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Florid Cutaneous Papillomatosis Treatment & Management

  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
Updated: Jun 24, 2016

Medical Care

Although follow-up evaluation has been limited in most reported cases of florid cutaneous papillomatosis (FCP), marked improvement of the cutaneous lesions was observed in 7 patients after they underwent surgical or chemotherapeutic treatment of the internal cancer. In at least 1 patient, local recurrence of the tumor was associated with a recurrence of florid cutaneous papillomatosis. In other cases, generalization of the cancer was associated with severe worsening of the cutaneous lesions.

To the author's knowledge, the palliative treatment of cutaneous papillomas has not produced any significant improvement, except in one patient in whom topical 5-fluorouracil was used. Such palliative treatments include systemic therapy with oral retinoids, radiation, or smallpox vaccination. Topical treatments with steroids, vitamin A acid, urea, salicylic acid, podophyllotoxin,[11] and liquid nitrogen have also been tried.


Long-Term Monitoring

Monitor patients for any recurrence of florid cutaneous papillomatosis (FCP) (assuming that it regresses after tumor therapy) because the reappearance of florid cutaneous papillomatosis can indicate a new tumor.

Contributor Information and Disclosures

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public Affairs and Administration

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, New York Academy of Medicine, American Academy of Dermatology, American College of Physicians, Sigma Xi

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Jeffrey J Miller, MD Associate Professor of Dermatology, Pennsylvania State University College of Medicine; Staff Dermatologist, Pennsylvania State Milton S Hershey Medical Center

Jeffrey J Miller, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Society for Investigative Dermatology, Association of Professors of Dermatology, North American Hair Research Society

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Takeji Nishikawa, MD Emeritus Professor, Department of Dermatology, Keio University School of Medicine; Director, Samoncho Dermatology Clinic; Managing Director, The Waksman Foundation of Japan Inc

Disclosure: Nothing to disclose.


The assistance of Edmund Janniger is greatly appreciated.

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