eMedicine Specialties > Dermatology > Internal Medicine
Multiple Endocrine Neoplasia Type 1: Treatment & Medication
Updated: Oct 16, 2008
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
- Multimedia
Treatment
Surgical Care
- Patients may desire to have these cutaneous tumors removed because of cosmetic concerns, particularly with the larger facial angiofibromas. A variety of methods have been used to treat angiofibromas in patients with tuberous sclerosis, and these methods are likely applicable to angiofibromas in patients with multiple endocrine neoplasia type 1 (MEN1). These methods include shave excision, dermabrasion, and carbon dioxide laser.16 Cosmetic improvement of facial angiofibromas in patients with MEN1 has been obtained with shave excision. In some cases, lesions treated in this way have slowly reappeared.
- Collagenomas and lipomas can be excised, and lipomas can also be treated by liposuction.
- The Medscape Dermatologic Surgery Resource Center may be of interest.
Consultations
More on Multiple Endocrine Neoplasia Type 1 |
| Overview: Multiple Endocrine Neoplasia Type 1 |
| Differential Diagnoses & Workup: Multiple Endocrine Neoplasia Type 1 |
Treatment & Medication: Multiple Endocrine Neoplasia Type 1 |
| Follow-up: Multiple Endocrine Neoplasia Type 1 |
| Multimedia: Multiple Endocrine Neoplasia Type 1 |
| References |
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References
Brandi ML, Gagel RF, Angeli A, Bilezikian JP, Beck-Peccoz P, Bordi C, et al. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab. Dec 2001;86(12):5658-71. [Medline].
Asgharian B, Turner ML, Gibril F, Entsuah LK, Serrano J, Jensen RT. Cutaneous tumors in patients with multiple endocrine neoplasm type 1 (MEN1) and gastrinomas: prospective study of frequency and development of criteria with high sensitivity and specificity for MEN1. J Clin Endocrinol Metab. Nov 2004;89(11):5328-36. [Medline].
Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, et al. Menin molecular interactions: insights into normal functions and tumorigenesis. Horm Metab Res. Jun 2005;37(6):369-74. [Medline].
Lemos MC, Thakker RV. Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene. Hum Mutat. Jan 2008;29(1):22-32. [Medline].
Pack S, Turner ML, Zhuang Z, Vortmeyer AO, Böni R, Skarulis M, et al. Cutaneous tumors in patients with multiple endocrine neoplasia type 1 show allelic deletion of the MEN1 gene. J Invest Dermatol. Apr 1998;110(4):438-40. [Medline].
Vortmeyer AO, Böni R, Pack SD, Darling TN, Zhuang Z. Perivascular cells harboring multiple endocrine neoplasia type 1 alterations are neoplastic cells in angiofibromas. Cancer Res. Jan 15 1999;59(2):274-8. [Medline].
Marx SJ. Molecular genetics of multiple endocrine neoplasia types 1 and 2. Nat Rev Cancer. May 2005;5(5):367-75. [Medline].
Darling TN, Skarulis MC, Steinberg SM, Marx SJ, Spiegel AM, Turner M. Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. Arch Dermatol. Jul 1997;133(7):853-7. [Medline].
Hoang-Xuan T, Steger JW. Adult-onset angiofibroma and multiple endocrine neoplasia type I. J Am Acad Dermatol. Nov 1999;41(5 Pt 2):890-2. [Medline].
Sakurai A, Hashizume K, Fukushima Y. Facial angiofibroma as an initial manifestation in multiple endocrine neoplasia type 1. Intern Med. 2008;47(11):1067-8. [Medline].
Vidal A, Iglesias MJ, Fernández B, Fonseca E, Cordido F. Cutaneous lesions associated to multiple endocrine neoplasia syndrome type 1. J Eur Acad Dermatol Venereol. Jul 2008;22(7):835-8. [Medline].
Sakurai A, Matsumoto K, Ikeo Y, Nishio SI, Kakizawa T, Arakura F, et al. Frequency of facial angiofibromas in Japanese patients with multiple endocrine neoplasia type 1. Endocr J. Oct 2000;47(5):569-73. [Medline].
Roach ES, Sparagana SP. Diagnosis of tuberous sclerosis complex. J Child Neurol. Sep 2004;19(9):643-9. [Medline].
Fuleihan Gel-H, Rubeiz N. Dermatologic manifestations of parathyroid-related disorders. Clin Dermatol. Jul-Aug 2006;24(4):281-8. [Medline].
Xia Y, Darling TN. Rapidly growing collagenomas in multiple endocrine neoplasia type I. J Am Acad Dermatol. May 2007;56(5):877-80. [Medline].
Bittencourt RC, Huilgol SC, Seed PT, Calonje E, Markey AC, Barlow RJ. Treatment of angiofibromas with a scanning carbon dioxide laser: a clinicopathologic study with long-term follow-up. J Am Acad Dermatol. Nov 2001;45(5):731-5. [Medline].
Further Reading
Keywords
multiple endocrine neoplasia type 1, MEN-1, Wermer syndrome, multiple endocrine adenomatosis, MEN1, endocrine tumors, cutaneous tumors, angiofibromas, collagenomas, lipomas
Treatment & Medication: Multiple Endocrine Neoplasia Type 1