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Cutaneous Cryptococcus Treatment & Management

  • Author: David G Moskowitz, MD; Chief Editor: Dirk M Elston, MD  more...
 
Updated: Feb 16, 2016
 

Medical Care

In immunocompetent patients, disseminated, non-CNS Cryptococcus infection can be treated with oral fluconazole for 3-6 months or with itraconazole for 6-12 months. CNS involvement is treated with intravenous amphotericin B combined with flucytosine, followed by oral fluconazole. In immunosuppressed patients, the initial treatments are similar, but lifelong maintenance treatment with fluconazole may be required. Primary cutaneous disease can be treated with oral fluconazole or itraconazole.

Also see the following related clinical guidelines:

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Surgical Care

Surgical excision or cryotherapy may play a role in primary cutaneous infections.

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Consultations

Consultation with an infectious disease specialist should be obtained for all patients to evaluate for disseminated disease. As warranted, consultations should be obtained from a pulmonologist or neurologist, among others, depending on the extent of disease involvement.

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Contributor Information and Disclosures
Author

David G Moskowitz, MD Associate Physician, Department of Dermatology, Kaiser Permanente in Oakland, California

David G Moskowitz, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology

Disclosure: Nothing to disclose.

Coauthor(s)

Noah S Scheinfeld, JD, MD, FAAD Assistant Clinical Professor, Department of Dermatology, Weil Cornell Medical College; Consulting Staff, Department of Dermatology, St Luke's Roosevelt Hospital Center, Beth Israel Medical Center, New York Eye and Ear Infirmary; Assistant Attending Dermatologist, New York Presbyterian Hospital; Assistant Attending Dermatologist, Lenox Hill Hospital, North Shore-LIJ Health System; Private Practice

Noah S Scheinfeld, JD, MD, FAAD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Serve(d) as a speaker or a member of a speakers bureau for: Abbvie<br/>Received income in an amount equal to or greater than $250 from: Optigenex<br/>Received salary from Optigenex for employment.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Camila K Janniger, MD Clinical Professor of Dermatology, Clinical Associate Professor of Pediatrics, Chief of Pediatric Dermatology, Rutgers New Jersey Medical School

Camila K Janniger, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

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Umbilicated papule of cutaneous Cryptococcus infection on the face of a male.
 
 
 
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