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Dermatologic Manifestations of Pellagra

  • Author: Vladimir Hegyi, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
 
Updated: Feb 22, 2016
 

Background

Pellagra is clinically manifested by the 4 D' s: photosensitive dermatitis, diarrhea, dementia, and death. The full tetrad of symptoms is usually not well developed in infants and children. This vitamin deficiency responds to treatment with nicotinic acid.[1]

Pellagra is observed in malnourished individuals and as a complication of isoniazid therapy; however, the diagnosis is often overlooked or delayed, occasionally with life-threatening consequences. Isoniazid-induced pellagra may occur despite pyridoxine supplementation.

Pellagra first was recognized in the United States in 1902, and it became an epidemic in the American South.[2] Poverty and corn consumption were the most frequently observed risk factors. The public became pellagraphobic, and patients were shunned and ostracized. Hungarian born Dr Joseph Goldberger of the United States Public Health Service eventually solved the problem. He was able to prevent and induce pellagra by using dietary modification.[1]

Pellagra is defined by the systemic disease resulting from niacin deficiency, and it is characterized by diarrhea, dermatitis, dementia, and death, which usually appear in this order. GI tract symptoms always precede dermatitis, or, according to Rille, "Pellagra begins in the stomach".[3]

Gasper Casal first described pellagra in 1762 in Oviedo, Asturias. Casal noted the malady among poor peasants of Asturias and termed it mal de la rose because all affected patients had the typical reddish and glossy rash on the dorsum of the hands and feet. Skin lesions on the neck are designated as the Casal necklace. Casal had observed that patients with pellagra were all poor, subsisted mainly on maize, and rarely ate fresh meat. Before Casal, the skin changes were termed Hiob disease; stigmata of Saint Francis of Assisi; or, in Italy, scorbuto alpino. François Thiery published the first description of pellagra in 1755. Francesco Frapolli called the disease vulgo pelagrain and first used the term pellagra in 1771.

In Italian vernacular, pellagra means "skin that is rough" and refers to the thickened, rough skin of persons with pellagra. In Italian, pelle means skin, and agra means sour. Pellagra remained endemic among maize-eating peasants of southern Europe for almost 2 centuries before it was recognized in the United States. In 1914, scientists suggested that pellagra was caused by a deficiency of some nutrient in the diet and that the disorder appeared to be related to black tongue (a condition analogous to pellagra) in dogs. In 1937, Conrad Elvehjem discovered that nicotinic acid cured black tongue.[4]

In the United States, pellagra was first reported in 1902. In Europe, the highest incidence was in the Mediterranean area. The first cases were reported in France in 1818, in Egypt in 1847, in England in 1866, and in Bulgaria in 1907. Over the following 2 decades, pellagra occurred in epidemic proportions in the American South. Poverty and the consumption of corn were the most frequently observed risk factors. The medical community implicated the consumption of spoiled maize as the cause of pellagra, which occurred among those who were less affluent; this suggestion caused economic repercussions for agriculturists.

Goldberger eventually solved the secret of the malady, which was a faulty diet. Goldberger was able to prevent and induce pellagra with dietary modifications, a landmark event in the annals of medicine, nutrition, and epidemiology. The reference range for serum nicotinic acid levels is 740-790 g; this level is decreased in patients with pellagra.

HIV infection induces a pellagralike state; plasma tryptophan levels are decreased in patients with HIV infection. High-dose nicotinamide treatment may successfully reverse this HIV-induced metabolic abnormality. Niacin is proposed to be a secondary preventive factor of AIDS in patients with HIV infection.[5, 6, 7]

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Pathophysiology

Pellagra is the late stage of severe niacin deficiency. Niacin, or vitamin B-3, is a water-soluble vitamin. In 1926, Goldberger reported that nicotinamide was a preventive factor of pellagra.

Pellagra can be divided into primary and secondary forms. Primary pellagra results from inadequate nicotinic acid (ie, niacin) and/or tryptophan in the diet (long-term parenteral nutrition without appropriate niacin substitution; anorexia nervosa; a self-imposed restriction diet in adult atopics with sensitizations to multiple foodstuffs). Niacin is a pyridine carboxylic acid that is converted into an amide in the body.

Niacin is required for adequate cellular function and metabolism as an essential component in coenzyme I (oxidized form of nicotinamide adenine dinucleotide [NAD]) and coenzyme II (reduced form of nicotinamide adenine dinucleotide phosphate [NADP]), which either donate or accept hydrogen ions in vital oxidation-reduction reactions. These compounds are important coenzymes for glycolysis, protein and amino acid metabolism, pyruvate metabolism, pentose biosynthesis, high-energy phosphate bond generation, glycerol metabolism, and fatty acid metabolism.

Nicotinamide has an in vitro down-regulatory effect on proinflammatory cytokines interleukin (IL)–1beta, IL-6, IL-8, IL-12, and tumor necrosis factor-alpha in a dose-dependent manner. Furthermore, it induces activation of tumor necrosis factor cachectin–induced macrophages and inhibits the expression of intercellular adhesion molecule 1 and major histocompatibility complex II. . Nicotinamide is a potent phosphodiesterase inhibitor and suppresses neutrophil chemotaxis, mast cell histamine release, and antigen-induced lymphocyte transformation. It is able to scavenge oxygen radicals and to inhibit nitric oxide synthase mRNA induction in activated macrophages. Nicotinamide increases biosynthesis of ceramides, which, upon degradation, produce sphingosine. This inhibits protein kinase C and decreases basal cell proliferation.

