eMedicine Specialties > Dermatology > Metabolic Diseases

Amyloidosis, Nodular Localized Cutaneous: Follow-up

Author: Lauren Biesbroeck, Washington University in St Louis School of Medicine
Coauthor(s): Gregory J Raugi, MD, PhD, Professor, Department of Internal Medicine, Division of Dermatology, University of Washington at Seattle; Chief, Dermatology Section, Primary and Specialty Care Service, Veterans Administration Medical Center of Seattle
Contributor Information and Disclosures

Updated: Jan 5, 2010

Follow-up

Complications

  • Rarely, patients with nodular localized cutaneous amyloidosis develop systemic amyloidosis or multiple myeloma years later, suggesting the need for follow-up care.

Prognosis

  • Nodular localized cutaneous amyloidosis typically is benign and limited to the skin. Progression to systemic disease is unlikely. Previous articles have reported progression rates as high as 50%.2 However, a more recent review article reports that less than 15% of patients later developed systemic amyloidosis. Other, more recent case series have shown rates of progression of 7%.3

Miscellaneous

Medicolegal Pitfalls

  • Since nodular localized cutaneous amyloidosis is rare, recognizing that the disease exists is key. Perform or refer patients for adequate biopsy. Once the diagnosis is established, testing for multiple myeloma with serum and urine protein electrophoresis is prudent. Do not confuse generally localized disease with systemic amyloidosis, although the possibility of developing systemic disease is remote.
 
Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous author, Marion C. Miethke, MD, to the development and writing of this article.



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References
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References

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  2. Kalajian AH, Waldman M, Knable AL. Nodular primary localized cutaneous amyloidosis after trauma: a case report and discussion of the rate of progression to systemic amyloidosis. J Am Acad Dermatol. Aug 2007;57(2 Suppl):S26-9. [Medline].

  3. Woollons A, Black MM. Nodular localized primary cutaneous amyloidosis: a long-term follow-up study. Br J Dermatol. Jul 2001;145(1):105-9. [Medline].

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Further Reading

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Keywords

nodular localized cutaneous amyloidosis, localized cutaneous amyloidosis, NLCA, LCA, amyloidosis cutis nodularis atrophicans, tumefactive amyloid, systemic amyloidosis, Sjogren syndrome, Sjögren syndrome

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Contributor Information and Disclosures

Author

Lauren Biesbroeck, Washington University in St Louis School of Medicine
Disclosure: Nothing to disclose.

Coauthor(s)

Gregory J Raugi, MD, PhD, Professor, Department of Internal Medicine, Division of Dermatology, University of Washington at Seattle; Chief, Dermatology Section, Primary and Specialty Care Service, Veterans Administration Medical Center of Seattle
Gregory J Raugi, MD, PhD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

Medical Editor

Catharine Lisa Kauffman, MD, FACP, Georgetown Dermatology and Georgetown Dermpath
Catharine Lisa Kauffman, MD, FACP is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Royal Society of Medicine, Society for Investigative Dermatology, and Women's Dermatologic Society
Disclosure: Nothing to disclose.

Pharmacy Editor

Richard P Vinson, MD, Assistant Clinical Professor, Department of Dermatology, Texas Tech University School of Medicine; Consulting Staff, Mountain View Dermatology, PA
Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association
Disclosure: Nothing to disclose.

Managing Editor

Warren R Heymann, MD, Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey
Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology
Disclosure: Nothing to disclose.

CME Editor

Catherine M Quirk, MD, Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania
Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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