Nodular Localized Cutaneous Amyloidosis Treatment & Management
- Author: Nicholas V Nguyen, MD; Chief Editor: Dirk M Elston, MD more...
Various methods attempt to improve the appearance of the nodular localized cutaneous amyloidosis lesions, including topical and intralesional corticosteroids, cryotherapy, dermabrasion, shaving, curettage and electrodesiccation, carbon dioxide laser,[22, 23, 24] and pulsed dye laser. However, lesions frequently recur after treatment. Topical and intralesional corticosteroids and cryotherapy usually are not helpful. One attempt at cryotherapy produced pinpoint bleeding. Recently, a solitary report has described successful treatment with cyclophosphamide in a patient with both CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia) and Sjögren syndrome.
Rarely, patients with nodular localized cutaneous amyloidosis develop systemic amyloidosis or multiple myeloma years later, suggesting the need for follow-up care.
Procedures may include the following:
- Procedures such as excision and curettage and electrodessication have provided satisfactory cosmetic results for nodular localized cutaneous amyloidosis.
- Laser treatment has been described in nodular localized cutaneous amyloidosis.
- Excessive tissue friability and difficulty with intraoperative hemostasis were described while treating one nasal lesion with carbon dioxide laser; however, a good cosmetic result was achieved.
- A patient treated with a tunable dye laser had a good result, and clinical improvement was maintained over 6 months.
None of these treatment methods totally eradicates lesions, which can recur.
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