Lobomycosis Differential Diagnoses

  • Author: Kyle L Horner; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jan 26, 2012
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Kyle L Horner  MD, MS, Staff Physician, Silver Falls Dermatology, Corvallis, OR

Kyle L Horner is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Surgery, and American Medical Association

Disclosure: Nothing to disclose.

Coauthor(s)

Gregory J Raugi, MD, PhD  Professor, Department of Internal Medicine, Division of Dermatology, University of Washington at Seattle School of Medicine; Chief, Dermatology Section, Primary and Specialty Care Service, Veterans Administration Medical Center of Seattle

Gregory J Raugi, MD, PhD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

David P Fivenson, MD  Associate Director, St Joseph Mercy Hospital Dermatology Program, Ann Arbor, Michigan

David P Fivenson, MD is a member of the following medical societies: American Academy of Dermatology, Medical Dermatology Society, Michigan Dermatological Society, Michigan State Medical Society, Photomedicine Society, Society for Investigative Dermatology, and Wound Healing Society

Disclosure: Nothing to disclose.

David F Butler, MD  Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Jeffrey P Callen, MD  Professor of Medicine (Dermatology), Chief, Division of Dermatology, University of Louisville School of Medicine

Jeffrey P Callen, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and American College of Rheumatology

Disclosure: Amgen Honoraria Consulting; Celgene Honoraria Safety Monitoring Committee

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD  Director, Ackerman Academy of Dermatopathology, New York

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous author, Dr. Kord Honda, MD, to the development and writing of this article.

References

  1. Lobo J. Um caso de blastomicose produzido por uma especie nova encontrada em Recife. Rev Med Pernambucana. 1931;1:763-75.

  2. Fialho A. Blastomicose du tipo "Jorge Lobo". O Hospital. 1938;14:903.

  3. Borelli D. Aspergillus, sorpresas en micopatologia. Dermatol Venez. 1958;1:286.

  4. Vilela R, Mendoza L, Rosa PS, Belone AF, Madeira S, Opromolla DV, et al. Molecular model for studying the uncultivated fungal pathogen Lacazia loboi. J Clin Microbiol. Aug 2005;43(8):3657-61. [Medline].

  5. Ciferri R, Azevedo PC, Campos S. Taxonomy of Jorge Lobo's disease fungus. Inst Micol Univ Recife. 1956;53:1-21.

  6. Lacaz CS, Baruzzi RG, Rosa MCB. Doenca de Jorge Lobo. San Paulo: Editora da USP-IPSIS Grafica e Editora. 1986.

  7. Taborda PR, Taborda VA, McGinnis MR. Lacazia loboi gen. nov., comb. nov., the etiologic agent of lobomycosis. J Clin Microbiol. Jun 1999;37(6):2031-3. [Medline].

  8. Herr RA, Tarcha EJ, Taborda PR, Taylor JW, Ajello L, Mendoza L. Phylogenetic analysis of Lacazia loboi places this previously uncharacterized pathogen within the dimorphic Onygenales. J Clin Microbiol. Jan 2001;39(1):309-14. [Medline].

  9. Mendoza L, Ajello L, Taylor JW. The taxonomic status of Lacazia loboi and Rhinosporidium seeberi has been finally resolved with the use of molecular tools. Rev Iberoam Micol. Sep 2001;18(3):95-8. [Medline].

  10. Mendoza L, Vilela R, Rosa PS, Fernandes Belone AF. Lacazia loboi and Rhinosporidium seeberi: a genomic perspective. Rev Iberoam Micol. Dec 2005;22(4):213-6. [Medline].

  11. Sampaio MM, Braga-dias L. The armadillo Euphractus sexcinctus as a suitable animal for experimental studies of Jorge Lobo's disease. Rev Inst Med Trop Sao Paulo. Jul-Aug 1977;19(4):215-20. [Medline].

  12. Wiersema JP, Niemel PL. Lobo's disease in Surinam patients. Trop Geogr Med. Jun 1965;17(2):89-111. [Medline].

  13. Opromolla DV, Nogueira ME. Inoculation of Lacazia loboi into the subcutaneous tissue of the hamster cheek pouch. Rev Inst Med Trop Sao Paulo. May-Jun 2000;42(3):119-23. [Medline].

  14. Sampaio MM, Braga Dias L, Scaff L. Bizarre forms of the aetiologic agent in experimental Jorge Lobo's disease in tortoises. Rev Inst Med Trop Sao Paulo. May-Jun 1971;13(3):191-3. [Medline].