This immunomodulatory and anti-inflammatory effect of nicotinamide in vitro may have great potential for the treatment of human inflammatory diseases by inhibition of neutrophil chemotaxis and secretion of inflammatory cytokines, suppression of lymphocyte transformation, and inhibition of mast cell histamine release and blockade of histamine receptors. Beneficial effects of topically applied nicotinamide in aging skin, such as improvement in barrier functions in atopic dry skin and decreased appearance of signs of facial photoaging (eg, skin texture changes and hyperpigmentation), have been noted. Nicotinic acid can be formed from dietary tryptophan. Maize contains appreciable amounts of niacin, but this niacin is present in a bound form. Treating corn used for dietary staples (eg, tortillas) with lime results in the release of bound niacin.

Because cellular functions in multiple organs and tissues are affected by niacin deficiency, the clinical expressions of pellagra are diverse. Pathologic changes in the skin include vascular dilatation, proliferation of the endothelial lining, perivascular lymphocytic infiltration, hyperkeratinization, and subsequent atrophy of the epidermis. Mucosal inflammation and atrophy involve most of the GI tract. Evidence of glossitis and atrophy of the papillae of the tongue are characteristic findings, along with gastritis and subsequent gastric mucosal atrophy. Acute inflammation of the small intestine and colon are also commonly noted. Pathologic changes in the nervous system can be found in the brain, spinal cord, and peripheral nerves. Findings include patchy demyelinization and degeneration of the affected parts of the nervous system.

Secondary pellagra occurs when adequate quantities of niacin are present in the diet, but other diseases or conditions interfere with niacin absorption and/or processing. Examples of these conditions include prolonged diarrhea; chronic alcoholism; chronic dialysis treatment; chronic colitis, particularly ulcerative colitis or regional enteritis; cirrhosis of the liver; tuberculosis of the GI tract; malignant carcinoid tumor; and Hartnup syndrome. Alcoholism can be considered a risk factor for pellagra, which can, as well, be considered an alcoholism indicator.[8] Clinical manifestations of pellagra are a less sensitive indicator than biochemical niacin deficiency in carcinoid patients with carcinoid syndrome. Occasionally, an abortive form called pellagroid (eg, erythema pellagroids, pseudopellagra) is present. Hartnup syndrome is an inborn error of tryptophan metabolism.

In addition, the use of isoniazid is known to cause the symptoms of pellagra, as does the long-term administration of 5-fluorouracil. Isoniazid biochemically competes with niacin. Pellagra was also noted as a cutaneous adverse reaction after consumption of Kombucha tea.

Pellagra can develop in atopic dermatitis patients following elimination diets.[9] It is important to consider that there is some crossover of the clinical and histological features with pellagra and necrolytic migratory erythema.

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Epidemiology

Frequency

United States

The current incidence of pellagra in the United States is unknown. Epidemics of pellagra no longer occur. Sporadic cases of pellagra can be seen among patients with long-term alcoholism, food faddists, individuals dependent on illegal drugs, and patients with malabsorption states.[10, 11, 12]

International

Although the exact incidence of pellagra in other countries is not known, pellagra occurs mainly in developing nations in which corn and corn products are the major food sources, if the corn is not specially treated. Pellagra also occurs in ethnic populations whose diets are deficient in niacin and/or tryptophan.[13, 14]

Race

No racial predilection is reported.

Sex

No sex predilection is described. The only risk factor for pellagra is dietary deprivation of niacin.

Age

Pellagra is typically a disease that occurs in adults. Pellagra may develop in adolescents and young children if they are exposed to a pellagragenic diet. Pellagra rarely occurs in infants. Historically, dermatitis associated with kwashiorkor was mistaken for infantile pellagra.[15]

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Contributor Information and Disclosures
Author

Vladimir Hegyi, MD, PhD Professor, Institute of Clinical and Experimental Dermatovenereology, Slovak Republic

Vladimir Hegyi, MD, PhD is a member of the following medical societies: European Academy of Dermatology and Venereology, Slovakian Dermatovenerological Society, European Dermatology Forum

Disclosure: Nothing to disclose.

Coauthor(s)

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public Affairs and Administration

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, New York Academy of Medicine, American Academy of Dermatology, American College of Physicians, Sigma Xi

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Jeffrey J Miller, MD Associate Professor of Dermatology, Pennsylvania State University College of Medicine; Staff Dermatologist, Pennsylvania State Milton S Hershey Medical Center

Jeffrey J Miller, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Society for Investigative Dermatology, Association of Professors of Dermatology, North American Hair Research Society

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

References
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  3. Rille JH. Medizinische Gesellchaft Leipzig. Sitzug vom 16. November 1926. Ueber Pellegra (mit Lichtbildern). Dermatol Wochenschrift. 1927. 6:189.

  4. Elvehjem CA, Madden RJ, Strong FM, Woolley DW. Relation of nicotinic acid and nicotinic acid amide to canine black tongue. J Am Chem Soc. 1937. 59:1767-68.

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