Medscape is available in 5 Language Editions – Choose your Edition here.


Erythroplasia of Queyrat (Bowen Disease of the Glans Penis) Medication

  • Author: Vikas Shrivastava, MD; Chief Editor: Dirk M Elston, MD  more...
Updated: Mar 31, 2016

Medication SummaryAntineoplastic agentsImmune response modifiers

Several case reports describe limited success in treating selected superficial lesions of erythroplasia of Queyrat (Bowen disease of the glans penis) with topical 5-fluorouracil 5% cream.

Several case reports and series describe successful treatment of noninvasive erythroplasia of Queyrat (Bowen disease of the glans penis) with topical imiquimod 5% cream.

Contributor Information and Disclosures

Vikas Shrivastava, MD Resident Physician, Department of Dermatology, Naval Medical Center San Diego

Disclosure: Nothing to disclose.


Kimberly L Maino, MD Mohs Surgeon and Dermatologist, Aurora Skin Care Center

Kimberly L Maino, MD is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Surgery, American Medical Association, Women's Dermatologic Society

Disclosure: Nothing to disclose.

Kendall M Egan, MD, FAAD Dermatologist, Veteran's Affairs Medical Center; Dermatologist, Spruce Health, Dermatologist, DermOne

Kendall M Egan, MD, FAAD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Association of Military Dermatologists

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Mark W Cobb, MD Consulting Staff, WNC Dermatological Associates

Mark W Cobb, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Society of Dermatopathology

Disclosure: Nothing to disclose.


Mary Farley, MD Dermatologic Surgeon/Mohs Surgeon, Anne Arundel Surgery Center

Disclosure: Nothing to disclose.

Joseph L Wilde, MD Chief, Department of Dermatology, Vicenza Army Health Center, Italy

Joseph L Wilde is a member of the following medical societies: American College of Mohs Micrographic Surgery and Cutaneous Oncology

Disclosure: Nothing to disclose.


The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of the Navy, Department of the Army, Department of Defense, or the US Government. The authors are employees of the US Government and military service members. This work was prepared as part of their official duties. Title 17, USC, § 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17, USC, § 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties.

  1. Kirnbauer R, Lenz P, Bolognia J, Jorizzo J, and Schaffer J. Human Papillomaviruses. Dermatology. 3rd ed. Philadelphia, Pa: Elsevier Saunders; 2012. Vol 2: 1309-20.

  2. Micali G, Innocenzi D, Nasca MR, Musumeci ML, Ferrau F, Greco M. Squamous cell carcinoma of the penis. J Am Acad Dermatol. 1996 Sep. 35(3 Pt 1):432-51. [Medline].

  3. Henquet CJ. Anogenital malignancies and pre-malignancies. J Eur Acad Dermatol Venereol. 2011 Aug. 25(8):885-95. [Medline].

  4. Goette DK. Review of erythroplasia of Queyrat and its treatment. Urology. 1976 Oct. 8(4):311-5. [Medline].

  5. Kutlubay Z, Engin B, Zara T, Tüzün Y. Anogenital malignancies and premalignancies: facts and controversies. Clin Dermatol. 2013 Jul-Aug. 31(4):362-73. [Medline].

  6. Ruocco E, Brunetti G, Del Vecchio M, Ruocco V. The practical use of cytology for diagnosis in dermatology. J Eur Acad Dermatol Venereol. 2011 Feb. 25(2):125-9. [Medline].

  7. Divakaruni AK, Rao AV, Mahabir B. Erythroplasia of Queyrat with Zoon's balanitis: a diagnostic dilemma. Int J STD AIDS. 2008 Dec. 19(12):861-3. [Medline].

  8. Graham JH, Helwig EB. Erythroplasia of Queyrat. A clinicopathologic and histochemical study. Cancer. 1973 Dec. 32(6):1396-414. [Medline].

  9. Johnston RB and Weedon D. Tumors of the Epidermis. Weedon's Skin Pathology Essentials. Edinburgh: Elsevier Churchill Livingstone; 2012. 31.

  10. Fanning DM, Flood H. Erythroplasia of queyrat. Clin Pract. 2012 May 29. 2(3):e63. [Medline]. [Full Text].

  11. Wieland U, Jurk S, Weissenborn S, Krieg T, Pfister H, Ritzkowsky A. Erythroplasia of queyrat: coinfection with cutaneous carcinogenic human papillomavirus type 8 and genital papillomaviruses in a carcinoma in situ. J Invest Dermatol. 2000 Sep. 115(3):396-401. [Medline].

  12. Nasca MR, Potenza MC, Alessi L, Paravizzini G, Micali G. Absence of PCR-detectable human papilloma virus in erythroplasia of Queyrat using a comparative control group. Sex Transm Infect. 2010 Jun. 86(3):199-201. [Medline].

