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Dermatologic Manifestations of Gianotti-Crosti Syndrome Follow-up

  • Author: Kara N Shah, MD, PhD; Chief Editor: William D James, MD  more...
 
Updated: Feb 16, 2016
 

Further Outpatient Care

A follow-up visit after 2 months for evaluation of persistent signs or symptoms is advisable. Children with atypical presentations should also be reevaluated after 2-4 weeks to evaluate progression and to confirm the diagnosis.

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Complications

There are no expected complications of Gianotti-Crosti syndrome. Complications may arise from the inciting infection, if present.

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Prognosis

The prognosis is excellent. This syndrome is generally a benign, self-limited condition. The eruption usually starts to resolve after 6-8 weeks.

In the original cases of hepatitis B virus-associated disease, anicteric hepatitis developed in a proportion of patients. Anicteric hepatitis may also be seen in cases associated with other viral illnesses such as EBV.

In extremely rare cases, chronic liver disease has followed the initial phase of infection with hepatitis B virus.

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Patient Education

Discussion with the parents regarding the benign, self-limited course is advisable. If a particular viral or bacterial infection is suspected as the etiology, the course of the associated infection should also be discussed.

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Contributor Information and Disclosures
Author

Kara N Shah, MD, PhD Associate Professor, Departments of Pediatrics and Dermatology, University of Cincinnati College of Medicine; Medical Director, Pediatric Dermatology, Cincinnati Children's Hospital

Kara N Shah, MD, PhD is a member of the following medical societies: American Academy of Dermatology, American Academy of Pediatrics, Society for Pediatric Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Van Perry, MD Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas School of Medicine at San Antonio

Van Perry, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Acknowledgements

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous authors, Albert C Yan, MD, and Paul J Honig, MD, to the development and writing of this article.

References
  1. Taieb A, Plantin P, Du Pasquier P, Guillet G, Maleville J. Gianotti-Crosti syndrome: a study of 26 cases. Br J Dermatol. 1986 Jul. 115(1):49-59. [Medline].

  2. Manoharan S, Muir J, Williamson R. Gianotti-Crosti syndrome in an adult following recent Mycoplasma pneumoniae infection. Australas J Dermatol. 2005 May. 46(2):106-9. [Medline].

  3. Turhan V, Ardic N, Besirbellioglu B, Dogru T. Gianotti-Crosti syndrome associated with HBV infection in an adult. Ir J Med Sci. 2005 Jul-Sep. 174(3):92-4. [Medline].

  4. Gibbs S, Burrows N. Gianotti-Crosti syndrome in two unrelated adults. Clin Exp Dermatol. 2000 Nov. 25(8):594-6. [Medline].

  5. Mempel M, Abeck D, Bye-Hansen T, Ring J. Gianotti-Crosti syndrome in an adult patient following a recently acquired Epstein-Barr virus infection. Acta Derm Venereol. 1996 Nov. 76(6):502-3. [Medline].

  6. Cambiaghi S, Scarabelli G, Pistritto G, Gelmetti C. Gianotti-Crosti syndrome in an adult after influenza virus vaccination. Dermatology. 1995. 191(4):340-1. [Medline].

  7. Ting PT, Barankin B, Dytoc MT. Gianotti-Crosti syndrome in two adult patients. J Cutan Med Surg. 2008 May-Jun. 12(3):121-5. [Medline].

  8. Iorizzo LJ 3rd, Scott G, Tausk FA. Gianotti-Crosti syndrome: a case report in an adult. Cutis. 2012 Apr. 89(4):169-72. [Medline].

  9. Metelitsa AI, Fiorillo L. Recurrent Gianotti-Crosti syndrome. J Am Acad Dermatol. 2011 Oct. 65(4):876-7. [Medline].

  10. Ricci G, Patrizi A, Neri I, Specchia F, Tosti G, Masi M. Gianotti-Crosti syndrome and allergic background. Acta Derm Venereol. 2003. 83(3):202-5. [Medline].

  11. Caputo R, Gelmetti C, Ermacora E, Gianni E, Silvestri A. Gianotti-Crosti syndrome: a retrospective analysis of 308 cases. J Am Acad Dermatol. 1992 Feb. 26(2 Pt 1):207-10. [Medline].

  12. Lacour M, Harms M. Gianotti-Crosti syndrome as a result of vaccination and Epstein-Barr virus infection. Eur J Pediatr. 1995 Aug. 154(8):688-9. [Medline].

  13. Hofmann B, Schuppe HC, Adams O, et al. Gianotti-Crosti syndrome associated with Epstein-Barr virus infection. Pediatr Dermatol. 1997 Jul-Aug. 14(4):273-7. [Medline].

  14. Spear KL, Winkelmann RK. Gianotti-Crosti syndrome. A review of ten cases not associated with hepatitis B. Arch Dermatol. 1984 Jul. 120(7):891-6. [Medline].

  15. Terasaki K, Koura S, Tachikura T, Kanzaki T. Gianotti-Crosti syndrome associated with endogenous reactivation of Epstein-Barr virus. Dermatology. 2003. 207(1):68-71. [Medline].

  16. Draelos ZK, Hansen RC, James WD. Gianotti-Crosti syndrome associated with infections other than hepatitis B. JAMA. 1986 Nov 7. 256(17):2386-8. [Medline].

  17. James WD, Odom RB, Hatch MH. Gianotti-Crosti-like eruption associated with coxsackievirus A-16 infection. J Am Acad Dermatol. 1982 May. 6(5):862-6. [Medline].

