J Hogan, MD  Clinical Professor of Internal Medicine (Dermatology), Nova Southeastern University College of Osteopathic Medicine; Investigator, Hill Top Research, Florida Research Center

Daniel J Hogan, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Contact Dermatitis Society, and Canadian Dermatology Association

Disclosure: Nothing to disclose.

Michael J Wells, MD  Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

Paul Krusinski, MD  Director of Dermatology, Fletcher Allen Health Care; Professor, Department of Internal Medicine, University of Vermont College of Medicine

Paul Krusinski, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD  Director, Ackerman Academy of Dermatopathology, New York

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

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Eumycetoma of the leg with tumefaction, deformity, and multiple sinus tracts in a patient from Costa Rica. Courtesy of Mervyn L. Elgart, MD, Washington, DC.
Eumycetoma of the foot with tumefaction, deformity, and multiple sinus tracts. Courtesy of Mervyn L. Elgart, MD, Washington, DC.
 
 
 
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