Jessner Lymphocytic Infiltration of the Skin Medication

  • Author: Bassam Zeina, MD, PhD; Chief Editor: William D James, MD   more...
 
Updated: Feb 13, 2012
 

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and prevent complications.

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Corticosteroids

Class Summary

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli. Oral corticosteroids should only be used in severe unremitting disease not responsive to other treatment.

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Hydrocortisone valerate (Westcort)

 

Anti-inflammatory adrenocorticosteroid derivative suitable for application to skin or external mucous membranes. May alleviate pruritus and speed resolution of lesions. Available as a 0.2% cream or ointment.

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Triamcinolone topical (Aristocort ointment, Kenalog cream)

 

For inflammatory dermatosis responsive to steroids; decreases inflammation. Intramuscular injection may be used for widespread skin disorders, or intralesional injections may be used for localized skin disorders.

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Betamethasone topical (Diprosone lotion)

 

For inflammatory dermatosis responsive to steroids; decreases inflammation. Available as 0.05% cream and ointment.

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Prednisone (Deltasone, Orasone)

 

For treating lymphocytic infiltration of the skin, when taken PO, is used alone or in combination with topical or intralesional steroids. May decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.

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Antimalarials

Class Summary

Used to treat certain photosensitive eruptions including lymphocytic infiltration of the skin.

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Hydroxychloroquine (Plaquenil)

 

Mechanism of action not fully understood. Postulates include light filtration, immunosuppression, anti-inflammatory, and DNA binding. Supplied as 200-mg tabs.

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Contributor Information and Disclosures
Author

Bassam Zeina, MD, PhD  Consulting Staff, Department of Dermatology, Milton Keynes Hospital, UK

Bassam Zeina, MD, PhD is a member of the following medical societies: British Association of Dermatologists, British Medical Association, and Royal Society of Medicine

Disclosure: Nothing to disclose.

Coauthor(s)

Nicole Sakka, MBBS  Foundation Year 2, Royal Liverpool and Broadgreen University Hospital, Liverpool, UK

Disclosure: Nothing to disclose.

Sohail Mansoor, MBBS, MSc  Dermatologist and Lead Physician in Dermatologic Surgery, Department of Dermatology, Barnet Hospital, UK

Sohail Mansoor, MBBS, MSc is a member of the following medical societies: American Academy of Anti-Aging Medicine, American Academy of Dermatology, American Society for Dermatologic Surgery, Royal College of Physicians and Surgeons of Glasgow, and Royal College of Physicians of the United Kingdom

Disclosure: Nothing to disclose.

Marjan Shah, MBBS, Msc Dermatology (UK)  Specialty Physician in Dermatology, Milton Keynes NHS Trust, UK

Disclosure: Nothing to disclose.

Specialty Editor Board

Peter Fritsch, MD  Chair, Department of Dermatology and Venereology, University of Innsbruck, Austria

Peter Fritsch, MD is a member of the following medical societies: American Dermatological Association, International Society of Pediatric Dermatology, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Richard P Vinson, MD  Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association

Disclosure: Nothing to disclose.

Daniel S Loo, MD  Associate Professor of Dermatology, Residency Program Director, Department of Dermatology, Tufts Medical Center

Daniel S Loo, MD is a member of the following medical societies: American Academy of Dermatology and Association of Professors of Dermatology

Disclosure: Nothing to disclose.

Glen H Crawford, MD  Assistant Clinical Professor, Department of Dermatology, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, The Pennsylvania Hospital

Glen H Crawford, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Phi Beta Kappa, and Society of USAF Flight Surgeons

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD  Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology and Society for Investigative Dermatology

Disclosure: Elsevier Royalty Other

Additional Contributors

The authors and editors of eMedicine gratefully acknowledge the contributions of previous author, Mohsin Ali, MBBS, FRCP, MRCP, to the development and writing of this article.

References

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  16. Arai E, Shimizu M, Hirose T. A review of 55 cases of cutaneous lymphoid hyperplasia: reassessment of the histopathologic findings leading to reclassification of 4 lesions as cutaneous marginal zone lymphoma and 19 as pseudolymphomatous folliculitis. Hum Pathol. May 2005;36(5):505-11. [Medline].

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  21. Lever WF, Lever GS. Connective Tissue Diseases. In: Histopathology of the Skin. Baltimore, Md: Lippincott Williams & Wilkins; 1990:505-06.

  22. Lipsker D, Mitschler A, Grosshans E, Cribier B.Could Jessner's lymphocytic infiltrate of the skin be a dermal variant of lupus erythematosus? An analysis of 210 cases.Dermatology. 2006;213(1):15-22 [database online].

  23. Mackie RM. Cutaneous Lymphomas and Lymphocytic Infiltrates. In: Textbook of Dermatology. Vol. 3. London, England: Blackwell Science; 1998:2400-01.

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  26. Toonstra J, Wildschut A, Boer J, Smeenk G, Willemze R, van der Putte SC, et al. Jessner's lymphocytic infiltration of the skin. A clinical study of 100 patients. Arch Dermatol. Nov 1989;125(11):1525-30. [Medline].

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  28. Wolf M. Lymphocytic infiltration of the face. Arch Dermatol. 1957;75:136.

 
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