Dermatologic Manifestations of Juvenile Xanthogranuloma Medication

  • Author: Caroline DS Piggott, MD; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jan 24, 2012
 

Medication Summary

Systemic steroids may be used for problematic visceral juvenile xanthogranulomas (JXGs).[21]

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Corticosteroids

Class Summary

Corticosteroids function to shrink the size of visceral nodules. These agents have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli.

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Prednisone (Deltasone, Meticorten, Orasone)

 

DOC for visceral lesions. May decrease inflammation by reversing increased capillary permeability and suppressing PMN activity.

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Contributor Information and Disclosures
Author

Caroline DS Piggott, MD  Resident, Department of Medicine, Division of Dermatology, University of California, San Diego

Disclosure: Nothing to disclose.

Coauthor(s)

Michael L Smith, MD  Associate Professor of Medicine (Dermatology) and Pediatrics, Vanderbilt University School of Medicine; Consulting Staff, Vanderbilt University Hospital

Michael L Smith, MD is a member of the following medical societies: American Academy of Dermatology, American Academy of Pediatrics, and Society for Pediatric Dermatology

Disclosure: Nothing to disclose.

Hunter H Sams, MD  Consulting Staff, Denver Dermatology Consultants, PC

Hunter H Sams, MD is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Micrographic Surgery and Cutaneous Oncology, and American Society for Dermatologic Surgery

Disclosure: Nothing to disclose.

Specialty Editor Board

Jean Paul Ortonne, MD  Chair, Department of Dermatology, Professor, Hospital L'Archet, Nice University, France

Jean Paul Ortonne, MD is a member of the following medical societies: American Academy of Dermatology and American Dermatological Association

Disclosure: Nothing to disclose.

Richard P Vinson, MD  Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association

Disclosure: Nothing to disclose.

Jeffrey Meffert, MD  Assistant Clinical Professor of Dermatology, University of Texas School of Medicine at San Antonio

Jeffrey Meffert, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Association of Military Dermatologists, and Texas Dermatological Society

Disclosure: Nothing to disclose.

Joel M Gelfand, MD, MSCE  Medical Director, Clinical Studies Unit, Assistant Professor, Department of Dermatology, Associate Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania

Joel M Gelfand, MD, MSCE is a member of the following medical societies: Society for Investigative Dermatology

Disclosure: AMGEN Consulting fee Consulting; AMGEN Grant/research funds Investigator; Genentech Grant/research funds investigator; Centocor Consulting fee Consulting; Abbott Grant/research funds investigator; Abbott Consulting fee Consulting; Novartis investigator; Pfizer Grant/research funds investigator; Celgene Consulting fee DMC Chair; NIAMS and NHLBI Grant/research funds investigator

Chief Editor

Dirk M Elston, MD  Director, Ackerman Academy of Dermatopathology, New York

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

The authors and editors of eMedicine gratefully acknowledge the contributions of previous Chief Editor, William D. James, MD, to the development and writing of this article.

References

  1. Kraus MD, Haley JC, Ruiz R, Essary L, Moran CA, Fletcher CD. "Juvenile" xanthogranuloma: an immunophenotypic study with a reappraisal of histogenesis. Am J Dermatopathol. Apr 2001;23(2):104-11. [Medline].

  2. Mancini AJ, Prieto VG, Smoller BR. Role of cellular proliferation and apoptosis in the growth of xanthogranulomas. Am J Dermatopathol. Feb 1998;20(1):17-21. [Medline].

  3. Park YW, Koh EJ, Choi HY. Rapid-growing juvenile xanthogranuloma on the scalp in 18-month-old girl. J Korean Neurosurg Soc. Sep 2011;50(3):271-3. [Medline]. [Full Text].

  4. Campbell L, McTigue MK, Esterly NB, Rosenbaum M. Giant juvenile xanthogranuloma. Arch Dermatol. Nov 1988;124(11):1723-4. [Medline].

  5. Imiela A, Carpentier O, Segard-Drouard M, Martin de Lassalle E, Piette F. Juvenile xanthogranuloma: a congenital giant form leading to a wide atrophic sequela. Pediatr Dermatol. Mar-Apr 2004;21(2):121-3. [Medline].

  6. Chang MW, Frieden IJ, Good W. The risk intraocular juvenile xanthogranuloma: survey of current practices and assessment of risk. J Am Acad Dermatol. Mar 1996;34(3):445-9. [Medline].

  7. Longmuir S, Dumitrescu A, Kwon Y, Boldt HC, Hong S. Juvenile xanthogranulomatosis with bilateral and multifocal ocular lesions of the iris, cornealscleral limbus, and choroid. J AAPOS. Dec 2011;15(6):598-600. [Medline].

  8. Chantranuwat C. Systemic form of juvenile xanthogranuloma: report of a case with liver and bone marrow involvement. Pediatr Dev Pathol. Nov-Dec 2004;7(6):646-8. [Medline].

  9. Maly E, Przyborska M, Rybczynska A, Konatkowska B, Nowak J, Januszkiewicz D. Juvenile Xanthogranuloma With Clonal Proliferation in the Bone Marrow. J Pediatr Hematol Oncol. Dec 31 2011;[Medline].

  10. Flach DB, Winkelmann RK. Juvenile xanthogranuloma with central nervous system lesions. J Am Acad Dermatol. Mar 1986;14(3):405-11. [Medline].

