eMedicine Specialties > Dermatology > Mycobacterial Infections
Papulonecrotic Tuberculids
Updated: Jul 9, 2009
Introduction
Background
The tuberculids, first described by Darier in 1896, represent a form of cutaneous hypersensitivity reaction to tuberculosis (TB) antigens.1 Although many types of tuberculids have been described, most are now understood to not be uniquely caused by tuberculosis. However, papulonecrotic tuberculids (PNTs) and lichen scrofulosorum are still widely accepted as true tuberculids.
The entity papulonecrotic tuberculid was first established by Pautrier in 1936 as a distinct tuberculosis-associated disorder, when he described the characteristic clinical and histopathologic features. Papulonecrotic tuberculid is a chronic, recurrent, and symmetric eruption of necrotizing skin papules arising in crops, involving primarily the arms and the legs. A hallmark of this condition is that lesions heal with varioliform scarring. The eruption is believed to represent a hypersensitivity reaction to tuberculosis antigens released from a distant focus of infection. Most patients react markedly to the Mantoux skin test (purified protein derivative, PPD) and may exhibit other evidence of current or past tuberculosis infection.
Pathophysiology
The pathophysiology of papulonecrotic tuberculid is controversial. Most authors believe this disease entity is triggered by an initial Arthus reaction to mycobacterial antigens. This is then followed by a hypersensitivity reaction in which antigens undergo opsonization by antibodies, followed by immune complex deposition in small cutaneous blood vessels. The ensuing complement cascade triggers a leukocytoclastic vasculitis, leading to destruction of vessel walls with ensuing tissue necrosis. However, other authors dispute this mechanism, citing the lack of leukocytoclastic vasculitis in some cases. Instead, they propose that the primary lesion is the result of subacute lymphohistiocytic vasculitis that leads to thrombosis and subsequent tissue necrosis.
Whatever underlies the pathophysiology, a consensus has been reached that papulonecrotic tuberculid represents a true hypersensitivity reaction rather than the result of a local cutaneous tuberculosis infection. This is based on the observation that papulonecrotic tuberculid lesions have consistently failed to either stain positive for, or culture out, mycobacterial organisms. Although the organisms are absent, mycobacterial DNA have been detected in approximately half of the biopsy specimens subjected to polymerase chain reaction. These observations support the idea that lesions of papulonecrotic tuberculid are the result of released mycobacterial antigens in the setting of a concurrent but distant infection.
Frequency
United States
A decreasing incidence of papulonecrotic tuberculid began in the second half of the 1900s and the decline continues to this day. This phenomenon is attributed to aggressive tuberculosis control now found in wide practice. Currently, almost all cases come from areas outside of North America with high endemic rates of tuberculosis. However, a rare US case, involving a previously healthy 9-year-old girl from Chicago, Ill, was reported in 1990.2 Historically, reports indicate that young women and children are especially susceptible to this disorder.
Papulonecrotic tuberculid–like lesions have also been associated with other mycobacterial infections, including Mycobacterium bovis and Mycobacterium kansasii, and from BCG vaccination.3 With the increased incidence of tuberculosis infection in patients with HIV,4 the frequency of papulonecrotic tuberculid may increase, although this has not yet occurred, due possibly to effective public health measures to identify, isolate, and treat active cases of tuberculosis.
International
Papulonecrotic tuberculid is an uncommon disorder even in populations with a high prevalence of tuberculosis, occurring in less than 5% of active tuberculosis cases. In the literature, 91 cases were reported during a 17-year period in South Africa in 1974. In addition, 12 cases from a period of longer than 30 years in England were reported in 1986. In the latter study, most patients were immigrants and had presumably acquired the infection outside of England. Freiman et al reported a case in a 25-year-old woman from the Philippines who had immigrated to Canada 8 years previously.5
Mortality/Morbidity
The condition typically follows a prolonged and relapsing course lasting years, although spontaneous resolution has been reported. Significant varioliform scarring is a sequela, and progression to lupus vulgaris has been observed.6,7 An association with Takayasu arteritis of the aortic arch has also been documented.
Sex
Females seem to be at a slightly increased risk for developing this disorder.
Age
Children and young adults are more susceptible to this condition than other people. In the 1974 study from South Africa, two thirds of the patients were younger than 30 years.
Clinical
History
- The characteristic lesions are small, erythematous, inflammatory papules that undergo central ulceration and heal spontaneously within weeks, leaving a varioliform scar.
- Lesions arise in symmetric crops, typically with an acral predilection. Characteristically, lesions develop over the extensor surfaces, particularly the knees, the elbows, and the dorsum of the hands and the feet, although widespread involvement may be present.
- New lesions form as older lesions resolve, giving the eruption a polymorphous appearance.
