Laboratory Studies
Scrapings of pityriasis rotunda skin lesions can be examined using potassium hydroxide mount and sent for fungal culture to rule out tinea corporis. Examination with a Wood light is useful in cases suggestive of extraflexural erythrasma.
Imaging Studies
For pityriasis rotunda, use history and physical examination findings directed toward any underlying systemic diseases to guide further laboratory and imaging studies.
Consider investigations into the possibility of hepatocellular carcinoma in black South African patients with pityriasis rotunda.
Procedures
Skin biopsy is often useful to help exclude other diseases listed in Differentials.
Histologic Findings
Mild hyperkeratosis and a reduced or absent granular layer are found. See the image below.
Classic histology for pityriasis rotunda demonstrating mild hyperkeratosis and a reduced granular layer in the epidermis. Waisman M. Pityriasis rotunda. Cutis. Oct 1986;38(4):247-8. [Medline].
Pinto GM, Tapadinhas C, Moura C, Afonso A. Pityriasis rotunda. Cutis. Dec 1996;58(6):406-8. [Medline].
Grimalt R, Gelmetti C, Brusasco A, Tadini G, Caputo R. Pityriasis rotunda: report of a familial occurrence and review of the literature. J Am Acad Dermatol. Nov 1994;31(5 Pt 2):866-71. [Medline].
L'Henaff N, Combemale P. [Pityriasis rotunda. Review of the literature]. Ann Dermatol Venereol. 1993;120(4):305-9. [Medline].
Mastura U. Uber kreisrunde pityriasis. Jpn Z Derm Urol. 1906;6:3-4.
Pari T, Pulimood S, George S, Jacob M. Pityriasis rotunda. J Eur Acad Dermatol Venereol. Jul 1998;11(1):82-3. [Medline].
Toyama T. Uber eine bisher noch nicht beschriebene dermatose: "pityriasis circinata". Arch Dermatol Syphiligr. 1913;116:243-58.
Toyama T. Uber eine schuppende, pigmentierte: kreisrunde hautaffektion. Jpn Z Derm Urol. 1906;6:2.
Weiss RM. Pityriasis rotunda. Arch Dermatol. Jul 1989;125(7):1002. [Medline].
Zina AM, Ubertalli S, Bundino S. Pityriasis rotunda. Int J Dermatol. Jan-Feb 1986;25(1):56-7. [Medline].
Finch JJ, Olson CL. Hyperpigmented patches on the trunk of a Nigerian woman. Pityriasis rotunda (PR). Arch Dermatol. Nov 2008;144(11):1509-14. [Medline].
Mafong EA. Pityriasis rotunda. Dermatol Online J. Oct 2002;8(2):15. [Medline].
Porges DY, Scott RA. Pityriasis rotunda with HTLV-1 associated tropical spastic paraparesis. NY. 1992;184A.
Rubin MG, Mathes B. Pityriasis rotunda: two cases in black Americans. J Am Acad Dermatol. Jan 1986;14(1):74-8. [Medline].
Aste N, Pau M, Aste N, Biggio P. Pityriasis rotunda: a survey of 42 cases observed in Sardinia, Italy. Dermatology. 1997;194(1):32-5. [Medline].
Gibbs S. Pityriasis rotunda in Tanzania. Br J Dermatol. Sep 1996;135(3):491-2. [Medline].
Gupta S. Pityriasis rotunda mimicking tinea cruris/corporis and erythrasma in an Indian patient. J Dermatol. Jan 2001;28(1):50-3. [Medline].
Sarkany I, Hare PJ. Pityriasis rotunda (pityriasis circinata). Br J Dermatol. May 1964;76:223-8. [Medline].
el-Hefnawi H, Rasheed A. Pityriasis rotunda. "Pseudo-ichtyose acquise en taches circulaires": report and study of first case in UAR. Arch Dermatol. Jan 1966;93(1):84-6. [Medline].
Hasson I, Shah P. Pityriasis rotunda. Indian J Dermatol Venereol Leprol. Jan-Feb 2003;69(1):50-1. [Medline].
Segal R, Hodak E, Sandbank M. Pityriasis rotunda in a Caucasian woman from the Mediterranean area. Clin Exp Dermatol. Jul 1989;14(4):325-7. [Medline].
Berkowitz I, Hodkinson HJ, Kew MC, DiBisceglie AM. Pityriasis rotunda as a cutaneous marker of hepatocellular carcinoma: a comparison with its prevalence in other diseases. Br J Dermatol. Apr 1989;120(4):545-9. [Medline].
DiBisceglie AM, Hodkinson HJ, Berkowitz I, Kew MC. Pityriasis rotunda. A cutaneous marker of hepatocellular carcinoma in South African blacks. Arch Dermatol. Jul 1986;122(7):802-4. [Medline].
