eMedicine Specialties > Dermatology > Pediatric Diseases
Fibrodysplasia Ossificans: Follow-up
Updated: Sep 4, 2009
Follow-up
Complications
Fibrodysplasia ossificans progressiva (FOP) is sometimes associated with alopecia and deafness.
Prognosis
The prognosis for fibrodysplasia ossificans progressiva is poor because of the involvement of thoracic muscles and restrictive lung disease. Most fibrodysplasia ossificans progressiva patients are bedridden by the time they are in their 30s, and they usually die before they reach age 40 years.
Miscellaneous
Special Concerns
A special concern is recognizing classic clinical features of fibrodysplasia ossificans progressiva prior to the appearance of heterotopic ossification, avoiding surgical interventions that may lead to irreversible iatrogenic harm.20
More on Fibrodysplasia Ossificans |
| Overview: Fibrodysplasia Ossificans |
| Differential Diagnoses & Workup: Fibrodysplasia Ossificans |
| Treatment & Medication: Fibrodysplasia Ossificans |
Follow-up: Fibrodysplasia Ossificans |
| Multimedia: Fibrodysplasia Ossificans |
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References
Feldman G, Li M, Martin S, et al. Fibrodysplasia ossificans progressiva, a heritable disorder of severe heterotopic ossification, maps to human chromosome 4q27-31. Am J Hum Genet. Jan 2000;66(1):128-35. [Medline].
de la Pena LS, Billings PC, Fiori JL, Ahn J, Kaplan FS, Shore EM. Fibrodysplasia ossificans progressiva (FOP), a disorder of ectopic osteogenesis, misregulates cell surface expression and trafficking of BMPRIA. J Bone Miner Res. Jul 2005;20(7):1168-76. [Medline].
Shore EM, Glaser DL, Gannon FH. Osteogenic induction in hereditary disorders of heterotopic ossification. Clin Orthop Relat Res. May 2000;303-16. [Medline].
Shore EM, Xu M, Feldman GJ, et al. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet. May 2006;38(5):525-7. [Medline].
Fontaine K, Semonin O, Legarde JP, Lenoir G, Lucotte G. A new mutation of the noggin gene in a French Fibrodysplasia ossificans progressiva (FOP) family. Genet Couns. 2005;16(2):149-54. [Medline].
Nakajima M, Haga N, Takikawa K, Manabe N, Nishimura G, Ikegawa S. The ACVR1 617G>A mutation is also recurrent in three Japanese patients with fibrodysplasia ossificans progressiva. J Hum Genet. 2007;52(5):473-5. [Medline].
Furuya H, Ikezoe K, Wang L, et al. A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H). Am J Med Genet A. Feb 15 2008;146A(4):459-63. [Medline].
Kaplan FS, Xu M, Seemann P, et al. Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1. Hum Mutat. Mar 2009;30(3):379-90. [Medline].
Petrie KA, Lee WH, Bullock AN, et al. Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients. PLoS One. 2009;4(3):e5005. [Medline].
Deirmengian GK, Hebela NM, O'Connell M, Glaser DL, Shore EM, Kaplan FS. Proximal tibial osteochondromas in patients with fibrodysplasia ossificans progressiva. J Bone Joint Surg Am. Feb 2008;90(2):366-74. [Medline].
Chichareon V, Arpornmaeklong P, Donsakul N. Fibrodysplasia ossificans progressiva and associated osteochondroma of the coronoid process in a child. Plast Reconstr Surg. Apr 1999;103(4):1238-43. [Medline].
Levy CE, Lash AT, Janoff HB, Kaplan FS. Conductive hearing loss in individuals with fibrodysplasia ossificans progressiva. Am J Audiol. Jun 1999;8(1):29-33. [Medline].
Aslan G, Celik F, Gorgu M. Unusual ankylosis of the jaw due to fibrodysplasia ossificans progressiva. Ann Plast Surg. Nov 1999;43(5):576-8. [Medline].
van der Meij EH, Becking AG, van der Waal I. Fibrodysplasia ossificans progressiva. An unusual cause of restricted mandibular movement. Oral Dis. Mar 2006;12(2):204-7. [Medline].
