eMedicine Specialties > Dermatology > Pediatric Diseases

Juvenile Xanthogranuloma (Nevoxanthoendothelioma): Multimedia

Author: Caroline DS Piggott, MD, Resident, Department of Medicine, Division of Dermatology, University of California, San Diego
Coauthor(s): Michael L Smith, MD, Associate Professor of Medicine (Dermatology) and Pediatrics, Vanderbilt University School of Medicine; Consulting Staff, Vanderbilt University Hospital; Hunter H Sams, MD, Consulting Staff, Denver Dermatology Consultants, PC
Contributor Information and Disclosures

Updated: Oct 23, 2009

Multimedia

Smooth, domed, yellow-brown, 5-mm papule on right...Media file 1: Smooth, domed, yellow-brown, 5-mm papule on right arm of a 6-month-old boy.
Smooth, domed, yellow-brown, 5-mm papule on right...

Smooth, domed, yellow-brown, 5-mm papule on right arm of a 6-month-old boy.

More on Juvenile Xanthogranuloma (Nevoxanthoendothelioma)

Overview: Juvenile Xanthogranuloma (Nevoxanthoendothelioma)
Differential Diagnoses & Workup: Juvenile Xanthogranuloma (Nevoxanthoendothelioma)
Treatment & Medication: Juvenile Xanthogranuloma (Nevoxanthoendothelioma)
Follow-up: Juvenile Xanthogranuloma (Nevoxanthoendothelioma)
Multimedia: Juvenile Xanthogranuloma (Nevoxanthoendothelioma)
References

References

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  4. Imiela A, Carpentier O, Segard-Drouard M, Martin de Lassalle E, Piette F. Juvenile xanthogranuloma: a congenital giant form leading to a wide atrophic sequela. Pediatr Dermatol. Mar-Apr 2004;21(2):121-3. [Medline].

  5. Chang MW, Frieden IJ, Good W. The risk intraocular juvenile xanthogranuloma: survey of current practices and assessment of risk. J Am Acad Dermatol. Mar 1996;34(3):445-9. [Medline].

  6. Chantranuwat C. Systemic form of juvenile xanthogranuloma: report of a case with liver and bone marrow involvement. Pediatr Dev Pathol. Nov-Dec 2004;7(6):646-8. [Medline].

  7. Flach DB, Winkelmann RK. Juvenile xanthogranuloma with central nervous system lesions. J Am Acad Dermatol. Mar 1986;14(3):405-11. [Medline].

  8. Cambiaghi S, Restano L, Caputo R. Juvenile xanthogranuloma associated with neurofibromatosis 1: 14 patients without evidence of hematologic malignancies. Pediatr Dermatol. Mar-Apr 2004;21(2):97-101. [Medline].

  9. Newell GB, Stone OJ, Mullins JF. Juvenile xanthogranuloma and neurofibromatosis. Arch Dermatol. Feb 1973;107(2):262. [Medline].

  10. Shin HT, Harris MB, Orlow SJ. Juvenile myelomonocytic leukemia presenting with features of hemophagocytic lymphohistiocytosis in association with neurofibromatosis and juvenile xanthogranulomas. J Pediatr Hematol Oncol. Sep 2004;26(9):591-5. [Medline].

  11. Zvulunov A, Barak Y, Metzker A. Juvenile xanthogranuloma, neurofibromatosis, and juvenile chronic myelogenous leukemia. World statistical analysis. Arch Dermatol. Aug 1995;131(8):904-8. [Medline].

  12. Raygada M, Arthur DC, Wayne AS, Rennert OM, Toretsky JA, Stratakis CA. Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemia. Pediatr Blood Cancer. Sep 25 2009;[Medline].

  13. Cooper PH, Frierson HF, Kayne AL, Sabio H. Association of juvenile xanthogranuloma with juvenile myeloid leukemia. Arch Dermatol. Mar 1984;120(3):371-5. [Medline].

  14. Rodriguez-Jurado R, Duran-McKinster C, Ruiz-Maldonado R. Benign cephalic histiocytosis progressing into juvenile xanthogranuloma: a non-Langerhans cell histiocytosis transforming under the influence of a virus?. Am J Dermatopathol. Feb 2000;22(1):70-4. [Medline].

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  17. Unuvar E, Devecioglu O, Akcay A, et al. Successful therapy of systemic xanthogranuloma in a child. J Pediatr Hematol Oncol. Jun 2007;29(6):425-7. [Medline].

  18. Burgdorf WH, Zelger B. JXG, NF1, and JMML: alphabet soup or a clinical issue?. Pediatr Dermatol. Mar-Apr 2004;21(2):174-6. [Medline].

