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Reticulate Pigmented Anomaly Differential Diagnoses

  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
Updated: Jun 24, 2016

Diagnostic Considerations

Also consider the following:

  • Kitamura reticulate acropigmentation [30]
  • Haber syndrome [31]
  • Galli-Galli disease [32] - Best considered a subtype of Dowling-Degos disease (reticulate pigmented anomaly) with clinical and histologic features similar to transient acantholytic dermatosis [33]
  • Epidermolysis bullosa with mottled pigmentation
  • Scleroderma - May rarely be associated reticulate hyperpigmentation of the trunk, upper limbs, and lower limbs [34]

The coexistent Dowling-Degos disease and reticulate acropigmentation of Kitamura with progressive multiple common seborrheic keratoses has been described in a family.[35]

Galli-Galli disease, a variant of Dowling-Degos disease, has been described as occurring in a liver transplant recipient with Grover diseaselike, erythematous, keratotic, excoriated papules, and lentigolike macules with predilection for the trunk.[36]

Galli-Galli disease, Dowling-Degos disease, Kitamura disease, Haber syndrome, and reticulate acropigmentation of Dohi may be clinically similar and require careful distinction.[37]  Rarely Dowling-Degos disease may coexist with Darier disease.[38]

Differential Diagnoses

Contributor Information and Disclosures

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public Affairs and Administration

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, New York Academy of Medicine, American Academy of Dermatology, American College of Physicians, Sigma Xi

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Warren R Heymann, MD Head, Division of Dermatology, Professor, Department of Internal Medicine, Rutgers New Jersey Medical School

Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.


Mark A Crowe, MD Assistant Clinical Instructor, Department of Medicine, Division of Dermatology, University of Washington School of Medicine

Mark A Crowe, MD is a member of the following medical societies: American Academy of Dermatology and North American Clinical Dermatologic Society

Disclosure: Nothing to disclose.

Borys Savchyk, MD, PhD Director, Molecular Biology Institute, Medical University of Lviv, Ukraine

Disclosure: Nothing to disclose.

Alexander Zajchenko, MD Head, Professor, Department of Skin and Venereal Diseases, Medical University of Lviv, Ukraine

Disclosure: Nothing to disclose.

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Speckled macules on the male external genitalia.
Histologic view showing elongated thin rete ridges with melanin concentrated at the tips (hematoxylin and eosin).
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