  13. Schmitz L, Bierhoff E, Dirschka T. Optical coherence tomography imaging of erythroplasia of Queyrat and treatment with imiquimod 5% cream: a case report. Dermatology. 2014. 228 (1):24-6. [Medline].

  14. Harrington KJ, Price PM, Fry L, Witherow RO. Erythroplasia of Queyrat treated with isotretinoin. Lancet. 1993 Oct 16. 342(8877):994-5. [Medline].

  15. Micali G, Nasca MR, De Pasquale R. Erythroplasia of Queyrat treated with imiquimod 5% cream. J Am Acad Dermatol. 2006 Nov. 55(5):901-3. [Medline].

  16. Conejo-Mir JS, Munoz MA, Linares M, Rodriguez L, Serrano A. Carbon dioxide laser treatment of erythroplasia of Queyrat: a revisited treatment to this condition. J Eur Acad Dermatol Venereol. 2005 Sep. 19(5):643-4. [Medline].

  17. Arlette JP. Treatment of Bowen's disease and erythroplasia of Queyrat. Br J Dermatol. 2003 Nov. 149 Suppl 66:43-9. [Medline].

  18. Orengo I, Rosen T, Guill CK. Treatment of squamous cell carcinoma in situ of the penis with 5% imiquimod cream: a case report. J Am Acad Dermatol. 2002 Oct. 47(4 Suppl):S225-8. [Medline].

  19. Micali G, Lacarrubba F, Dinotta F, Massimino D, Nasca MR. Treating skin cancer with topical cream. Expert Opin Pharmacother. 2010 Jun. 11(9):1515-27. [Medline].

  20. Deen K, Burdon-Jones D. Imiquimod in the treatment of penile intraepithelial neoplasia: An update. Australas J Dermatol. 2016 Mar 8. [Medline].

  21. Gerber GS. Carcinoma in situ of the penis. J Urol. 1994 Apr. 151(4):829-33. [Medline].

  22. Brown MD, Zachary CB, Grekin RC, Swanson NA. Genital tumors: their management by micrographic surgery. J Am Acad Dermatol. 1988 Jan. 18(1 Pt 1):115-22. [Medline].

  23. Feldmeyer L, Krausz-Enderlin V, Töndury B, et al. Methylaminolaevulinic acid photodynamic therapy in the treatment of erythroplasia of Queyrat. Dermatology. 2011. 223(1):52-6. [Medline].

  24. van Bezooijen BP, Horenblas S, Meinhardt W, Newling DW. Laser therapy for carcinoma in situ of the penis. J Urol. 2001 Nov. 166(5):1670-1. [Medline].

  25. Del Losada JP, Ferré A, San Román B, Vieira V, Fonseca E. Erythroplasia of Queyrat with urethral involvement: treatment with carbon dioxide laser vaporization. Dermatol Surg. 2005 Nov. 31(11 Pt 1):1454-7. [Medline].

  26. Yamaguchi Y, Hata H, Imafuku K, Kitamura S, Shimizu H. A case of erythroplasia of Queyrat successfully treated with combination carbon dioxide laser vaporization and surgery. J Eur Acad Dermatol Venereol. 2016 Mar. 30 (3):497-8. [Medline].

  27. Lee MR, Ryman W. Erythroplasia of Queyrat treated with topical methyl aminolevulinate photodynamic therapy. Australas J Dermatol. 2005 Aug. 46(3):196-8. [Medline].

  28. Davis-Daneshfar A, Trueb RM. Bowen's disease of the glans penis (erythroplasia of Queyrat) in plasma cell balanitis. Cutis. 2000 Jun. 65(6):395-8. [Medline].

  29. Fai D, Romano I, Cassano N, Vena GA. Methyl-aminolevulinate photodynamic therapy for the treatment of erythroplasia of Queyrat in 23 patients. J Dermatolog Treat. 2011 Sep 4. [Medline].

  30. Calzavara-Pinton PG, Rossi MT, Sala R. A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 2: oncologic and infectious indications. Photochem Photobiol Sci. 2013 Jan. 12(1):158-65. [Medline].

  31. Porter WM, Francis N, Hawkins D, Dinneen M, Bunker CB. Penile intraepithelial neoplasia: clinical spectrum and treatment of 35 cases. Br J Dermatol. 2002 Dec. 147(6):1159-65. [Medline].

  32. Kim B, Garcia F, Toma N, et al. A rare case of penile cancer in siu metastasizing to lymph nodes. Can Urol Assoc J. 2007. 1:404-7.

Erythroplasia of Queyrat. Courtesy of Hon Pak, MD.
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.