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Microcystic Adnexal Carcinoma Differential Diagnoses

  • Author: Nektarios I Lountzis, MD; Chief Editor: Dirk M Elston, MD  more...
 
Updated: Jun 27, 2016
 
 

Diagnostic Considerations

Also consider the following:

  • Desmoplastic trichoepithelioma
  • Syringoma
  • Morpheaform/infiltrative/sclerosing basal cell carcinoma
  • Squamous cell carcinoma (poorly differentiated, with or without ductal differentiation)
  • Adenosquamous carcinoma
  • Eccrine epithelioma
  • Squamoid eccrine ductal carcinoma
  • Trichoadenoma
  • Cutaneous metastases of breast carcinoma
  • Cutaneous metastases of microcystic squamous cell carcinoma of the lung[35]
  • Other metastatic adenocarcinomas
  • Sweat duct proliferation associated with atrophodermia vermiculata[36]

Differential Diagnoses

 
 
Contributor Information and Disclosures
Author

Nektarios I Lountzis, MD Consulting Staff, Advanced Dermatology Associates, Ltd, Lehigh Valley Health Network

Nektarios I Lountzis, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, American Contact Dermatitis Society, International Society of Dermatopathology

Disclosure: Nothing to disclose.

Coauthor(s)

Mary Grace Petrick, MD Consulting Staff, Department of Dermatology, Geisinger Medical Center

Mary Grace Petrick, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery

Disclosure: Nothing to disclose.

Specialty Editor Board

Michael J Wells, MD, FAAD Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Kelly M Cordoro, MD Assistant Professor of Clinical Dermatology and Pediatrics, Department of Dermatology, University of California, San Francisco School of Medicine

Kelly M Cordoro, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Medical Society of Virginia, Society for Pediatric Dermatology, Women's Dermatologic Society, Association of Professors of Dermatology, National Psoriasis Foundation, Dermatology Foundation

Disclosure: Nothing to disclose.

Acknowledgements

Mary Farley, MD Dermatologic Surgeon/Mohs Surgeon, Anne Arundel Surgery Center

Disclosure: Nothing to disclose.

Bruce C Gee, MBBCh, MRCP Specialist Registrar, Department of Dermatology, Queen's Medical Centre, UK

Bruce C Gee, MBBCh, MRCP is a member of the following medical societies: Royal College of Physicians

Disclosure: Nothing to disclose.

Kevin Hollowood, MD, MBBS, MRCP, FRCPath Consulting Staff, Department of Pathology, John Radcliffe Hospital of Oxford, UK

Disclosure: Nothing to disclose.

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Clinical photo of a microcystic adnexal carcinoma on the left upper lip of an elderly woman. Note the close clinical resemblance to basal cell carcinoma. Courtesy of Dirk M. Elston, MD.
A low-power view of microcystic adnexal carcinoma demonstrates superficially located keratocysts and variably sized tumor nests and ducts. Note the diminution in size of the nests and cysts with the depth of dermal invasion. Courtesy of Dirk M. Elston, MD
Small ductular structures lined by 2-3 cell layers of small eosinophilic cells showing little pleomorphism set in a dense fibrous stroma. Courtesy of Dirk M. Elston, MD.
A high-power view of small, irregularly shaped nests and strands of small tumor cells without obvious ductal formation. Courtesy of Dirk M. Elston, MD.
 
 
 
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