Acrokeratoelastoidosis Workup

  • Author: Enrico Ceccolini, MD; Chief Editor: William D James, MD   more...
 
Updated: Nov 21, 2011
 

Laboratory Studies

  • Laboratory studies or other studies are usually not necessary.
  • Biopsy can be helpful for diagnostic purposes and for ruling out other disorders.
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Histologic Findings

The typical epidermal features of acrokeratoelastoidosis are hyperkeratosis with hypergranulosis, acanthosis, and epidermal hyperplasia. Some of these findings may be absent.

The changes in the dermal elastic fibers are characteristic. The number of elastic fibers is often diminished, and the fibers have a discrete-to-intense fragmentation. An elastic fiber stain, such as the Weigert, Verhoeff, or orcein stain, may be useful in demonstrating this fragmentation. Periodic acid-Schiff (PAS) is used to stain carbohydrates, and occasionally, the PAS test is used to rule out other conditions. The cell walls of fungi are rich in carbohydrates, and they stain positively with PAS. PAS does not stain elastic fibers.

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Contributor Information and Disclosures
Author

Enrico Ceccolini, MD  Consulting Staff, Department of Dermatology, University of Bologna, Italy. Private Practice, Pesaro, Italy.

Enrico Ceccolini, MD is a member of the following medical societies: American Academy of Dermatology, International Society of Dermatology, and Society for Pediatric Dermatology

Disclosure: Nothing to disclose.

Coauthor(s)

Robert A Schwartz, MD, MPH  Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and Sigma Xi

Disclosure: Nothing to disclose.

Specialty Editor Board

Carrie L Kovarik, MD  Assistant Professor of Dermatology, Dermatopathology, and Infectious Diseases, University of Pennsylvania School of Medicine

Carrie L Kovarik, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

Michael J Wells, MD  Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

Warren R Heymann, MD  Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Glen H Crawford, MD  Assistant Clinical Professor, Department of Dermatology, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, The Pennsylvania Hospital

Glen H Crawford, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Phi Beta Kappa, and Society of USAF Flight Surgeons

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD  Paul R Gross Professor of Dermatology, University of Pennsylvania School of Medicine; Vice-Chair, Program Director, Department of Dermatology, University of Pennsylvania Health System

William D James, MD is a member of the following medical societies: American Academy of Dermatology and Society for Investigative Dermatology

Disclosure: Elsevier Royalty Other

References

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Courtesy of William D James, MD.
 
 
 
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