  15. Madeira S, Opromolla DV, Belone A. Inoculation of BALB/c mice with Lacazia loboi. Rev Inst Med Trop Sao Paulo. Sep-Oct 2000;42(5):239-43. [Medline].

  16. Belone AF, Madeira S, Rosa PS, Opromolla DV. Experimental reproduction of the Jorge Lobo's disease in BAlb/c mice inoculated with Lacazia loboi obtained from a previously infected mouse. Mycopathologia. 2002;155(4):191-4. [Medline].

  17. Madeira S, Fernandes Belone Ade F, Padovani CR, Araujo Omoprolla DV. Comparative experimental infection of Lacazia loboi in BALB/c and B10.A mice. Rev Iberoam Micol. Jun 2003;20(2):55-9. [Medline].

  18. Bhawan J, Bain RW, Purtilo DT, et al. Lobomycosis. An electronmicroscopic, histochemical and immunologic study. J Cutan Pathol. 1976;3(1):5-16. [Medline].

  19. Sesso A, Baruzzi RG. Interaction between macrophage and parasite cells in lobomycosis. The thickened cell wall of Paracoccidioides loboi exhibits apertures to the extracellular milieu. J Submicrosc Cytol Pathol. Jul 1988;20(3):537-48. [Medline].

  20. Woodard JC. Electron microscopic study of lobomycosis (Loboa loboi). Lab Invest. Dec 1972;27(6):606-12. [Medline].

  21. Landman G, Velludo MA, Lopes JA, Mendes E. Crossed-antigenicity between the etiologic agents of lobomycosis and paraccocidioidomycosis evidenced by an immunoenzymatic method (PAP). Allergol Immunopathol (Madr). Jul-Aug 1988;16(4):215-8. [Medline].

  22. Camargo ZP, Baruzzi RG, Maeda SM, Floriano MC. Antigenic relationship between Loboa loboi and Paracoccidioides brasiliensis as shown by serological methods. Med Mycol. Dec 1998;36(6):413-7. [Medline].

  23. Haubold EM, Aronson JF, Cowan DF, McGinnis MR, Cooper CR Jr. Isolation of fungal rDNA from bottlenose dolphin skin infected with Loboa loboi. Med Mycol. Oct 1998;36(5):263-7. [Medline].

  24. Burns RA, Roy JS, Woods C, Padhye AA, Warnock DW. Report of the first human case of lobomycosis in the United States. J Clin Microbiol. Mar 2000;38(3):1283-5. [Medline].

  25. Vilani-Moreno FR, Lauris JR, Opromolla DV. Cytokine quantification in the supernatant of mononuclear cell cultures and in blood serum from patients with Jorge Lobo's disease. Mycopathologia. Jul 2004;158(1):17-24. [Medline].

  26. Marcos EV, Souza FC, Torres EA, Lauris JR, Opromolla DV. [Study of the association between human leukocyte antigens and Jorge Lobo's disease]. Rev Soc Bras Med Trop. Sep-Oct 2005;38(5):399-401. [Medline].

  27. De Vries GA, Laarman JJ. A case of Lobo's disease in the dolphin Sotalia Guianensis. Aquatic Mammels. 1973;1:26-33.

  28. Paniz-Mondolfi AE, Sander-Hoffmann L. Lobomycosis in inshore and estuarine dolphins. Emerg Infect Dis. Apr 2009;15(4):672-3. [Medline].

  29. Caldwell DK, Caldwell MC, Woodard JC, Ajello L, Kaplan W, McClure HM. Lobomycosis as a disease of the Atlantic bottle-nosed dolphin (Tursiops truncatus Montagu, 1821). Am J Trop Med Hyg. Jan 1975;24(1):105-14. [Medline].

  30. Symmers WS. A possible case of Lobo's disease acquired in Europe from a bottle-nosed dolphin (Tursiops truncatus). Bull Soc Pathol Exot Filiales. Dec 1983;76(5 Pt 2):777-84. [Medline].

  31. Reif JS, Mazzoil MS, McCulloch SD, et al. Lobomycosis in Atlantic bottlenose dolphins from the Indian River Lagoon, Florida. J Am Vet Med Assoc. Jan 1 2006;228(1):104-8. [Medline].

  32. Norton SA. Dolphin-to-human transmission of lobomycosis?. J Am Acad Dermatol. Oct 2006;55(4):723-4. [Medline].

  33. Rotstein DS, Burdett LG, McLellan W, et al. Lobomycosis in offshore bottlenose dolphins (Tursiops truncatus), North Carolina. Emerg Infect Dis. Apr 2009;15(4):588-90. [Medline].

