Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

Dermatologic Manifestations of Pellagra Medication

  • Author: Vladimir Hegyi, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
 
Updated: Feb 22, 2016
 

Medication Summary

The goals of pharmacotherapy are to correct vitamin deficiency, prevent complications, and reduce morbidity.

Next

Vitamins

Class Summary

Exogenous administration cures the syndrome and, within the levels prescribed, niacin use is not associated with the uncomfortable flushing observed in other conditions (eg, hypercholesterolemia). Niacinamide (nicotinamide) is usually tolerated better than nicotinic acid, and it is the preferred agent because it does not precipitate the flushing, itching, and burning observed after the ingestion of large doses of niacin.

Niacin (Vitamin B-3)

 

Niacin is used in tissue respiration, lipid metabolism, and glycogenolysis.

Previous
 
 
Contributor Information and Disclosures
Author

Vladimir Hegyi, MD, PhD Professor, Institute of Clinical and Experimental Dermatovenereology, Slovak Republic

Vladimir Hegyi, MD, PhD is a member of the following medical societies: European Academy of Dermatology and Venereology, Slovakian Dermatovenerological Society, European Dermatology Forum

Disclosure: Nothing to disclose.

Coauthor(s)

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public Affairs and Administration

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, New York Academy of Medicine, American Academy of Dermatology, American College of Physicians, Sigma Xi

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Jeffrey J Miller, MD Associate Professor of Dermatology, Pennsylvania State University College of Medicine; Staff Dermatologist, Pennsylvania State Milton S Hershey Medical Center

Jeffrey J Miller, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Society for Investigative Dermatology, Association of Professors of Dermatology, North American Hair Research Society

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

References
  1. Hegyi J, Schwartz RA, Hegyi V. Pellagra: dermatitis, dementia, and diarrhea. Int J Dermatol. 2004 Jan. 43(1):1-5. [Medline].

  2. Rajakumar K. Pellagra in the United States: a historical perspective. South Med J. 2000 Mar. 93(3):272-7. [Medline].

  3. Rille JH. Medizinische Gesellchaft Leipzig. Sitzug vom 16. November 1926. Ueber Pellegra (mit Lichtbildern). Dermatol Wochenschrift. 1927. 6:189.

  4. Elvehjem CA, Madden RJ, Strong FM, Woolley DW. Relation of nicotinic acid and nicotinic acid amide to canine black tongue. J Am Chem Soc. 1937. 59:1767-68.

  5. Murray MF. Niacin as a potential AIDS preventive factor. Med Hypotheses. 1999 Nov. 53(5):375-9. [Medline].

  6. Murray MF, Langan M, MacGregor RR. Increased plasma tryptophan in HIV-infected patients treated with pharmacologic doses of nicotinamide. Nutrition. 2001 Jul-Aug. 17(7-8):654-6. [Medline].

  7. Pitche P, Kombate K, Tchangai-Walla K. [Prevalence of HIV infection in patients with pellagra and pellagra- like erythemas]. Med Trop (Mars). 1999. 59(4):365-7. [Medline].

  8. Bruno MC, Vilela MA, de Oliveira CA. Study on dermatoses and their prevalence in groups of confirmed alcoholic individuals in comparison to a non-alcoholic group of individuals. An Bras Dermatol. 2013 May-Jun. 88(3):368-75. [Full Text].

  9. Ladoyanni E, Cheung ST, North J, Tan CY. Pellagra occurring in a patient with atopic dermatitis and food allergy. J Eur Acad Dermatol Venereol. 2007 Mar. 21(3):394-6. [Medline].

  10. Kertesz SG. Pellagra in 2 homeless men. Mayo Clin Proc. 2001 Mar. 76(3):315-8. [Medline].

  11. Lorentzen HF, Fugleholm AM, Weismann K. [Zinc deficiency and pellagra in alcohol abuse]. Ugeskr Laeger. 2000 Dec 11. 162(50):6854-6. [Medline].

  12. Lu JY, Yu CL, Wu MZ. Pellagra in an immunocompetent patient with cytomegalovirus colitis. Am J Gastroenterol. 2001 Mar. 96(3):932-4. [Medline].

  13. Baquet S, Wuillaume F, Van Egmond K, Ibanez F. Pellagra outbreak in Kuito, Angola. Lancet. 2000 May 20. 355(9217):1829-30. [Medline].

  14. Stratigos JD, Katsambas A. Pellagra: a still existing disease. Br J Dermatol. 1977 Jan. 96(1):99-106. [Medline].

  15. Oztürk F, Koca R, Aydin M, Cantürk MT, Akpolat I, Küçüködük S. Pellagra: a sporadic pediatric case with a full triad of symptoms. Cutis. 2001 Jul. 68(1):31-4. [Medline].

  16. Isaac S. The "gauntlet" of pellagra. Int J Dermatol. 1998 Aug. 37(8):599. [Medline].

  17. Karthikeyan K, Thappa DM. Pellagra and skin. Int J Dermatol. 2002 Aug. 41(8):476-81. [Medline].

  18. Stratigos AJ, Antoniou C, Papathanakou E, Daboudi M, Tranaka K, Tsara K, et al. Spectrum of idiopathic photodermatoses in a Mediterranean country. Int J Dermatol. 2003 Jun. 42(6):449-54. [Medline].

  19. Brown TM. Pellagra: an old enemy of timeless importance. Psychosomatics. 2010. 51(2):93-97. [Full Text].

  20. Kapas I, Majtenyi K, Törö K, Keller E, Voigtländer T, Kovacs GG. Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. Metab Brain Dis. 2012 Jun. 27(2):231-5. [Medline].

  21. Shah GM, Shah RG, Veillette H, Kirkland JB, Pasieka JL, Warner RR. Biochemical assessment of niacin deficiency among carcinoid cancer patients. Am J Gastroenterol. 2005 Oct. 100(10):2307-14. [Medline].

  22. Nogueira A, Duarte AF, Magina S, Azevedo F. Pellagra associated with esophageal carcinoma and alcoholism. Dermatol Online J. 2009. 15(5):8. [Full Text].

  23. Reichman O, Sobel JD. Vulvovaginal pellagra and lichen sclerosus complicating carcinoid syndrome. Obstet Gynecol. 2009. 113(2 Pt 2):543-545. [Full Text].

  24. Kaimal S, Thappa DM. Diet in dermatology: revisited. Indian J Dermatol Venereol Leprol. 2010 Mar-Apr. 76(2):103-15. [Medline].

Previous
Next
 
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.