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Acropustulosis of Infancy: Differential Diagnoses & Workup

Author: Howard Pride, MD, Associate Professor, Departments of Pediatrics and Dermatology, Geisinger Medical Center
Contributor Information and Disclosures

Updated: Sep 22, 2009

Differential Diagnoses

Candidiasis, Cutaneous
Hand-Foot-and-Mouth Disease
Chickenpox
Impetigo
Cutaneous Larva Migrans
Psoriasis, Pustular
Dyshidrotic Eczema
Scabies
Erythema Toxicum Neonatorum
Transient Neonatal Pustular Melanosis
Fire Ant Bites
Vesicular Palmoplantar Eczema

Other Problems to Be Considered

Eosinophilic pustulosis6

Workup

Laboratory Studies

  • No laboratory studies are needed to make the diagnosis of infantile acropustulosis.
  • A complete blood cell count often shows eosinophilia.
  • Cultures and smears help to rule out an infectious etiology.

Histologic Findings

A unilocular, subcorneal, or intraepidermal pustule containing polymorphonuclear neutrophils or eosinophils is characteristic in infantile acropustulosis. Papillary dermal edema and a mild perivascular, mostly lymphocytic, infiltrate in the dermis may be present.5 Direct immunofluorescence results are negative.

More on Acropustulosis of Infancy

Overview: Acropustulosis of Infancy
Differential Diagnoses & Workup: Acropustulosis of Infancy
Treatment & Medication: Acropustulosis of Infancy
Follow-up: Acropustulosis of Infancy
Multimedia: Acropustulosis of Infancy
References

References

  1. Kahn G, Rywlin AM. Acropustulosis of infancy. Arch Dermatol. Jul 1979;115(7):831-3. [Medline].

  2. Humeau S, Bureau B, Litoux P, Stalder JF. Infantile acropustulosis in six immigrant children. Pediatr Dermatol. Sep 1995;12(3):211-4. [Medline].

  3. Prendiville JS. Infantile acropustulosis--how often is it a sequela of scabies?. Pediatr Dermatol. Sep 1995;12(3):275-6. [Medline].

  4. Mancini AJ, Frieden IJ, Paller AS. Infantile acropustulosis revisited: history of scabies and response totopical corticosteroids. Pediatr Dermatol. Sep-Oct 1998;15(5):337-41. [Medline].

  5. Dromy R, Raz A, Metzker A. Infantile acropustulosis. Pediatr Dermatol. Dec 1991;8(4):284-7. [Medline].

  6. Vicente J, Espana A, Idoate M, et al. Are eosinophilic pustular folliculitis of infancy and infantile acropustulosis the same entity?. Br J Dermatol. Nov 1996;135(5):807-9. [Medline].

  7. Truong AL, Esterly NB. Atypical acropustulosis in infancy. Int J Dermatol. Sep 1997;36(9):688-91. [Medline].

  8. Wagner A. Distinguishing vesicular and pustular disorders in the neonate. Curr Opin Pediatr. Aug 1997;9(4):396-405. [Medline].

Further Reading

Keywords

acropustulosis of infancy, infantile acropustulosis, infant acropustulosis

Contributor Information and Disclosures

Author

Howard Pride, MD, Associate Professor, Departments of Pediatrics and Dermatology, Geisinger Medical Center
Howard Pride, MD is a member of the following medical societies: American Academy of Dermatology and Society for Pediatric Dermatology
Disclosure: Nothing to disclose.

Medical Editor

Daniel Mark Siegel, MD, MS, Director, Procedural Dermatology Fellowship Program, Clinical Professor of Dermatology, Department of Dermatology, State University of New York Downstate
Daniel Mark Siegel, MD, MS is a member of the following medical societies: American Academy of Dermatology, American Academy of Facial Plastic and Reconstructive Surgery, American College of Mohs Micrographic Surgery and Cutaneous Oncology, American College of Physician Executives, American Society for Dermatologic Surgery, American Society for Laser Medicine and Surgery, American Society for MOHS Surgery, and International Society for Dermatologic Surgery
Disclosure: Nothing to disclose.

Pharmacy Editor

Michael J Wells, MD, Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center
Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.

Managing Editor

Van Perry, MD, Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas Health Science Center
Van Perry, MD is a member of the following medical societies: American Academy of Dermatology and American Society for Laser Medicine and Surgery
Disclosure: Nothing to disclose.

CME Editor

Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University
Catherine Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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