Jeziorska M, Dabska M, Buraczewski J. [Myositis ossificans (clinico-pathological entity often diagnosed erroneously as malignant tumor)]. Nowotwory. Apr-Jun 1980;30(2):183-94. [Medline].
Dzukou T, Barbier C, Spyckerelle C, Labarriere F, Vittu G, Kremp O. [Fibrodysplasia ossificans progressiva in children. The interest of early diagnosis and treatment]. Presse Med. Mar 12 2005;34(5):373-7. [Medline].
Kaplan FS, Glaser DL, Pignolo RJ, Shore EM. A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton. Expert Opin Biol Ther. May 2007;7(5):705-12. [Medline].
Kaplan FS, Le Merrer M, Glaser DL, et al. Fibrodysplasia ossificans progressiva. Best Pract Res Clin Rheumatol. Mar 2008;22(1):191-205. [Medline].
Altschuler EL. Consideration of Rituximab for fibrodysplasia ossificans progressiva. Med Hypotheses. 2004;63(3):407-8. [Medline].
Zaghloul KA, Heuer GG, Guttenberg MD, Shore EM, Kaplan FS, Storm PB. Lumbar puncture and surgical intervention in a child with undiagnosed fibrodysplasia ossificans progressiva. J Neurosurg Pediatr. Jan 2008;1(1):91-4. [Medline].
Ali NS, Qureshi R. A 3 year old girl with fibrodysplasia ossificans progressiva. J Pak Med Assoc. Sep 1999;49(9):223-5. [Medline].
Connor JM, Evans DA. Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients. J Bone Joint Surg Br. 1982;64(1):76-83. [Medline].
Kaplan FS. Skin and bones. Arch Dermatol. Jul 1996;132(7):815-8. [Medline].
Kapoor R, Gadre PM, Mattoo P, Agrawal R. Fibrodysplasia ossificans progressiva. Indian Pediatr. Aug 1998;35(8):786-8. [Medline].
Levy C, Berner TF, Sandhu PS, McCarty B, Denniston NL. Mobility challenges and solutions for fibrodysplasia ossificans progressiva. Arch Phys Med Rehabil. Oct 1999;80(10):1349-53. [Medline].
Lucotte G, Semonin O, Lutz P. A de novo heterozygous deletion of 42 base-pairs in the noggin gene of a fibrodysplasia ossificans progressiva patient. Clin Genet. Dec 1999;56(6):469-70. [Medline].
Magryta CJ, Kligora CJ, Temple HT, Malik RK. Clinical presentation of fibrodysplasia ossificans progressiva: pitfalls in diagnosis. J Pediatr Hematol Oncol. Nov-Dec 1999;21(6):539-43. [Medline].
Miller ES, Esterly NB, Fairley JA. Progressive osseous heteroplasia. Arch Dermatol. Jul 1996;132(7):787-91. [Medline].
Nucci A, Queiroz LD, Santos AD, Camargo EE, Moura-Ribeiro MV. Fibrodysplasia ossificans progressiva: case report. Arq Neuropsiquiatr. Jun 2000;58(2A):342-7. [Medline].
Puzas JE, Miller MD, Rosier RN. Pathologic bone formation. Clin Orthop Relat Res. Aug 1989;269-81. [Medline].
Smith R. 61st ENMC-sponsored international workshop: Fibrodysplasia (myositis) ossificans progressiva (FOP), 10-12th July 1998, Naarden, The Netherlands. Neuromuscul Disord. Oct 1999;9(6-7):434-5. [Medline].
Sy MH, Diouf A, Diallo BK, et al. [Fibrodysplasia ossificans progressiva or Munchmeyer disease apropos of 2 cases]. Dakar Med. 1999;44(1):126-30. [Medline].
Virdi AS, Shore EM, Oreffo RO, et al. Phenotypic and molecular heterogeneity in fibrodysplasia ossificans progressiva. Calcif Tissue Int. Sep 1999;65(3):250-5. [Medline].
Walsh JS, Fairley JA. Calcifying disorders of the skin. J Am Acad Dermatol. Nov 1995;33(5 Pt 1):693-706; quiz 707-10. [Medline].
Further Reading
Keywords
fibrodysplasia ossificans, fibrodysplasia ossificans progressiva, FOP, myositis ossificans progressiva, myositis ossificans
Follow-up: Fibrodysplasia Ossificans