Premalignant Fibroepithelial Tumor (Pinkus Tumor) Treatment & Management
- Author: Darius Mehregan, MD; Chief Editor: Dirk M Elston, MD more...
Medical Care
Treatment is primarily surgical. In rare instances, intralesional or topical chemotherapy may be useful.
Surgical Care
Options for treatment are similar to those for other forms of basal cell carcinoma , and the clinician's choice will likely be case dependent. Recommended treatment options include complete surgical excision or electrodesiccation followed by curettage. Cryosurgery, Mohs micrographic surgery , or radiation therapy may also be used.
Pinkus H. Premalignant fibroepithelial tumors of skin. AMA Arch Derm Syphilol. Jun 1953;67(6):598-615. [Medline].
Matsumura Y, Nishigori C, Yagi T, Imamura S, Takebe H. Characterization of p53 gene mutations in basal-cell carcinomas: comparison between sun-exposed and less-exposed skin areas. Int J Cancer. Mar 15 1996;65(6):778-80. [Medline].
Aszterbaum M, Rothman A, Johnson RL, Fisher M, Xie J, Bonifas JM, et al. Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol. Jun 1998;110(6):885-8. [Medline].
Sellheyer K, Nelson P, Kutzner H. Fibroepithelioma of Pinkus is a true basal cell carcinoma developing in association with a newly identified tumour-specific type of epidermal hyperplasia. Br J Dermatol. Jan 2012;166(1):88-97. [Medline].
Tarallo M, Cigna E, Fino P, Lo Torto F, Corrias F, Scuderi N. Fibroepithelioma of Pinkus: variant of basal cell carcinoma or trichoblastoma? Case report. G Chir. Jun-Jul 2011;32(6-7):326-8. [Medline].
Ioannidis O, Papaemmanuil S, Kakoutis E, Papadopoulos G, Chatzopoulos S, Kotronis A, et al. Fibroepithelioma of pinkus in continuity with nodular basal cell carcinoma: supporting evidence of the malignant nature of the disease. Pathol Oncol Res. Mar 2011;17(1):155-7. [Medline].
Stern JB, Haupt HM, Smith RR. Fibroepithelioma of Pinkus. Eccrine duct spread of basal cell carcinoma. Am J Dermatopathol. Dec 1994;16(6):585-7. [Medline].
Pan Z, Huynh N, Sarma DP. Fibroepithelioma of pinkus in a 9-year-old boy: a case report. Cases J. 2008;1(1):21. [Medline].
Hartschuh W, Schulz T. Merkel cell hyperplasia in chronic radiation-damaged skin: its possible relationship to fibroepithelioma of Pinkus. J Cutan Pathol. Sep 1997;24(8):477-83. [Medline].
Bryant J. Fibroepithelioma of Pinkus overlying breast cancer. Arch Dermatol. Mar 1985;121(3):310. [Medline].
Warner TF, Burgess H, Mohs FE. Extramammary Paget's disease in fibroepithelioma of Pinkus. J Cutan Pathol. Oct 1982;9(5):340-4. [Medline].
Heymann WR, Soifer I, Burk PG. Penile premalignant fibroepithelioma of Pinkus. Cutis. May 1983;31(5):519-21. [Medline].
Zalaudek I, Leinweber B, Ferrara G, Soyer HP, Ruocco E, Argenziano G. Dermoscopy of fibroepithelioma of pinkus. J Am Acad Dermatol. Jan 2005;52(1):168-9. [Medline].
Naeyaert JM, Pauwels C, Geerts ML, Verplancke P. CD-34 and Ki-67 staining patterns of basaloid follicular hamartoma are different from those in fibroepithelioma of Pinkus and other variants of basal cell carcinoma. J Cutan Pathol. Nov 2001;28(10):538-41. [Medline].
Katona TM, Ravis SM, Perkins SM, Moores WB, Billings SD. Expression of androgen receptor by fibroepithelioma of Pinkus: evidence supporting classification as a basal cell carcinoma variant?. Am J Dermatopathol. Feb 2007;29(1):7-12. [Medline].
Barr RJ, Herten RJ, Stone OJ. Multiple premalignant fibroepitheliomas of Pinkus: a case report and review of the literature. Cutis. Mar 1978;21(3):335-7. [Medline].
Jaffe ES. Premalignant fibroepithelioma of Pinkus. Arch Dermatol. 1964;89:768.
Lever WF, Schaumberg-Lever G. Fibroepithelioma. In: Histopathology of the Skin. Philadelphia, Pa: Lippincott; 1983:570.
Mehregan AH. Proliferation of sweat ducts in certain diseases of the skin. Am J Dermatopathol. 1981;3(1):27-31. [Medline].
Val-Bernal JF, Gómez-Ortega JM, Fernández-Llaca H, Gómez-Román JJ. Fibroepithelioma of pinkus with tumor giant cells. Am J Dermatopathol. Aug 2002;24(4):336-9. [Medline].

