Fibrodysplasia Ossificans: Multimedia

References

1. Feldman G, Li M, Martin S, et al. Fibrodysplasia ossificans progressiva, a heritable disorder of severe heterotopic ossification, maps to human chromosome 4q27-31. Am J Hum Genet. Jan 2000;66(1):128-35. [Medline].

2. de la Pena LS, Billings PC, Fiori JL, Ahn J, Kaplan FS, Shore EM. Fibrodysplasia ossificans progressiva (FOP), a disorder of ectopic osteogenesis, misregulates cell surface expression and trafficking of BMPRIA. J Bone Miner Res. Jul 2005;20(7):1168-76. [Medline].

3. Shore EM, Glaser DL, Gannon FH. Osteogenic induction in hereditary disorders of heterotopic ossification. Clin Orthop Relat Res. May 2000;303-16. [Medline].

4. Shore EM, Xu M, Feldman GJ, et al. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet. May 2006;38(5):525-7. [Medline].

5. Fontaine K, Semonin O, Legarde JP, Lenoir G, Lucotte G. A new mutation of the noggin gene in a French Fibrodysplasia ossificans progressiva (FOP) family. Genet Couns. 2005;16(2):149-54. [Medline].

6. Nakajima M, Haga N, Takikawa K, Manabe N, Nishimura G, Ikegawa S. The ACVR1 617G>A mutation is also recurrent in three Japanese patients with fibrodysplasia ossificans progressiva. J Hum Genet. 2007;52(5):473-5. [Medline].

7. Furuya H, Ikezoe K, Wang L, et al. A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H). Am J Med Genet A. Feb 15 2008;146A(4):459-63. [Medline].

8. Kaplan FS, Xu M, Seemann P, et al. Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1. Hum Mutat. Mar 2009;30(3):379-90. [Medline].

9. Petrie KA, Lee WH, Bullock AN, et al. Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients. PLoS One. 2009;4(3):e5005. [Medline].

10. Deirmengian GK, Hebela NM, O'Connell M, Glaser DL, Shore EM, Kaplan FS. Proximal tibial osteochondromas in patients with fibrodysplasia ossificans progressiva. J Bone Joint Surg Am. Feb 2008;90(2):366-74. [Medline].

11. Chichareon V, Arpornmaeklong P, Donsakul N. Fibrodysplasia ossificans progressiva and associated osteochondroma of the coronoid process in a child. Plast Reconstr Surg. Apr 1999;103(4):1238-43. [Medline].

12. Levy CE, Lash AT, Janoff HB, Kaplan FS. Conductive hearing loss in individuals with fibrodysplasia ossificans progressiva. Am J Audiol. Jun 1999;8(1):29-33. [Medline].

13. Aslan G, Celik F, Gorgu M. Unusual ankylosis of the jaw due to fibrodysplasia ossificans progressiva. Ann Plast Surg. Nov 1999;43(5):576-8. [Medline].

14. van der Meij EH, Becking AG, van der Waal I. Fibrodysplasia ossificans progressiva. An unusual cause of restricted mandibular movement. Oral Dis. Mar 2006;12(2):204-7. [Medline].

15. Jeziorska M, Dabska M, Buraczewski J. [Myositis ossificans (clinico-pathological entity often diagnosed erroneously as malignant tumor)]. Nowotwory. Apr-Jun 1980;30(2):183-94. [Medline].

16. Dzukou T, Barbier C, Spyckerelle C, Labarriere F, Vittu G, Kremp O. [Fibrodysplasia ossificans progressiva in children. The interest of early diagnosis and treatment]. Presse Med. Mar 12 2005;34(5):373-7. [Medline].

17. Kaplan FS, Glaser DL, Pignolo RJ, Shore EM. A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton. Expert Opin Biol Ther. May 2007;7(5):705-12. [Medline].

18. Kaplan FS, Le Merrer M, Glaser DL, et al. Fibrodysplasia ossificans progressiva. Best Pract Res Clin Rheumatol. Mar 2008;22(1):191-205. [Medline].

19. Altschuler EL. Consideration of Rituximab for fibrodysplasia ossificans progressiva. Med Hypotheses. 2004;63(3):407-8. [Medline].

20. Zaghloul KA, Heuer GG, Guttenberg MD, Shore EM, Kaplan FS, Storm PB. Lumbar puncture and surgical intervention in a child with undiagnosed fibrodysplasia ossificans progressiva. J Neurosurg Pediatr. Jan 2008;1(1):91-4. [Medline].

