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Kawasaki Disease: Multimedia

Author: Elizabeth Kline Satter, MD, MPH, Staff Dermatologist and Head of Dermatopathology for Residency Program, Department of Dermatology, Naval Medical Center, San Diego
Contributor Information and Disclosures

Updated: May 8, 2008

Multimedia

Clinical manifestations and time course of Kawasa...Media file 1: Clinical manifestations and time course of Kawasaki disease. Courtesy of Paul R. Ogershok, MD.
Clinical manifestations and time course of Kawasa...

Clinical manifestations and time course of Kawasaki disease. Courtesy of Paul R. Ogershok, MD.

Morbilliform eruption in Kawasaki disease. Courte...Media file 2: Morbilliform eruption in Kawasaki disease. Courtesy of Noah S. Scheinfeld, MD, JD.
Morbilliform eruption in Kawasaki disease. Courte...

Morbilliform eruption in Kawasaki disease. Courtesy of Noah S. Scheinfeld, MD, JD.

Desquamation in a patient with mucocutaneous lymp...Media file 3: Desquamation in a patient with mucocutaneous lymph node syndrome (Kawasaki disease). Courtesy of Chemene Y. Quinn, MD.
Desquamation in a patient with mucocutaneous lymp...

Desquamation in a patient with mucocutaneous lymph node syndrome (Kawasaki disease). Courtesy of Chemene Y. Quinn, MD.

Acral desquamation during the subacute phase of t...Media file 4: Acral desquamation during the subacute phase of the illness. Courtesy of Noah S. Scheinfeld, MD, JD.
Acral desquamation during the subacute phase of t...

Acral desquamation during the subacute phase of the illness. Courtesy of Noah S. Scheinfeld, MD, JD.

Oral manifestations of Kawasaki disease: red lips...Media file 5: Oral manifestations of Kawasaki disease: red lips and strawberry tongue. Courtesy of Paul R. Ogershok, MD.
Oral manifestations of Kawasaki disease: red lips...

Oral manifestations of Kawasaki disease: red lips and strawberry tongue. Courtesy of Paul R. Ogershok, MD.

Bulbar conjunctiva congestion in a patient with m...Media file 6: Bulbar conjunctiva congestion in a patient with mucocutaneous lymph node syndrome (Kawasaki disease). Courtesy of Chemene Y. Quinn, MD.
Bulbar conjunctiva congestion in a patient with m...

Bulbar conjunctiva congestion in a patient with mucocutaneous lymph node syndrome (Kawasaki disease). Courtesy of Chemene Y. Quinn, MD.

More on Kawasaki Disease

Overview: Kawasaki Disease
Differential Diagnoses & Workup: Kawasaki Disease
Treatment & Medication: Kawasaki Disease
Follow-up: Kawasaki Disease
Multimedia: Kawasaki Disease
References

References

  1. Kawasaki T. [Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children]. Arerugi. Mar 1967;16(3):178-222. [Medline].

  2. Onouchi Y, Gunji T, Burns JC, Shimizu C, Newburger JW, Yashiro M, et al. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet. Jan 2008;40(1):35-42. [Medline].

  3. Kato S, Kimura M, Tsuji K, Kusakawa S, Asai T, Juji T, et al. HLA antigens in Kawasaki disease. Pediatrics. Feb 1978;61(2):252-5. [Medline].

  4. Matsuda I, Hattori S, Nagata N, Fruse A, Nambu H. HLA antigens in mucocutaneous lymph node syndrome. Am J Dis Child. Dec 1977;131(12):1417-8. [Medline].

  5. Burns JC, Shimizu C, Shike H, Newburger JW, Sundel RP, Baker AL, et al. Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease. Genes Immun. Aug 2005;6(5):438-44. [Medline].

  6. Lee TJ, Chun JK, Yeon SI, Shin JS, Kim DS. Increased serum levels of macrophage migration inhibitory factor in patients with Kawasaki disease. Scand J Rheumatol. May-Jun 2007;36(3):222-5. [Medline].

  7. Leung DY, Schlievert PM, Meissner HC. The immunopathogenesis and management of Kawasaki syndrome. Arthritis Rheum. Sep 1998;41(9):1538-47. [Medline].

  8. Pietra BA, De Inocencio J, Giannini EH, Hirsch R. TCR V beta family repertoire and T cell activation markers in Kawasaki disease. J Immunol. Aug 15 1994;153(4):1881-8. [Medline].

  9. Wang CL, Wu YT, Liu CA, Kuo HC, Yang KD. Kawasaki disease: infection, immunity and genetics. Pediatr Infect Dis J. Nov 2005;24(11):998-1004. [Medline].

  10. Huang GY, Ma XJ, Huang M, Chen SB, Huang MR, Gui YH, et al. Epidemiologic pictures of Kawasaki disease in Shanghai from 1998 through 2002. J Epidemiol. Jan 2006;16(1):9-14. [Medline].

  11. Mason WH, Takahashi M, Schneider T. Recurrence of Kawasaki disease in a large urban cohort in the United States. In: Takahashi M, Taubert K, eds. Proceedings of the Fourth International Symposium on Kawasaki Disease. Dallas, Tex: American Heart Association; 1993:21-6.

