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Dermatologic Manifestations of Sporotrichosis Treatment & Management

  • Author: Scott D Miller, MD; Chief Editor: Dirk M Elston, MD  more...
 
Updated: May 17, 2016
 

Medical Care

Systemic antifungal agents are the mainstay of treatment. Antifungal agents are used for fungicidal or fungistatic eradication of the infective organism S schenkii.[23, 24]  An increase in cutaneous induration, redness, and local lymphadenopathy may be expected after treatment is started, resulting from an increased immune response to the antigenic challenge of the killed fungus. Thermal adjuvant therapy to systemic antifungals may be beneficial, as S schenckii does not survive above 39°C.[23, 24] Passive immunization with monoclonal antibody against a 70-kd putative adhesin of S schenckii induces protection in murine sporotrichosis, giving promise for future therapies for this and similar deep-space fungal infections.[17]

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Surgical Care

Surgery combined with antifungals for localized pulmonary disease has proven beneficial.[24]

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Consultations

Consultations may include an infectious disease specialist and/or an internist and subspecialists as indicated by organ system involvement.

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Contributor Information and Disclosures
Author

Scott D Miller, MD Dermatologist and Dermatologic Surgeon, High Plains Dermatology Center

Scott D Miller, MD is a member of the following medical societies: American Academy of Dermatology, American Society for Dermatologic Surgery

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Lester F Libow, MD Dermatopathologist, South Texas Dermatopathology Laboratory

Lester F Libow, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, Texas Medical Association

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Kathryn Schwarzenberger, MD Associate Professor of Medicine, Division of Dermatology, University of Vermont College of Medicine; Consulting Staff, Division of Dermatology, Fletcher Allen Health Care

Kathryn Schwarzenberger, MD is a member of the following medical societies: Women's Dermatologic Society, American Contact Dermatitis Society, Medical Dermatology Society, Dermatology Foundation, Alpha Omega Alpha, American Academy of Dermatology

Disclosure: Nothing to disclose.

References
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  16. Ruiz-Baca E, Toriello C, Perez-Torres A, Sabanero-Lopez M, Villagomez-Castro JC, Lopez-Romero E. Isolation and some properties of a glycoprotein of 70 kDa (Gp70) from the cell wall of Sporothrix schenckii involved in fungal adherence to dermal extracellular matrix. Med Mycol. July 2008. 4:1-13. [Medline].

  17. Nascimento RC, Espindola NM, Castro RA, et al. Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis. Eur J Immunol. 2008 Nov. 38(11):3080-9. [Medline].

  18. Rubio G, Sánchez G, Porras L, Alvarado Z. [Sporotrichosis: prevalence, clinical and epidemiological features in a reference center in Colombia]. Rev Iberoam Micol. 2010 Jun 30. 27(2):75-9. [Medline].

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  25. Infectious Diseases Society of America. Infections by Organism. Available at http://www.idsociety.org/organism/. Accessed: October 9, 2014.

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Close-up of an ulcerated nodule reveals the satellite lesions characteristic of lymphangitic (sporotrichoid) spread.
 
 
 
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