eMedicine Specialties > Dermatology > Malignant Neoplasms
Erythroplasia of Queyrat (Bowen Disease of the Glans Penis): Differential Diagnoses & Workup
Updated: Jan 15, 2008
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
- Multimedia
Differential Diagnoses
Other Problems to Be Considered
The following mnemonic (FAINT) may be helpful:
Fixed drug eruption or other drug-induced dermatoses
Allergic/irritant contact dermatitis
Infection
Neoplasia
Trauma
Other problems to consider include psoriatic/systemic disorders and balanitis (specific types).2
Workup
Laboratory Studies
Diagnosis of EQ must be made via skin biopsy of the affected area. Pay special attention to areas of ulceration or distinct papillomatous lesions, and palpate inguinal nodes. The following diagnostic procedures may be useful in excluding other infectious processes:
- Bacterial/viral/fungal culture
- Tzanck preparation
- Potassium hydroxide examination
- Gram stain
Histologic Findings
The epidermis shows acanthosis and loss of normal architecture. It is replaced by atypical hyperplastic keratinocytes characterized by disorientation, dyskeratosis, and mitotic figures. The rete ridges appear elongated and thickened with intervening dermal papillae reduced to thin strands.
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Differential Diagnoses & Workup: Erythroplasia of Queyrat (Bowen Disease of the Glans Penis) |
| Treatment & Medication: Erythroplasia of Queyrat (Bowen Disease of the Glans Penis) |
| Follow-up: Erythroplasia of Queyrat (Bowen Disease of the Glans Penis) |
| Multimedia: Erythroplasia of Queyrat (Bowen Disease of the Glans Penis) |
| References |
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References
Goette DK. Review of erythroplasia of Queyrat and its treatment. Urology. Oct 1976;8(4):311-5. [Medline].
Davis-Daneshfar A, Trüeb RM. Bowen's disease of the glans penis (erythroplasia of Queyrat) in plasma cell balanitis. Cutis. Jun 2000;65(6):395-8. [Medline].
Arlette JP. Treatment of Bowen's disease and erythroplasia of Queyrat. Br J Dermatol. Nov 2003;149 Suppl 66:43-9. [Medline].
Harrington KJ, Price PM, Fry L, Witherow RO. Erythroplasia of Queyrat treated with isotretinoin. Lancet. Oct 16 1993;342(8877):994-5. [Medline].
Orengo I, Rosen T, Guill CK. Treatment of squamous cell carcinoma in situ of the penis with 5% imiquimod cream: a case report. J Am Acad Dermatol. Oct 2002;47(4 Suppl):S225-8. [Medline].
Micali G, Nasca MR, De Pasquale R. Erythroplasia of Queyrat treated with imiquimod 5% cream. J Am Acad Dermatol. Nov 2006;55(5):901-3. [Medline].
Lee MR, Ryman W. Erythroplasia of Queyrat treated with topical methyl aminolevulinate photodynamic therapy. Australas J Dermatol. Aug 2005;46(3):196-8. [Medline].
Brown MD, Zachary CB, Grekin RC, Swanson NA. Genital tumors: their management by micrographic surgery. J Am Acad Dermatol. Jan 1988;18(1 Pt 1):115-22. [Medline].
Conejo-Mir JS, Muñoz MA, Linares M, Rodríguez L, Serrano A. Carbon dioxide laser treatment of erythroplasia of Queyrat: a revisited treatment to this condition. J Eur Acad Dermatol Venereol. Sep 2005;19(5):643-4. [Medline].
Gerber GS. Carcinoma in situ of the penis. J Urol. Apr 1994;151(4):829-33. [Medline].
Graham JH, Helwig EB. Erythroplasia of Queyrat. A clinicopathologic and histochemical study. Cancer. Dec 1973;32(6):1396-414. [Medline].
Further Reading
Keywords
carcinoma in situ of the penis, Bowen disease, penile carcinoma, penile neoplasia, EQ, erythroplasia of the glans penis, uncircumcised men, erythematous plaques, penile Bowen disease, papillomavirus-induced carcinoma in situ
Differential Diagnoses & Workup: Erythroplasia of Queyrat (Bowen Disease of the Glans Penis)