  34. Burdett Hart L, Rotstein DS, Wells RS, Bassos-Hull K, Schwacke LH. Lacaziosis and lacaziosis-like prevalence among wild, common bottlenose dolphins Tursiops truncatus from the west coast of Florida, USA. Dis Aquat Organ. May 24 2011;95(1):49-56. [Medline].

  35. Haubold EM, Cooper CR Jr, Wen JW, McGinnis MR, Cowan DF. Comparative morphology of Lacazia loboi (syn. Loboa loboi) in dolphins and humans. Med Mycol. Feb 2000;38(1):9-14. [Medline].

  36. Brun AM. Lobomycosis in three Venezuelan patients. Int J Dermatol. Apr 1999;38(4):302-5. [Medline].

  37. Borelli D. Lobomycosis experimental. Dermatol Venez. 1962;3:72-82.

  38. Rosa PS, Soares CT, Belone Ade F, et al. Accidental Jorge Lobo's disease in a worker dealing with Lacazia loboi infected mice: a case report. J Med Case Reports. Feb 16 2009;3:67. [Medline].

  39. Miranda MF, Silva AJ. Vinyl adhesive tape also effective for direct microscopy diagnosis of chromomycosis, lobomycosis, and paracoccidioidomycosis. Diagn Microbiol Infect Dis. May 2005;52(1):39-43. [Medline].

  40. Azulay RD, Carneiro JA, Da Graca M, Cunha S, Reis LT. Keloidal blastomycosis (Lobo's disease) with lymphatic involvement: a case report. Int J Dermatol. Jan-Feb 1976;15(1):40-2. [Medline].

  41. Talhari C, Rabelo R, Nogueira L, Santos M, Chrusciak-Talhari A, Talhari S. Lobomycosis. An Bras Dermatol. Apr 2010;85(2):239-40. [Medline].

  42. Baruzzi RG, Castro RM, D'Andretta C Jr, Carvalhal S, Ramos OL, Pontes PL. Occurrence of Lobo's blastomycosis among "Caiabi," Brazilian Indians. Int J Dermatol. Mar-Apr 1973;12(2):95-9. [Medline].

  43. Rodríguez-Toro G, Tellez N. Lobomycosis in Colombian Amer Indian patients. Mycopathologia. Oct 1992;120(1):5-9. [Medline].

  44. Elsayed S, Kuhn SM, Barber D, Church DL, Adams S, Kasper R. Human case of lobomycosis. Emerg Infect Dis. Apr 2004;10(4):715-8. [Medline].

  45. Al-Daraji WI. Cutaneous lobomycosis: a delayed diagnosis. Am J Dermatopathol. Dec 2008;30(6):575-7. [Medline].

  46. Baruzzi RG, Rodrigues DA, Michalany NS, Salomao R. Squamous-cell carcinoma and lobomycosis (Jorge Lobo's disease). Int J Dermatol. Apr 1989;28(3):183-5. [Medline].

  47. Tapia A, Torres-Calcindo A, Arosemena R. Keloidal blastomycosis (Lobo's disease) in Panama. Int J Dermatol. Sep 1978;17(7):572-4. [Medline].

  48. Rose P, Hay RJ. Lobomycosis (Lobo's disease): report of a case from Guyana. Am J Trop Med Hyg. Jul 1981;30(4):903-4. [Medline].

  49. Pradinaud R. [Between Yucatan, Florida and French Guiana does lobomycosis exist in the Antilles?]. Bull Soc Pathol Exot Filiales. May-Jun 1984;77(3):392-400. [Medline].

  50. Romero RO. Enfermedad de Jorge Lobo (blastomicosis queloidiana). Primer caso diagnosticado en el Puru. Arch Per Pat Clin. 1972;26:63-86.

  51. Zavala-Velasquez J, Perez AR. Enfermedad de Lobo (lobomicosis). Primer caso mexicano. Dermatologia (Mex). 1978;22:5-12.

  52. Baruzzi RG, Lacaz Cda S, de Souza FA. [Natural history of Jorge Lobo's disease. Occurrence among the Caiabi Indians (Central Brazil)]. Rev Inst Med Trop Sao Paulo. Nov-Dec 1979;21(6):303-38. [Medline].

  53. Fuchs J, Milbradt R, Pecher SA. Lobomycosis (keloidal blastomycosis): case reports and overview. Cutis. Sep 1990;46(3):227-34. [Medline].

