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Erythroderma (Generalized Exfoliative Dermatitis) Differential Diagnoses

  • Author: Sanusi H Umar, MD, FAAD; Chief Editor: Dirk M Elston, MD  more...
Updated: Mar 03, 2016
Contributor Information and Disclosures

Sanusi H Umar, MD, FAAD Clinical Instructor of Medicine, Department of Medicine, Division of Dermatology, University of California, Los Angeles, David Geffen School of Medicine

Sanusi H Umar, MD, FAAD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, American Medical Association

Disclosure: Nothing to disclose.


A Paul Kelly, MD Chief, Clinical Professor, Department of Internal Medicine, Division of Dermatology, King/Drew Medical Center, Charles Drew University of Medicine and Science

A Paul Kelly, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, National Medical Association, Pacific Dermatologic Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Rosalie Elenitsas, MD Herman Beerman Professor of Dermatology, University of Pennsylvania School of Medicine; Director, Penn Cutaneous Pathology Services, Department of Dermatology, University of Pennsylvania Health System

Rosalie Elenitsas, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society of Dermatopathology, Pennsylvania Academy of Dermatology

Disclosure: Received royalty from Lippincott Williams Wilkins for textbook editor.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

James W Patterson, MD Professor of Pathology and Dermatology, Director of Dermatopathology, University of Virginia Medical Center

James W Patterson, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, American Society of Dermatopathology, Royal Society of Medicine, Society for Investigative Dermatology, United States and Canadian Academy of Pathology

Disclosure: Nothing to disclose.

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Exfoliative dermatitis diffuse skin involvement.
Exfoliative dermatitis close-up view showing erythema and scaling.
Table. Drugs Implicated in the Causation of Exfoliative Dermatitis
99mTC-sestamibi[8] ACE inhibitorsAllopurinolAminoglutethimideAmiodarone
AmitriptylineAmoxicillinAmpicillinAngiogenetic inhibitors[9] Arsenic
BenactyzineBeta-blockersBeta caroteneBumetanideBupropion
Cephalosporins[10] ChloroquineChlorpromazineChlorpropamideCimetidine
CiprofloxacinCisplatinClofarabine[11] ClofazimineClofibrate
DoxorubicinDoxycyclineEfavirenz[12] EnalaprilEscitalopram[13]
Esomeprazole[14] Ethambutol[15] EtodolacFenofibrate[16] Fenoprofen
FluconazoleFluindione[17] Fluoxetine[18] FluphenazineFlurbiprofen
FurosemideGemfibrozilGliclazide[19] Glipizide[20] Gold
GriseofulvinHydroxychloroquineImatinib[21] ImipramineIndomethacin
Intravenous immunoglobulin[22] Intravesical mitomycin C[23] Iodixanol[24] IsoniazidIsosorbide
KetoconazoleKetoprofenKetorolacLeflunomide[25] Lithium
MeclofenamateMefenamic AcidMeprobamateMethylphenidate
Midodrine[26] MinocyclineMorphine sulfate[27] Nalidixic AcidNaproxen
Nevirapine[28] Nitrazepam[20] NifedipineNitrofurantoinNitroglycerin
NizatidineNorfloxacinOmeprazolePantoprazole[29] Penicillamine
PropranololPyrazinamide[15] PyrazolonesQuinaprilQuinidine
QuinineRetinoidsRifampinSorafenib[30] Streptomycin
Strontium ranelate[31] SulfadoxineSulfamethoxazoleSulfasalazineSulfisoxazole
SulfonamidesSulfonylureasSulindacTerbinafine[32] Tetracycline
TobramycinTocilizumab[33] TrazodoneTrifluoperazineTrimethoprim
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