Acropustulosis of Infancy Medication
- Author: Howard Pride, MD; Chief Editor: Dirk M Elston, MD more...
Medication Summary
High-potency topical steroids (classes 1 and 2) have been used successfully for control of pruritus. Children who are extremely symptomatic may be treated with dapsone.
Topical steroids
Class Summary
These agents provide symptomatic relief of pruritus.
Betamethasone topical (Diprolene, Betatrex)
For inflammatory dermatoses responsive to steroids. Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. Use fluorinated topical steroids with caution in children.
Antibiotics
Class Summary
Diaminodiphenylsulfone antibiotics have been used as anti-inflammatory agents.
Dapsone (Avlosulfon)
Bactericidal and bacteriostatic against mycobacteria; mechanism of action is similar to that of sulfonamides where competitive antagonists of PABA prevent formation of folic acid, inhibiting bacterial growth. Used mainly to treat leprosy and dermatitis herpetiformis. Has antineutrophil and anti-inflammatory properties.
Antipruritics
Class Summary
These agents may relieve associated itching.
Pramoxine topical (Tronothane, Prax)
Blocks nerve conduction and impulses by inhibiting depolarization of neurons. Use 1% lotion or cream.
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