Atrophia maculosa varioliformis cutis (AMVC) is a rare disease that presents as spontaneously formed facial scars in young adults. In 1918, Heidingsfeld  coined the disease name to describe the numerous spontaneously formed scars on the cheeks of a 20-year-old man.
Most commonly located on the cheeks, the scars vary in shape and size, resembling those from smallpox. A slight erythema or pruritus precedes the appearance of the scars by 1-2 days. The number of reports on this eruption in literature is limited, and even fewer are documented with skin biopsy specimens. Its etiology remains unknown, but elastic tissue pathology has been reported in histology findings.
Although its etiology is unknown, atrophia maculosa varioliformis cutis (AMVC) may represent an underlying defect of dermal elastin as demonstrated by histologic and ultrastructural findings.  AMVC has been documented only in the skin.
No racial predilection is reported for atrophia maculosa varioliformis cutis (AMVC).
The female-to-male ratio for atrophia maculosa varioliformis cutis (AMVC) is approximately equal.
The reported age range of atrophia maculosa varioliformis cutis (AMVC) varies from 5-37 years,  with the disorder usually appearing in young adulthood.