No effective therapy exists for acute hemorrhagic edema of infancy (AHEI). The use of steroids and antihistamines has been controversial, and they do not appear to alter the disease course. However, systemic corticosteroids may be used to ameliorate the acute manifestations of the disease.  Treatment is symptomatic; discontinue antibiotics after obtaining negative culture results.
Inpatient care is not usually required unless the diagnosis of acute hemorrhagic edema of infancy (AHEI) is in doubt. If meningococcemia or another significant condition remains in the differential diagnosis, patients may require monitoring or therapy as appropriate for those disorders.
Consult a dermatologist if the diagnosis of acute hemorrhagic edema of infancy (AHEI) is in doubt. Additionally, consult a gastroenterologist or nephrologist if significant abdominal symptoms or renal involvement is noted.
Acute hemorrhagic edema of infancy (AHEI) patients usually are nontoxic in appearance. Although visceral involvement is rare, maintain a relatively bland diet with plenty of fluids to maintain hydration.
No particular restrictions in activity are required for acute hemorrhagic edema of infancy (AHEI).
Rare reports have described complications such as arthritis, nephritis, [19, 20] abdominal pain, gastrointestinal tract bleeding, intussusception,  scrotal pain, compartment syndrome,  and testicular torsion. 
No known method exists for preventing acute hemorrhagic edema of infancy (AHEI) or recurrences of the condition.
Treatment for acute hemorrhagic edema of infancy (AHEI) is symptomatic. Monitor patients for abdominal or renal involvement, which, although rare, has been reported.
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