Pityriasis Rotunda Medication

  • Author: Jaggi Rao, MD, FRCPC; Chief Editor: Dirk M Elston, MD  more...
 
Updated: Jul 15, 2016
 

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

Next

Retinoids

Class Summary

Retinoids decrease the cohesiveness of abnormal hyperproliferative keratinocytes and may reduce the potential for malignant degeneration. They modulate keratinocyte differentiation. Retinoids have been shown to reduce the risk of skin cancer formation in renal transplant patients.

Tretinoin topical (Avita, Retin-A)

 

Tretinoin topical inhibits microcomedo formation and eliminates lesions. It makes keratinocytes in sebaceous follicles less adherent and easier to remove. It is available as 0.025%, 0.05%, and 0.1% creams and 0.01% and 0.025% gels.

Previous
Next

Emollients

Class Summary

Emollients contain colloidal solids and various oils that act as emollients. They are recommended for relief of minor skin irritations and pruritus associated with common dermatoses and dry skin conditions.

Ammonium lactate (Lac-Hydrin, AmLactin) 12% cream or lotion

 

Ammonium lactate relieves itching and aids healing of skin in mild eczemas and dermatoses; itching skin, minor wounds, and minor skin irritations. Lactic acid is an alpha-hydroxy acid with keratolytic properties.

Previous
Next

Keratolytic Agents

Class Summary

Keratolytic Agents cause cornified epithelium to swell, soften, macerate, and then desquamate.

Salicylic acid topical (Salex)

 

By dissolving the intercellular cement substance, salicylic acid topical produces desquamation of the horny layer of skin while not affecting the structure of viable epidermis. Hydrate the skin and enhance the effects of the medication by soaking the affected area in warm water for 5 minutes prior to use. Remove any loose tissue with a brush, washcloth, or emery board and dry thoroughly. Improvement generally occurs in 1-2 weeks. Maximum resolution is expected after 4-6 weeks.

Previous
 
Contributor Information and Disclosures
Author

Jaggi Rao, MD, FRCPC Clinical Professor of Medicine, Division of Dermatology and Cutaneous Sciences, Director of Dermatology Residency Program, University of Alberta Faculty of Medicine and Dentistry

Jaggi Rao, MD, FRCPC is a member of the following medical societies: American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for Laser Medicine and Surgery, Canadian Medical Association, Pacific Dermatologic Association, Royal College of Physicians and Surgeons of Canada, Canadian Medical Protective Association, Canadian Dermatology Association

Disclosure: Nothing to disclose.

Coauthor(s)

Andrew Lin, MD, FRCPC Associate Professor, Department of Internal Medicine, Division of Dermatology, University of Alberta

Andrew Lin, MD, FRCPC is a member of the following medical societies: American Academy of Dermatology, Royal College of Physicians and Surgeons of Canada

Disclosure: Nothing to disclose.

Andrei I Metelitsa, MD, FRCPC Assistant Clinical Professor, Section of Dermatology, University of Calgary Faculty of Medicine, Canada

Andrei I Metelitsa, MD, FRCPC is a member of the following medical societies: American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for Laser Medicine and Surgery, Canadian Medical Protective Association, Canadian Dermatology Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Jeffrey Meffert, MD Associate Clinical Professor of Dermatology, University of Texas School of Medicine at San Antonio

Jeffrey Meffert, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

James W Patterson, MD Professor of Pathology and Dermatology, Director of Dermatopathology, University of Virginia Medical Center

James W Patterson, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, American Society of Dermatopathology, Royal Society of Medicine, Society for Investigative Dermatology, United States and Canadian Academy of Pathology

Disclosure: Nothing to disclose.

References
  1. Waisman M. Pityriasis rotunda. Cutis. 1986 Oct. 38(4):247-8. [Medline].

  2. Pinto GM, Tapadinhas C, Moura C, Afonso A. Pityriasis rotunda. Cutis. 1996 Dec. 58(6):406-8. [Medline].

  3. Grimalt R, Gelmetti C, Brusasco A, Tadini G, Caputo R. Pityriasis rotunda: report of a familial occurrence and review of the literature. J Am Acad Dermatol. 1994 Nov. 31(5 Pt 2):866-71. [Medline].

  4. L'Henaff N, Combemale P. [Pityriasis rotunda. Review of the literature]. Ann Dermatol Venereol. 1993. 120(4):305-9. [Medline].

  5. Mastura U. Uber kreisrunde pityriasis. Jpn Z Derm Urol. 1906. 6:3-4.

  6. Pari T, Pulimood S, George S, Jacob M. Pityriasis rotunda. J Eur Acad Dermatol Venereol. 1998 Jul. 11(1):82-3. [Medline].

  7. Toyama T. Uber eine bisher noch nicht beschriebene dermatose: "pityriasis circinata". Arch Dermatol Syphiligr. 1913. 116:243-58.

  8. Toyama T. Uber eine schuppende, pigmentierte: kreisrunde hautaffektion. Jpn Z Derm Urol. 1906. 6:2.

  9. Weiss RM. Pityriasis rotunda. Arch Dermatol. 1989 Jul. 125(7):1002. [Medline].

  10. Zina AM, Ubertalli S, Bundino S. Pityriasis rotunda. Int J Dermatol. 1986 Jan-Feb. 25(1):56-7. [Medline].

  11. Finch JJ, Olson CL. Hyperpigmented patches on the trunk of a Nigerian woman. Pityriasis rotunda (PR). Arch Dermatol. 2008 Nov. 144(11):1509-14. [Medline].