Ito M, Tanaka T. Pseudo-ichthyose acquise en taches circulaires. Ann Dermatol Syphiligr. 1960;87:26-37.
Kahana M, Levy A, Ronnen M, Schewach-Millet M, Stempler D. Pityriasis rotunda in a white patient. Report of the second case and review of the literature. J Am Acad Dermatol. Aug 1986;15(2 Pt 2):362-5. [Medline].
Ena P, Cerimele D. Pityriasis rotunda in childhood. Pediatr Dermatol. May-Jun 2002;19(3):200-3. [Medline].
Combemale P, L'Henaff N, Guennoc B. [Pityriasis rotunda]. Ann Dermatol Venereol. 1993;120(4):287-8. [Medline].
Swift PJ, Saxe N. Pityriasis rotunda in South Africa--a skin disease caused by undernutrition. Clin Exp Dermatol. Sep 1985;10(5):407-12. [Medline].
Lodi A, Betti R, Chiarelli G, Carducci M, Crosti C. Familial pityriasis rotunda. Int J Dermatol. Sep 1990;29(7):483-5. [Medline].
Friedmann AC, Ameen M, Swale VJ. Familial pityriasis rotunda in black-skinned patients; a first report. Br J Dermatol. Jun 2007;156(6):1365-7. [Medline].
Guberman D, Lichtenstein DA, Gilead L, Vardy DA, Klaus SN. Familial pityriasis rotunda. Acta Derm Venereol. Mar 1997;77(2):162. [Medline].
Kurzrock R, Cohen PR. Cutaneous paraneoplastic syndromes in solid tumors. Am J Med. Dec 1995;99(6):662-71. [Medline].
Ramos-E-Silva M, Carvalho JC, Carneiro SC. Cutaneous paraneoplasia. Clin Dermatol. Sep-Oct 2011;29(5):541-7. [Medline].
Abreu Velez AM, Howard MS. Diagnosis and treatment of cutaneous paraneoplastic disorders. Dermatol Ther. Nov-Dec 2010;23(6):662-75. [Medline].
Weiss RM. Pigmented lesions in a patient with pulmonary tuberculosis. Pityriasis rotunda. Arch Dermatol. Aug 1991;127(8):1221, 1224. [Medline].
Leibowitz MR, Weiss R, Smith EH. Pityriasis rotunda. A cutaneous sign of malignant disease in two patients. Arch Dermatol. Jul 1983;119(7):607-9. [Medline].
Etoh T, Nakagawa H, Ishibashi Y. Pityriasis rotunda associated with multiple myeloma. J Am Acad Dermatol. Feb 1991;24(2 Pt 1):303-4. [Medline].
Piga S, Cottoni F, Meloni GF. Pityriasis rotunda and G6PD deficiency. Int J Dermatol. Oct 1992;31(10):745. [Medline].
Agostini G, Hoang-Xuan D, Rybojad M, Puissant A. [Toyama's pityriasis rotunda]. Ann Dermatol Venereol. 1988;115(11):1226-7. [Medline].
Alberti A, Conte R, Reggiani M. [Pityriasis rotunda: study of 2 family groups. Preliminary report]. G Ital Dermatol Venereol. Apr 1988;123(4):159-60. [Medline].
Aste N, Biggio P. [Pityriasis rotunda in south-central Sardinia. Preliminary note]. G Ital Dermatol Venereol. Sep-Oct 1986;121(5):331-4. [Medline].
Aste N, Pau M, Aste N, Biggio P. Case report. Pityriasis versicolor mimicking Pityriasis rotunda. Mycoses. Apr 2002;45(3-4):126-8. [Medline].
Desruelles F, Gari-Toussaint M, Lacour JP, Marty P, Le Fichoux Y, Ortonne JP. Tinea versicolor mimicking pityriasis rotunda. Int J Dermatol. Dec 1999;38(12):948-9. [Medline].
Ena P, Siddi GM. Pityriasis versicolor resembling pityriasis rotunda. J Eur Acad Dermatol Venereol. Jan 2002;16(1):85-7. [Medline].
Griffin LJ, Massa MC. Acquired ichthyosis and pityriasis rotunda. Clin Dermatol. Jan-Mar 1993;11(1):27-32. [Medline].
Ikada J, Oki M. Concurrent pityriasis rotunda and acquired ichthyosis with IgG myeloma. Br J Dermatol. Nov 1974;91(5):585-6. [Medline].
Lewis AD. Pityriasis rotunda: a dermatophytosis?. Arch Dermatol. Apr 1987;123(4):426-7. [Medline].

