Acrodermatitis enteropathica is a rare inherited form of zinc deficiency, characterized by periorificial and acral dermatitis, alopecia, and diarrhea.
Acrodermatitis enteropathica is an autosomal recessive disorder postulated to occur as a result of mutations in the SLC39A4 gene located on band 8q24.3. [3, 4, 5] The SLC39A4 gene encodes a transmembrane protein that is part of the zinc/iron-regulated transporter–like protein (ZIP) family required for zinc uptake. [6, 7] This protein is highly expressed in the enterocytes in the duodenum and jejunum [8, 9] ; therefore, affected individuals have a decreased ability to absorb zinc from dietary sources. Absence of a binding ligand needed to transport zinc may further contribute to zinc malabsorption. 
Differentiating acquired zinc deficiency disorders from acrodermatitis enteropathica is difficult because they have similar clinical presentations. Acquired zinc deficiency can occur as a result of low nutritional intake, malabsorption, excessive loss of zinc, or a combination of these factors.  Acrodermatitis enteropathica can only be accurately diagnosed after attempts to remove zinc supplementation have failed.  Importantly, transient acquired zinc deficiencies can occur in premature infants secondary to their greater physiological demand for zinc and lower body stores. [13, 14] Additionally, zinc deficiency can present in full-term breastfed infants as a result of low maternal serum zinc levels or a defect in mammary zinc secretion. [1, 15] Thus, not all infants who have an acrodermatitis enteropathica–like presentation have the genetic disorder. Also see the Pediatrics article Acrodermatitis Enteropathica.
The frequency of acrodermatitis enteropathica is unknown.
An estimated 1 in 500,000 people in Denmark are affected by acrodermatitis enteropathica. 
Acrodermatitis enteropathica has no racial predilection.
Acrodermatitis enteropathica has no sexual predilection.
Acrodermatitis enteropathica typically appears in the first few weeks after birth if the child is fed bovine milk or shortly after cessation of breastfeeding.  Acrodermatitis enteropathica can occur in children who are still breastfeeding if the levels of zinc are low in the breast milk. 
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