  11. Cambiaghi S, Restano L, Caputo R. Juvenile xanthogranuloma associated with neurofibromatosis 1: 14 patients without evidence of hematologic malignancies. Pediatr Dermatol. Mar-Apr 2004;21(2):97-101. [Medline].

  12. Newell GB, Stone OJ, Mullins JF. Juvenile xanthogranuloma and neurofibromatosis. Arch Dermatol. Feb 1973;107(2):262. [Medline].

  13. Shin HT, Harris MB, Orlow SJ. Juvenile myelomonocytic leukemia presenting with features of hemophagocytic lymphohistiocytosis in association with neurofibromatosis and juvenile xanthogranulomas. J Pediatr Hematol Oncol. Sep 2004;26(9):591-5. [Medline].

  14. Zvulunov A, Barak Y, Metzker A. Juvenile xanthogranuloma, neurofibromatosis, and juvenile chronic myelogenous leukemia. World statistical analysis. Arch Dermatol. Aug 1995;131(8):904-8. [Medline].

  15. Raygada M, Arthur DC, Wayne AS, Rennert OM, Toretsky JA, Stratakis CA. Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemia. Pediatr Blood Cancer. Sep 25 2009;[Medline].

  16. Cooper PH, Frierson HF, Kayne AL, Sabio H. Association of juvenile xanthogranuloma with juvenile myeloid leukemia. Arch Dermatol. Mar 1984;120(3):371-5. [Medline].

  17. Rodriguez-Jurado R, Duran-McKinster C, Ruiz-Maldonado R. Benign cephalic histiocytosis progressing into juvenile xanthogranuloma: a non-Langerhans cell histiocytosis transforming under the influence of a virus?. Am J Dermatopathol. Feb 2000;22(1):70-4. [Medline].

  18. Janney CG, Hurt MA, Santa Cruz DJ. Deep juvenile xanthogranuloma. Subcutaneous and intramuscular forms. Am J Surg Pathol. Feb 1991;15(2):150-9. [Medline].

  19. Fassina A, Olivotto A, Cappellesso R, Vendraminelli R, Fassan M. Fine-needle cytology of cutaneous juvenile xanthogranuloma and langerhans cell histiocytosis. Cancer Cytopathol. Apr 25 2011;119(2):134-40. [Medline].

  20. Haughton AM, Horii KA, Shao L, Daniel J, Nopper AJ. Disseminated juvenile xanthogranulomatosis in a newborn resulting in liver transplantation. J Am Acad Dermatol. Feb 2008;58(2 Suppl):S12-5. [Medline].

  21. Unuvar E, Devecioglu O, Akcay A, et al. Successful therapy of systemic xanthogranuloma in a child. J Pediatr Hematol Oncol. Jun 2007;29(6):425-7. [Medline].

  22. Burgdorf WH, Zelger B. JXG, NF1, and JMML: alphabet soup or a clinical issue?. Pediatr Dermatol. Mar-Apr 2004;21(2):174-6. [Medline].

  23. Vendal Z, Walton D, Chen T. Glaucoma in juvenile xanthogranuloma. Semin Ophthalmol. Jul-Sep 2006;21(3):191-4. [Medline].

  24. Hu WK, Gilliam AC, Wiersma SR, Dahms BB. Fatal congenital systemic juvenile xanthogranuloma with liver failure. Pediatr Dev Pathol. Jan-Feb 2004;7(1):71-6. [Medline].

  25. Caputo R, Grimalt R, Gelmetti C, Cottoni F. Unusual aspects of juvenile xanthogranuloma. J Am Acad Dermatol. Nov 1993;29(5 Pt 2):868-70. [Medline].

  26. Cohen BA, Hood A. Xanthogranuloma: report on clinical and histologic findings in 64 patients. Pediatr Dermatol. Dec 1989;6(4):262-6. [Medline].

  27. Dehner LP. Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol. May 2003;27(5):579-93. [Medline].

  28. Dehner LP. Reawakening to the existence of juvenile xanthogranuloma. Am J Surg Pathol. Jan 2005;29(1):119-20. [Medline].

  29. Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB. Juvenile xanthogranuloma. J Am Acad Dermatol. Mar 1997;36(3 Pt 1):355-67; quiz 368-9. [Medline].

  30. Iyengar V, Golomb CA, Schachner L. Neurilemmomatosis, NF2, and juvenile xanthogranuloma. J Am Acad Dermatol. Nov 1998;39(5 Pt 2):831-4. [Medline].

  31. Janssen D, Harms D. Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry. Am J Surg Pathol. Jan 2005;29(1):21-8. [Medline].

  32. Ringel E, Moschella S. Primary histiocytic dermatoses. Arch Dermatol. Dec 1985;121(12):1531-41. [Medline].

  33. Roper SS, Spraker MK. Cutaneous histiocytosis syndromes. Pediatr Dermatol. Nov 1985;3(1):19-30. [Medline].

  34. Weitzman S, Jaffe R. Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses. Pediatr Blood Cancer. Sep 2005;45(3):256-64. [Medline].

  35. Zimmerman LE. Ocular lesions of juvenile xanthogranuloma. Nevoxanthoedothelioma. Am J Ophthalmol. Dec 1965;60(6):1011-35. [Medline].

 
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