  18. Carrascosa JM, Just M, Ribera M, Ferrandiz C. Papular acrodermatitis of childhood related to poxvirus and parvovirus B19 infection. Cutis. 1998 May. 61(5):265-7. [Medline].

  19. Blauvelt A, Turner ML. Gianotti-Crosti syndrome and human immunodeficiency virus infection. Arch Dermatol. 1994 Apr. 130(4):481-3. [Medline].

  20. May J, Pollack R. Giannoti-Crosti syndrome associated with type A influenza. Pediatr Dermatol. 2011 Nov-Dec. 28(6):733-5. [Medline].

  21. Chuh AA, Chan HH, Chiu SS, Ng HY, Peiris JS. A prospective case control study of the association of Gianotti-Crosti syndrome with human herpesvirus 6 and human herpesvirus 7 infections. Pediatr Dermatol. 2002 Nov-Dec. 19(6):492-7. [Medline].

  22. Dauendorffer JN, Dupuy A. Gianotti-Crosti syndrome associated with herpes simplex virus type 1 gingivostomatitis. J Am Acad Dermatol. 2011 Feb. 64(2):450-1. [Medline].

  23. Di Lernia V. Gianotti-Crosti syndrome related to rotavirus infection. Pediatr Dermatol. 1998 Nov-Dec. 15(6):485-6. [Medline].

  24. Khan I, Gleeson J, McKenna D. Gianotti-Crosti syndrome following meningococcal septicaemia. Ir Med J. 2007 Feb. 100(2):373. [Medline].

  25. Monastirli A, Varvarigou A, Pasmatzi E, Badavanis G, Georgiou S, Mantagos S, et al. Gianotti-Crosti syndrome after hepatitis A vaccination. Acta Derm Venereol. 2007. 87(2):174-5. [Medline].

  26. Kolivras A, André J. Gianotti-Crosti syndrome following hepatitis A vaccination. Pediatr Dermatol. 2008 Nov-Dec. 25(6):650. [Medline].

  27. Andiran N, Sentürk GB, Bükülmez G. Combined vaccination by measles and hepatitis B vaccines: a new cause of Gianotti-Crosti syndrome. Dermatology. 2002. 204(1):75-6. [Medline].

  28. Karakas M, Durdu M, Tuncer I, Cevlik F. Gianotti-Crosti syndrome in a child following hepatitis B virus vaccination. J Dermatol. 2007 Feb. 34(2):117-20. [Medline].

  29. Tay YK. Gianotti-Crosti syndrome following immunization. Pediatr Dermatol. 2001 May-Jun. 18(3):262. [Medline].

  30. Velangi SS, Tidman MJ. Gianotti-Crosti syndrome after measles, mumps and rubella vaccination. Br J Dermatol. 1998 Dec. 139(6):1122-3. [Medline].

  31. Lam JM. Atypical Gianotti-Crosti syndrome following administration of the AS03-adjuvanted H1N1 vaccine. J Am Acad Dermatol. 2011 Oct. 65(4):e127-8. [Medline].

  32. Kwon NH, Kim JE, Cho BK, Park HJ. Gianotti-Crosti Syndrome Following Novel Influenza A (H1N1) Vaccination. Ann Dermatol. 2011 Nov. 23(4):554-5. [Medline]. [Full Text].

  33. Kroeskop A, Lewis AB, Barril FA, Baribault KE. Gianotti-Crosti syndrome after H1N1-influenza vaccine. Pediatr Dermatol. 2011 Sep-Oct. 28(5):595-6. [Medline].

  34. Erkek E, Senturk GB, Ozkaya O, Bükülmez G. Gianotti-Crosti syndrome preceded by oral polio vaccine and followed by varicella infection. Pediatr Dermatol. 2001 Nov-Dec. 18(6):516-8. [Medline].

  35. Kang NG, Oh CW. Gianotti-Crosti syndrome following Japanese encephalitis vaccination. J Korean Med Sci. 2003 Jun. 18(3):459-61. [Medline].

  36. Retrouvey M, Koch LH, Williams JV. Gianotti-Crosti syndrome following childhood vaccinations. Pediatr Dermatol. 2013 Jan-Feb. 30(1):137-8. [Medline].

  37. Baldari U, Monti A, Righini MG. An epidemic of infantile papular acrodermatitis (Gianotti-Crosti syndrome) due to Epstein-Barr virus. Dermatology. 1994. 188(3):203-4. [Medline].

  38. Chuh A, Zawar V, Sciallis GF, Lee A. The diagnostic criteria of pityriasis rosea and Gianotti-Crosti syndrome - a protocol to establish diagnostic criteria of skin diseases. J R Coll Physicians Edinb. 2015. 45 (3):218-25. [Medline].

  39. Chuh AA. Diagnostic criteria for Gianotti-Crosti syndrome: a prospective case-control study for validity assessment. Cutis. 2001 Sep. 68 (3):207-13. [Medline].

  40. Zawar V, Chuh A. Efficacy of ribavirin in a case of long lasting and disabling Gianotti-Crosti syndrome. J Dermatol Case Rep. 2008 Dec 27. 2(4):63-6. [Medline]. [Full Text].

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Characteristic erythematous papules of Gianotti-Crosti syndrome appear on the face of this child. The child does not have a toxic appearance.
Characteristic erythematous papules of Gianotti-Crosti syndrome can be seen on the extremities, as is the case in this young child.
A 9-year-old girl who recently returned from a trip to Europe with her family. She developed a low-grade fever, malaise, and some lymphadenopathy. An eruption limited to her face, arms, legs, and buttocks was noted.
A mildly pruritic eruption characterized by erythematous papules localized to the face, arms, legs, and buttocks.
 
 
 
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