21. Ali NS, Qureshi R. A 3 year old girl with fibrodysplasia ossificans progressiva. J Pak Med Assoc. Sep 1999;49(9):223-5. [Medline].

22. Connor JM, Evans DA. Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients. J Bone Joint Surg Br. 1982;64(1):76-83. [Medline].

23. Kaplan FS. Skin and bones. Arch Dermatol. Jul 1996;132(7):815-8. [Medline].

24. Kapoor R, Gadre PM, Mattoo P, Agrawal R. Fibrodysplasia ossificans progressiva. Indian Pediatr. Aug 1998;35(8):786-8. [Medline].

25. Levy C, Berner TF, Sandhu PS, McCarty B, Denniston NL. Mobility challenges and solutions for fibrodysplasia ossificans progressiva. Arch Phys Med Rehabil. Oct 1999;80(10):1349-53. [Medline].

26. Lucotte G, Semonin O, Lutz P. A de novo heterozygous deletion of 42 base-pairs in the noggin gene of a fibrodysplasia ossificans progressiva patient. Clin Genet. Dec 1999;56(6):469-70. [Medline].

27. Magryta CJ, Kligora CJ, Temple HT, Malik RK. Clinical presentation of fibrodysplasia ossificans progressiva: pitfalls in diagnosis. J Pediatr Hematol Oncol. Nov-Dec 1999;21(6):539-43. [Medline].

28. Miller ES, Esterly NB, Fairley JA. Progressive osseous heteroplasia. Arch Dermatol. Jul 1996;132(7):787-91. [Medline].

29. Nucci A, Queiroz LD, Santos AD, Camargo EE, Moura-Ribeiro MV. Fibrodysplasia ossificans progressiva: case report. Arq Neuropsiquiatr. Jun 2000;58(2A):342-7. [Medline].

30. Puzas JE, Miller MD, Rosier RN. Pathologic bone formation. Clin Orthop Relat Res. Aug 1989;269-81. [Medline].

31. Smith R. 61st ENMC-sponsored international workshop: Fibrodysplasia (myositis) ossificans progressiva (FOP), 10-12th July 1998, Naarden, The Netherlands. Neuromuscul Disord. Oct 1999;9(6-7):434-5. [Medline].

32. Sy MH, Diouf A, Diallo BK, et al. [Fibrodysplasia ossificans progressiva or Munchmeyer disease apropos of 2 cases]. Dakar Med. 1999;44(1):126-30. [Medline].

33. Virdi AS, Shore EM, Oreffo RO, et al. Phenotypic and molecular heterogeneity in fibrodysplasia ossificans progressiva. Calcif Tissue Int. Sep 1999;65(3):250-5. [Medline].

34. Walsh JS, Fairley JA. Calcifying disorders of the skin. J Am Acad Dermatol. Nov 1995;33(5 Pt 1):693-706; quiz 707-10. [Medline].

Further Reading

Keywords

fibrodysplasia ossificans, fibrodysplasia ossificans progressiva, FOP, myositis ossificans progressiva, myositis ossificans

Contributor Information and Disclosures

Author

Robert A Schwartz, MD, MPH, Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School
Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and Sigma Xi
Disclosure: Nothing to disclose.

Coauthor(s)

Slawomir Majewski, MD, Professor and Director, Department of Dermatology and Venereology, Warsaw School of Medicine, Poland
Disclosure: Nothing to disclose.

Sebastian S Majewski, MD, Consulting Staff, Department of Dermatology, Military Institute of Health Services, Warsaw, Poland
Disclosure: Nothing to disclose.

Stefania Jablonska, MD, Chairman, Professor Emeritus, Department of Dermatology, Warsaw School of Medicine, Poland
Disclosure: Nothing to disclose.

Medical Editor

Jean Paul Ortonne, MD, Chair, Department of Dermatology, Professor, Hospital L'Archet, Nice University, France
Jean Paul Ortonne, MD is a member of the following medical societies: American Academy of Dermatology and American Dermatological Association
Disclosure: Nothing to disclose.

Pharmacy Editor

David F Butler, MD, Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Managing Editor

Jeffrey J Miller, MD, Associate Professor of Dermatology, Penn State University College of Medicine; Staff Dermatologist, Penn State Milton S Hershey Medical Center
Jeffrey J Miller, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Association of Professors of Dermatology, North American Hair Research Society, and Society for Investigative Dermatology
Disclosure: Nothing to disclose.

CME Editor

Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University
Catherine Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.