Topical keratolytics, emollients, and hydrating agents are used to reduce scaling associated with X-linked ichthyosis  Topical retinoids may be beneficial. In a small study, the topical receptor-selective retinoid tazarotene was efficacious.
Patients often choose to use no therapy, although appearance-conscious adolescents and young adults may be eager and willing to treat themselves.
In cases with cryptorchidism, consider surgical intervention if spontaneous descent has not occurred by age 1 year.
An ophthalmologist may detect corneal opacities. An obstetrician should be involved for higher risk delivery in future pregnancies.
Address the risk for testicular carcinoma by monitoring X-linked ichthyosis (XLI) patients with periodic physical examinations.
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