  12. Wolff AE, Hansen KE, Zakowski L. Acute Kawasaki disease: not just for kids. J Gen Intern Med. May 2007;22(5):681-4. [Medline].

  13. Han RK, Sinclair B, Newman A, Silverman ED, Taylor GW, Walsh P, et al. Recognition and management of Kawasaki disease. CMAJ. Mar 21 2000;162(6):807-12. [Medline].

  14. Gedalia A. Kawasaki disease: 40 years after the original report. Curr Rheumatol Rep. Aug 2007;9(4):336-41. [Medline].

  15. Satou GM, Giamelli J, Gewitz MH. Kawasaki disease: diagnosis, management, and long-term implications. Cardiol Rev. Jul-Aug 2007;15(4):163-9. [Medline].

  16. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics. Dec 2004;114(6):1708-33. [Medline].

  17. Melish ME, Hicks RV. Kawasaki syndrome: clinical features. Pathophysiology, etiology and therapy. J Rheumatol Suppl. Sep 1990;24:2-10. [Medline].

  18. Yanagawa H, Nakamura Y, Yashiro M, Ojima T, Tanihara S, Oki I, et al. Results of the nationwide epidemiologic survey of Kawasaki disease in 1995 and 1996 in Japan. Pediatrics. Dec 1998;102(6):E65. [Medline].

  19. Yanagawa H, Yashiro M, Nakamura Y, Kawasaki T, Kato H. Epidemiologic pictures of Kawasaki disease in Japan: from the nationwide incidence survey in 1991 and 1992. Pediatrics. Apr 1995;95(4):475-9. [Medline].

  20. Leung DY, Meissner HC, Fulton DR, Murray DL, Kotzin BL, Schlievert PM. Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome. Lancet. Dec 4 1993;342(8884):1385-8. [Medline].

  21. Belay ED, Maddox RA, Holman RC, Curns AT, Ballah K, Schonberger LB. Kawasaki syndrome and risk factors for coronary artery abnormalities: United States, 1994-2003. Pediatr Infect Dis J. Mar 2006;25(3):245-9. [Medline].

  22. Wood L, Tulloh R. Kawasaki disease: diagnosis, management and cardiac sequelae. Expert Rev Cardiovasc Ther. May 2007;5(3):553-61. [Medline].

  23. Newburger JW, Takahashi M, Burns JC, Beiser AS, Chung KJ, Duffy CE, et al. The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med. Aug 7 1986;315(6):341-7. [Medline].

  24. Uehara R, Yashiro M, Oki I, Nakamura Y, Yanagawa H. Re-treatment regimens for acute stage of Kawasaki disease patients who failed to respond to initial intravenous immunoglobulin therapy: analysis from the 17th nationwide survey. Pediatr Int. Aug 2007;49(4):427-30. [Medline].

  25. Abe J, Kotzin BL, Jujo K, Melish ME, Glode MP, Kohsaka T, et al. Selective expansion of T cells expressing T-cell receptor variable regions V beta 2 and V beta 8 in Kawasaki disease. Proc Natl Acad Sci U S A. May 1 1992;89(9):4066-70. [Medline].

  26. Rowley AH, Shulman ST. Kawasaki syndrome. Pediatr Clin North Am. Apr 1999;46(2):313-29. [Medline].

Further Reading

Keywords

mucocutaneous lymph node syndrome, Kawasaki's syndrome, Kawasaki's disease, Kawasaki syndrome, KD, infantile polyarteritis nodosa, IPAN, infantile periarteritis nodosa, medium-sized vessel vasculitis, medium vessel vasculitis, vasculitis of medium vessels, periarteritis nodosa

Contributor Information and Disclosures

Author

Elizabeth Kline Satter, MD, MPH, Staff Dermatologist and Head of Dermatopathology for Residency Program, Department of Dermatology, Naval Medical Center, San Diego
Elizabeth Kline Satter, MD, MPH is a member of the following medical societies: Alpha Omega Alpha and American Medical Women's Association
Disclosure: Nothing to disclose.

Medical Editor

Jean Paul Ortonne, MD, Chair, Department of Dermatology, Professor, Hospital L'Archet, Nice University, France
Jean Paul Ortonne, MD is a member of the following medical societies: American Academy of Dermatology and American Dermatological Association
Disclosure: Nothing to disclose.

Pharmacy Editor

Richard P Vinson, MD, Assistant Clinical Professor, Department of Dermatology, Texas Tech University School of Medicine; Consulting Staff, Mountain View Dermatology, PA
Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association
Disclosure: Nothing to disclose.

Managing Editor

Van Perry, MD, Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas Health Science Center
Van Perry, MD is a member of the following medical societies: American Academy of Dermatology and American Society for Laser Medicine and Surgery
Disclosure: Nothing to disclose.

CME Editor

Joel M Gelfand, MD, MSCE, Medical Director, Clinical Studies Unit, Assistant Professor, Department of Dermatology, Associate Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania
Joel M Gelfand, MD, MSCE is a member of the following medical societies: Society for Investigative Dermatology
Disclosure: AMGEN Consulting fee Consulting; AMGEN Grant/research funds None; Genentech Consulting fee Consulting; Centocor Consulting fee Consulting; Centocor Grant/research funds None; Covance Consulting fee Consulting; Shire  Consulting

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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