- Oral lesions have not been reported to date.
- Papulonecrotic tuberculids have been reported to coexist with lesions of erythema induratum,8 as well as lichen scrofulosorum.9 In several reports, cutaneous lesions resolved with appropriate antituberculosis therapy.
Physical
- Primary lesion: The characteristic initial lesions are 2- to 8-mm, erythematous papules that become pustules and undergo central ulceration forming hemorrhagic-crusted papules.
- Distribution: Lesions arise in symmetric crops, typically with an acral predilection. Characteristically, lesions develop over the extensor surfaces, particularly the knees, the elbows, and the dorsum of the hands and the feet, although widespread involvement may occur. Involvement of the glans penis has also been reported.
- Color: Hyperpigmented to erythematous papules with central crusting are seen early, and the lesions generally heal with scarring.
- Lymph nodes: In one study, as many as one third of the cases were associated with cervical lymphadenopathy, and some patients developed scrofuloderma.
Causes
The eruption is a form of an exaggerated host immunologic response to a mycobacterial infection involving the cutaneous vessels. Active tuberculosis is reported in as many as 40% of patients.
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References
Darier MJ. Des "tuberculides" cutanees. Ann Dermatol Syph. 1896;7:1431-36.
Sloan JB, Medenica M. Papulonecrotic tuberculid in a 9-year-old American girl: case report and review of the literature. Pediatr Dermatol. Sep 1990;7(3):191-5. [Medline].
Iden DL, Rogers RS 3rd, Schroeter AL. Papulonecrotic tuberculid secondary to Mycobacterium bovis. Arch Dermatol. Apr 1978;114(4):564-6. [Medline].
Fernandes C, Maltez F, Lourenco S, Morgado A, Proenca R. Papulonecrotic tuberculid in a human immunodeficiency virus type-1 patient with multidrug-resistant tuberculosis. J Eur Acad Dermatol Venereol. May 2004;18(3):369-70. [Medline].
Freiman A, Ting P, Miller M, Greenaway C. Papulonecrotic tuberculid: a rare form of cutaneous tuberculosis. Cutis. Jun 2005;75(6):341-6. [Medline].
Morrison JG, Fourie ED. The papulonecrotic tuberculide. From Arthus reaction to lupus vulgaris. Br J Dermatol. Sep 1974;91(3):263-70. [Medline].
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Thappa DM, Karthikeyan K, Jayanthi S. Tuberculid in a child: transformation from papulonecrotic to lichen scrofulosorum. Pediatr Dermatol. Jan-Feb 2003;20(1):91-3. [Medline].
Chalermdamrichai P, Puavilai S, Jerasutus S, Boonsarngsuk V, Kiattboonsri S, Suwatanapongched T. Sarcoidosis presenting as papulonecrotic tuberculid-like lesions: report of a case. J Med Assoc Thai. Jul 2004;87(7):839-44. [Medline].
[Guideline] Taylor Z, Nolan CM, Blumberg HM. Controlling tuberculosis in the United States. Recommendations from the American Thoracic Society, CDC, and the Infectious Diseases Society of America. MMWR Recomm Rep. Nov 4 2005;54:1-81. [Medline].
[Guideline] Guidelines for the investigation of contacts of persons with infectious tuberculosis. Recommendations from the National Tuberculosis Controllers Association and CDC. MMWR Recomm Rep. Dec 16 2005;54:1-47. [Medline].
Barbagallo J, Tager P, Ingleton R, Hirsch RJ, Weinberg JM. Cutaneous tuberculosis: diagnosis and treatment. Am J Clin Dermatol. 2002;3(5):319-28. [Medline].
Jordaan HF, Van Niekerk DJ, Louw M. Papulonecrotic tuberculid. A clinical, histopathological, and immunohistochemical study of 15 patients. Am J Dermatopathol. Oct 1994;16(5):474-85. [Medline].
Pautrier L-M. Darier J, ed. Tuberculose nodulare dermique á petits nodules. Nouvelle Pratique. Paris: Masson Editeur; 1936.
Victor T, Jordaan HF, Van Niekerk DJ, Louw M, Jordaan A, Van Helden PD. Papulonecrotic tuberculid. Identification of Mycobacterium tuberculosis DNA by polymerase chain reaction. Am J Dermatopathol. Dec 1992;14(6):491-5. [Medline].
Wilson-Jones E, Winkelmann RK. Papulonecrotic tuberculid: a neglected disease in Western countries. J Am Acad Dermatol. May 1986;14(5 Pt 1):815-26. [Medline].
Further Reading
Keywords
papulonecrotic tuberculid, PNT, necrotizing skin papules, tuberculosis hypersensitivity, TB antigens


Overview: Papulonecrotic Tuberculids