Dermatologic Manifestations of Wiskott-Aldrich Syndrome Treatment & Management
- Author: Akimichi Morita, MD, PhD; Chief Editor: Dirk M Elston, MD more...
Transfusions of platelets and plasma decrease the risk of fatal hemorrhage in Wiskott-Aldrich syndrome patients.
Appropriate antibiotics should be used to treat bacterial infections. The antibiotics should be chosen based on the bacteria obtained and detected from the infected site.
Intravenous infusions of immune globulin decrease the risks of infection.
Infusion of transfer factor results in decreased frequency of infection and improvement of eczema.
Bone marrow transplantation with HLA-identical marrow should be considered if patients have recurrent problems. Full engraftment results in normal platelet numbers and functions, immunologic status, and clearance of the eczema.
Topical steroids may improve the eczema.
Gene therapy is promising for Wiskott-Aldrich syndrome.[11, 12, 13]
Splenectomy should be considered for Wiskott-Aldrich syndrome patients with thrombocytopenia who have no HLA-matched bone marrow transplantation donor.[10, 14, 15]
Possible consultations include a pediatrician and/or oncologist.
In patients with food allergies, diet control must be considered.
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