  54. Machado P de A. Regrassao espontanea de lesoes maculosas na blastomicose de Jorge Lobo. Acta Amaz (Manaus). 1972;2:47-50.

  55. Rodríguez-Toro G. Lobomycosis. Int J Dermatol. May 1993;32(5):324-32. [Medline].

  56. Lawrence DN, Ajello L. Lobomycosis in western Brazil: report of a clinical trial with ketoconazole. Am J Trop Med Hyg. Jan 1986;35(1):162-6. [Medline].

  57. Opromolla DV, Belone AF, Taborda PR, Rosa PS. Lymph node involvement in Jorge Lobo's disease: report of two cases. Int J Dermatol. Dec 2003;42(12):938-41. [Medline].

  58. Pang KR, Wu JJ, Huang DB, Tyring SK. Subcutaneous fungal infections. Dermatol Ther. 2004;17(6):523-31. [Medline].

  59. Baruzzi RG, Marcopito LF, Vicente LS, Michalany NS. Jorge Lobo's disease (keloidal blastomycosis) and tinea imbricata in Indians from the Xingu National Park, Central Brazil. Trop Doct. Jan 1982;12(1):13-5. [Medline].

  60. Pecher SA, Fuchs J. Cellular immunity in lobomycosis (keloidal blastomycosis). Allergol Immunopathol (Madr). Nov-Dec 1988;16(6):413-5. [Medline].

  61. Vilani-Moreno FR, Belone AF, Soares CT, Opromolla DV. Immunohistochemical characterization of the cellular infiltrate in Jorge Lobo's disease. Rev Iberoam Micol. Mar 2005;22(1):44-9. [Medline].

  62. Xavier MB, Ferreira MM, Quaresma JA, de Brito A. HIV and lacaziosis, Brazil. Emerg Infect Dis. Mar 2006;12(3):526-7. [Medline].

  63. Talhari C, Chrusciak-Talhari A, de Souza JV, Araujo JR, Talhari S. Exfoliative cytology as a rapid diagnostic tool for lobomycosis. Mycoses. Mar 2009;52(2):187-9. [Medline].

  64. Vilani-Moreno FR, Belone Ade F, Rosa PS, Madeira S, Opromolla DV. Evaluation of the vital staining method for Lacazia loboi through the experimental inoculation of BALB/c mice. Med Mycol. Jun 2003;41(3):211-6. [Medline].

  65. Quaresma JA, Unger D, Pagliari C, Sotto MN, Duarte MI, de Brito AC. Immunohistochemical study of Langerhans cells in cutaneous lesions of the Jorge Lobo's disease. Acta Trop. Apr 2010;114(1):59-62. [Medline].

  66. Jaramillo D, Cortes A, Restrepo A, Builes M, Robledo M. Lobomycosis. Report of the eighth Colombian case and review of the literature. J Cutan Pathol. 1976;3(4):180-9. [Medline].

  67. Rodríguez G, Sarmiento L. The asteroid bodies of sporotrichosis. Am J Dermatopathol. Jun 1998;20(3):246-9. [Medline].

  68. Rodriguez G, Barrera GP. The asteroid body of lobomycosis. Mycopathologia. 1996-1997;136(2):71-4. [Medline].

  69. Fischer M, Chrusciak Talhari A, Reinel D, Talhari S. [Sucessful treatment with clofazimine and itraconazole in a 46 year old patient after 32 years duration of disease]. Hautarzt. Oct 2002;53(10):677-81. [Medline].

  70. Silva D. Treatment of Lobo's disease with clofazimine (B 663) [in French]. Bull Soc Pathol Exot Filiales. Nov-Dec 1978;71(6):409-12. [Medline].

  71. Baruzzi RG, Marcopito LF, Michalany NS, Livianu J, Pinto NR. Early diagnosis and prompt treatment by surgery in Jorge Lobo's disease (keloidal blastomycosis). Mycopathologia. Apr 10 1981;74(1):51-4. [Medline].

 
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Keloidal nodule on the leg. Courtesy of Dr Roberto Baruzzi, Sao Paulo, Brazil.
Lobomycosis in this patient appears as a flat plaque lesion. Courtesy of Dr Roberto Baruzzi, Sao Paulo, Brazil.
Separate keloidal lesions in a localized area. Courtesy of Dr Roberto Baruzzi, Sao Paulo, Brazil.
Characteristic histologic appearance of the organism. Courtesy of Dr Roberto Baruzzi, Sao Paulo, Brazil.
 
 
 
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