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  20. Hu WK, Gilliam AC, Wiersma SR, Dahms BB. Fatal congenital systemic juvenile xanthogranuloma with liver failure. Pediatr Dev Pathol. Jan-Feb 2004;7(1):71-6. [Medline].

  21. Caputo R, Grimalt R, Gelmetti C, Cottoni F. Unusual aspects of juvenile xanthogranuloma. J Am Acad Dermatol. Nov 1993;29(5 Pt 2):868-70. [Medline].

  22. Cohen BA, Hood A. Xanthogranuloma: report on clinical and histologic findings in 64 patients. Pediatr Dermatol. Dec 1989;6(4):262-6. [Medline].

  23. Dehner LP. Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol. May 2003;27(5):579-93. [Medline].

  24. Dehner LP. Reawakening to the existence of juvenile xanthogranuloma. Am J Surg Pathol. Jan 2005;29(1):119-20. [Medline].

  25. Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB. Juvenile xanthogranuloma. J Am Acad Dermatol. Mar 1997;36(3 Pt 1):355-67; quiz 368-9. [Medline].

  26. Iyengar V, Golomb CA, Schachner L. Neurilemmomatosis, NF2, and juvenile xanthogranuloma. J Am Acad Dermatol. Nov 1998;39(5 Pt 2):831-4. [Medline].

  27. Janssen D, Harms D. Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry. Am J Surg Pathol. Jan 2005;29(1):21-8. [Medline].

  28. Ringel E, Moschella S. Primary histiocytic dermatoses. Arch Dermatol. Dec 1985;121(12):1531-41. [Medline].

  29. Roper SS, Spraker MK. Cutaneous histiocytosis syndromes. Pediatr Dermatol. Nov 1985;3(1):19-30. [Medline].

  30. Weitzman S, Jaffe R. Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses. Pediatr Blood Cancer. Sep 2005;45(3):256-64. [Medline].

  31. Zimmerman LE. Ocular lesions of juvenile xanthogranuloma. Nevoxanthoedothelioma. Am J Ophthalmol. Dec 1965;60(6):1011-35. [Medline].

Further Reading

Keywords

juvenile xanthogranulomas, nevoxanthoendothelioma, xanthoma multiplex, juvenile xanthoma, multiple xanthoma in infancy, congenital xanthoma tuberosum, xanthoma naviforme, juvenile giant cell granuloma

Contributor Information and Disclosures

Author

Caroline DS Piggott, MD, Resident, Department of Medicine, Division of Dermatology, University of California, San Diego
Disclosure: Nothing to disclose.

Coauthor(s)

Michael L Smith, MD, Associate Professor of Medicine (Dermatology) and Pediatrics, Vanderbilt University School of Medicine; Consulting Staff, Vanderbilt University Hospital
Michael L Smith, MD is a member of the following medical societies: American Academy of Dermatology, American Academy of Pediatrics, and Society for Pediatric Dermatology
Disclosure: Nothing to disclose.

Hunter H Sams, MD, Consulting Staff, Denver Dermatology Consultants, PC
Hunter H Sams, MD is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Micrographic Surgery and Cutaneous Oncology, and American Society for Dermatologic Surgery
Disclosure: Nothing to disclose.

Medical Editor

Jean Paul Ortonne, MD, Chair, Department of Dermatology, Professor, Hospital L'Archet, Nice University, France
Jean Paul Ortonne, MD is a member of the following medical societies: American Academy of Dermatology and American Dermatological Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Richard P Vinson, MD, Assistant Clinical Professor, Department of Dermatology, Texas Tech University School of Medicine; Consulting Staff, Mountain View Dermatology, PA
Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association
Disclosure: Nothing to disclose.

Managing Editor

Jeffrey Meffert, MD, Assistant Clinical Professor of Dermatology, University of Texas Health Science Center-San Antonio
Jeffrey Meffert, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Association of Military Dermatologists, and Texas Dermatological Society
Disclosure: Nothing to disclose.

CME Editor

Joel M Gelfand, MD, MSCE, Medical Director, Clinical Studies Unit, Assistant Professor, Department of Dermatology, Associate Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania
Joel M Gelfand, MD, MSCE is a member of the following medical societies: Society for Investigative Dermatology
Disclosure: AMGEN Consulting fee Consulting; AMGEN Grant/research funds None; Genentech Consulting fee Consulting; Centocor Consulting fee Consulting; Centocor Grant/research funds None; Covance Consulting fee Consulting; Shire  Consulting

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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