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Cowden Disease (Multiple Hamartoma Syndrome) Differential Diagnoses

  • Author: Katherine H Fiala, MD; Chief Editor: William D James, MD  more...
 
Updated: Feb 07, 2014
 
 

Diagnostic Considerations

Central facial lesions

Multiple trichilemmomas

Multiple trichoepitheliomas

Adenoma sebaceum (multiple angiofibromas)

Darier disease

Syringomas (usually located under eyes as opposed to perinasally)

Fibrofolliculomas (in Birt-Hogg-Dube syndrome)

Oral papillomas

Multiple benign fibromas

Multiple neuromas (Sipple syndrome, multiple endocrine neoplasia 2b, or multiple endocrine neoplasia 3)

Tuberous sclerosis

Darier disease

Heck disease

Lipoid proteinosis

Goltz syndrome

Florid oral papillomatosis

Palmoplantar keratosis

Arsenic keratoses

Keratosis palmaris et plantaris punctata

Darier disease

Differential Diagnoses

 
 
Contributor Information and Disclosures
Author

Katherine H Fiala, MD Assistant Professor, Department of Dermatology, Scott and White Northside Clinic

Katherine H Fiala, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Christian Medical and Dental Associations

Disclosure: Nothing to disclose.

Coauthor(s)

Christopher Grant Staples, MD Chief Resident, Department of Dermatology, Texas A&M University Health Science Center, Scott & White

Christopher Grant Staples, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association, Society for Pediatric Dermatology, Texas Dermatological Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Lester F Libow, MD Dermatopathologist, South Texas Dermatopathology Laboratory

Lester F Libow, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, Texas Medical Association

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Craig A Elmets, MD Professor and Chair, Department of Dermatology, Director, Chemoprevention Program Director, Comprehensive Cancer Center, UAB Skin Diseases Research Center, University of Alabama at Birmingham School of Medicine

Craig A Elmets, MD is a member of the following medical societies: American Academy of Dermatology, American Association of Immunologists, American College of Physicians, American Federation for Medical Research, Society for Investigative Dermatology

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: University of Alabama at Birmingham; University of Alabama Health Services Foundation<br/>Serve(d) as a speaker or a member of a speakers bureau for: Ferndale Laboratories<br/>Received research grant from: NIH, Veterans Administration, California Grape Assn<br/>Received consulting fee from Astellas for review panel membership; Received salary from Massachusetts Medical Society for employment; Received salary from UpToDate for employment. for: Astellas.

Acknowledgements

Christopher Grant Staples, MD Resident Physician, Scott and White Dermatology

Disclosure: Nothing to disclose.

Charles Miller, MD Chief, Department of Dermatology, Kaiser Permanente

Charles Miller is a member of the following medical societies: American Academy of Dermatology.

Disclosure: Nothing to disclose.

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A patient with trichilemmoma papules on the face.
Multiple benign oral fibromas.
Multiple trichilemmomas in patient with Cowden disease.
 
 
 
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