Lobomycosis (lacaziosis) is a self-limited, chronic fungal infection of the skin endemic in rural regions in South America and Central America. Natives of the Brazilian rain forest call this disease miraip or piraip, meaning "that which burns."
Jorge Lobo first described this infection in the medical literature  as keloidal blastomycosis in a patient from the Amazon Valley of Brazil. Since the original report, lobomycosis has been reported in many South American countries, in North American travelers to endemic regions, closely related disease in two species of Atlantic dolphins, and in one marine park dolphin trainer. 
Three species names have been recommended: Loboa loboi  ; Paracoccidioides loboi  because of its antigenic relationship to Paracoccidioides brasiliensis; and Lacazia loboi  in deference to Lacaz, who contributed much to the knowledge of the disease. Other names that have been used are Glenosporella loboi and Blastomyces loboi. Based on recent molecular studies, the name Lacazia loboi is the current recommended name.  As is common in medical mycology, the name of the disease is taken from the genus of the etiologic agent, and therefore, lacaziosis has been proposed for the disease name rather than lobomycosis. 
The organism responsible for lobomycosis has yet to be cultured in vitro. The infection has been transmitted to an armadillo,  to the footpads and cheek pouches of golden hamsters, [13, 14] and to tortoises.  Live organisms have been maintained for 18 months in the footpads of BALB/c mice. [16, 17, 18] However, most of our knowledge of the etiologic agent of lobomycosis is derived from histopathologic, electron microscopic, and molecular studies. 
The fungus is abundant in lobomycotic skin lesions. It is a spherical intracellular yeast 6-12 μm diameter.  The fungus is remarkably homogeneous, with an average diameter of 9 μm. Although debate exists as to whether nuclei and organelles of fungal origin have been definitively identified, [19, 20, 21] 2 lines of evidence support the fungal nature of the etiologic agent of lobomycosis. First, immunologic studies show cross-reactivity of the antiserum obtained from patients affected by lobomycosis with several antigens prepared from cultures of P brasiliensis [22, 23] Second, sequence analysis of ribosomal RNA (rRNA) obtained from skin lesions in dolphins are highly homologous to rRNA sequences from the genus Cladosporium  and from P brasiliensis.  Emerging data suggest that cetacean lacaziosis-like disease is related to L loboi, but more closely related to P brasiliensis and P lutzii. [2, 25]
L loboi is predominantly an intracellular pathogen. Organisms, singly or in chains, reside predominantly in macrophage vacuoles. They probably reproduce by budding; linear or radiating chains of as many as 20 organisms linked by tubules have been observed.  The melanin-containing birefringent 1-μm-thick cell wall  resists digestion by macrophages and may be central in contributing to the chronicity of the infection. 
The cytokines secreted in vitro by mononuclear cells of patients with lobomycosis showed increased interleukin-4 and interleukin-6 and decreased interleukin-2 production compared with mononuclear cells from normal patients. Mononuclear cells from patients with generalized disease produce higher levels of interferon-gamma than those from patients with localized disease. Taken together, these results suggest that mononuclear cells from patients with lacaziosis are predominantly of the Th2 profile. Further studies are needed to assess the significance of these observations.  When compared to healthy control subjects of the same ethnic group no human leukocyte antigen (HLA) susceptibility or resistance could be demonstrated in 21 patients with lobomycosis.  However, HLA-DR7 was found to be potentially protective.
The natural reservoir of L loboi is unknown. Its likely habitat is somewhere in the rural environment because of the observed distribution of the disease. Soil and vegetation seem to be likely sources of infection.
L loboi has also been recovered from lobomycotic lesions of the Guiana dolphin Sotalia guianensis from the Surinam River estuary [29, 30] and Tursiops truncatus dolphins in Florida, Hawaii, North Carolina, and the Bay of Biscay in Europe [31, 32, 33, 34, 30, 35] ; these findings imply that some aquatic reservoir also exists.
Lobomycosis is similarly manifested in humans and in dolphins; the skin lesions and morphologic features of the organism are nearly identical, and at least one case of dolphin-to-human transmission has been documented.  However, the organism in dolphins is somewhat smaller than that seen in humans, and it may not prove to be identical.  In fact, a recent article suggests that transmission of any kind from dolphins to humans occurs rarely, if at all. 
Lobomycosis often develops at sites of minor trauma, but sometimes, no history of trauma can be recalled.  The disease has been associated with ear lesions in persons who carry natural materials on their shoulder, with snake and insect bites,  and in one case, with trauma associated with exposure to high-pressure falling water.  Human-to-human transmission has not been documented, though the inoculation of a tissue homogenate reproduced the disease,  and 1 case in Europe may have been caused by occupational exposure to an infected dolphin  . Murine-to-human transmission has been postulated but not proven. 
Once phagocytized, the organisms initiate a slow replication process, which may account for the slow incubation period and slow development of lesions. Transforming growth factor-β affects mononuclear function, inhibiting expression of interferon-gamma and nitric oxide.  In addition, interleukin (IL)–10 has been found to be importantly present in the dermis of affected individuals. Transforming growth factor-β and IL-10 inhibit the cellular immune response, thus altering the function of macrophages. 
Mechanisms for dissemination are unclear; however, newer lesions presenting adjacent to affected areas supports dissemination by contiguity or autoinoculation.  Although L loboi is generally considered a deep-seated mycosis, it has shown the potential for transepidermal elimination of infectious organisms. 
Dissemination within an individual also may occur by means of lymphatic spread.  Hematogenous dissemination has been proposed as a possibility, owing to a description of a patient presenting with testicular metastasis. 
Only one case of lobomycosis has been reported in the United States. The patient was exposed to a waterfall in Venezuela years before presentation. 
Approximately 64% of all known cases have occurred in Brazil [27, 45] and though lobomycosis is uncommon, it occurs in as many as 8.5% of the members of some tribes indigenous to South America, for example, the Amoruas tribe of the Casanare state in Colombia and the Caiabi Indians of Brazil. [46, 47] The first report  of imported human lobomycosis in Canada was published in 2004 and in South Africa in 2008. 
Other than a few tribes in South America (eg, the Amoruas, the Caiabi), no racial prevalence is known. One case has been reported in the United States, but the patient was exposed to a waterfall in Venezuela years before his or her presentation.  The case in Europe was reported in a handler of an affected dolphin. 
The disease has been reported in many areas: Costa Rica,  Panama,  Venezuela,  Colombia,  Guyana,  Surinam,  French Guyana,  Ecuador,  Peru,  Bolivia,  Honduras,  Mexico,  Holland,  the United States,  and Canada. 
The disease is usually found in areas higher than 200 m with tropical, humid, or subtropical forests; an average temperature of 24°C; and more than 2000 mm of annual rainfall. 
Lobomycosis is more common in men (68-92% of cases) than in women.  The disease is most common in farmers, rubber workers, hunters, and prospectors.  The high prevalence among women of some tribes is attributed to their active participation in farming activities.
The age of onset is 1-70 years, with an average patient age of 38 years. 
Lobomycosis does not affect the general health of the patient. Current treatment is disappointing, and most patients continue to have lobomycosis unless it is surgically treated at an early stage. No deaths from lobomycosis have been reported. One patient in whom squamous cell carcinoma developed in a lobomycotic nodule later died from lung metastases. 
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