  12. Mafong EA. Pityriasis rotunda. Dermatol Online J. 2002 Oct. 8(2):15. [Medline].

  13. Porges DY, Scott RA. Pityriasis rotunda with HTLV-1 associated tropical spastic paraparesis. NY. 1992. 184A.

  14. Rubin MG, Mathes B. Pityriasis rotunda: two cases in black Americans. J Am Acad Dermatol. 1986 Jan. 14(1):74-8. [Medline].

  15. Lefkowitz EG, Natow AJ. Pityriasis Rotunda: A Case Report of Familial Disease in an American-Born Black Patient. Case Rep Dermatol. 2016 Jan-Apr. 8 (1):71-4. [Medline].

  16. Aste N, Pau M, Aste N, Biggio P. Pityriasis rotunda: a survey of 42 cases observed in Sardinia, Italy. Dermatology. 1997. 194(1):32-5. [Medline].

  17. Gibbs S. Pityriasis rotunda in Tanzania. Br J Dermatol. 1996 Sep. 135(3):491-2. [Medline].

  18. Gupta S. Pityriasis rotunda mimicking tinea cruris/corporis and erythrasma in an Indian patient. J Dermatol. 2001 Jan. 28(1):50-3. [Medline].

  19. Sarkany I, Hare PJ. Pityriasis rotunda (pityriasis circinata). Br J Dermatol. 1964 May. 76:223-8. [Medline].

  20. el-Hefnawi H, Rasheed A. Pityriasis rotunda. "Pseudo-ichtyose acquise en taches circulaires": report and study of first case in UAR. Arch Dermatol. 1966 Jan. 93(1):84-6. [Medline].

  21. Hasson I, Shah P. Pityriasis rotunda. Indian J Dermatol Venereol Leprol. 2003 Jan-Feb. 69(1):50-1. [Medline].

  22. Segal R, Hodak E, Sandbank M. Pityriasis rotunda in a Caucasian woman from the Mediterranean area. Clin Exp Dermatol. 1989 Jul. 14(4):325-7. [Medline].

  23. Ito M, Tanaka T. Pseudo-ichthyose acquise en taches circulaires. Ann Dermatol Syphiligr. 1960. 87:26-37.

  24. Kahana M, Levy A, Ronnen M, Schewach-Millet M, Stempler D. Pityriasis rotunda in a white patient. Report of the second case and review of the literature. J Am Acad Dermatol. 1986 Aug. 15(2 Pt 2):362-5. [Medline].

  25. Berkowitz I, Hodkinson HJ, Kew MC, DiBisceglie AM. Pityriasis rotunda as a cutaneous marker of hepatocellular carcinoma: a comparison with its prevalence in other diseases. Br J Dermatol. 1989 Apr. 120(4):545-9. [Medline].

  26. DiBisceglie AM, Hodkinson HJ, Berkowitz I, Kew MC. Pityriasis rotunda. A cutaneous marker of hepatocellular carcinoma in South African blacks. Arch Dermatol. 1986 Jul. 122(7):802-4. [Medline].

  27. Ena P, Cerimele D. Pityriasis rotunda in childhood. Pediatr Dermatol. 2002 May-Jun. 19(3):200-3. [Medline].

  28. Combemale P, L'Henaff N, Guennoc B. [Pityriasis rotunda]. Ann Dermatol Venereol. 1993. 120(4):287-8. [Medline].

  29. Swift PJ, Saxe N. Pityriasis rotunda in South Africa--a skin disease caused by undernutrition. Clin Exp Dermatol. 1985 Sep. 10(5):407-12. [Medline].

  30. Lodi A, Betti R, Chiarelli G, Carducci M, Crosti C. Familial pityriasis rotunda. Int J Dermatol. 1990 Sep. 29(7):483-5. [Medline].

  31. Friedmann AC, Ameen M, Swale VJ. Familial pityriasis rotunda in black-skinned patients; a first report. Br J Dermatol. 2007 Jun. 156(6):1365-7. [Medline].

  32. Guberman D, Lichtenstein DA, Gilead L, Vardy DA, Klaus SN. Familial pityriasis rotunda. Acta Derm Venereol. 1997 Mar. 77(2):162. [Medline].

  33. Kurzrock R, Cohen PR. Cutaneous paraneoplastic syndromes in solid tumors. Am J Med. 1995 Dec. 99(6):662-71. [Medline].

  34. Ramos-E-Silva M, Carvalho JC, Carneiro SC. Cutaneous paraneoplasia. Clin Dermatol. 2011 Sep-Oct. 29(5):541-7. [Medline].

  35. Abreu Velez AM, Howard MS. Diagnosis and treatment of cutaneous paraneoplastic disorders. Dermatol Ther. 2010 Nov-Dec. 23(6):662-75. [Medline].

  36. Weiss RM. Pigmented lesions in a patient with pulmonary tuberculosis. Pityriasis rotunda. Arch Dermatol. 1991 Aug. 127(8):1221, 1224. [Medline].

  37. Leibowitz MR, Weiss R, Smith EH. Pityriasis rotunda. A cutaneous sign of malignant disease in two patients. Arch Dermatol. 1983 Jul. 119(7):607-9. [Medline].

  38. Etoh T, Nakagawa H, Ishibashi Y. Pityriasis rotunda associated with multiple myeloma. J Am Acad Dermatol. 1991 Feb. 24(2 Pt 1):303-4. [Medline].

  39. Piga S, Cottoni F, Meloni GF. Pityriasis rotunda and G6PD deficiency. Int J Dermatol. 1992 Oct. 31(10):745. [Medline].

Previous
Next
 
Nearly perfectly round, slightly hyperkeratotic, hyperpigmented, asymptomatic plaque on the trunk.
Classic histology for pityriasis rotunda demonstrating mild hyperkeratosis and a reduced granular layer in the epidermis.
 
Medscape Consult
 
 
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.