eMedicine Specialties > Dermatology > Pediatric Diseases

Reticulate Pigmented Anomaly: Follow-up

Author: Robert A Schwartz, MD, MPH, Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School
Contributor Information and Disclosures

Updated: Jul 27, 2009

Follow-up

Prognosis

Dowling-Degos disease (reticulate pigmented anomaly) is slowly progressive but not life threatening.

Patient Education

The patient and his or her family should be educated about the common autosomal dominant nature of Dowling-Degos disease (reticulate pigmented anomaly).

 
Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous authors, Alexander Zajchenko, MD, and Borys Savchyk, MD, and previous Chief Editor, William D. James, MD, to the development and writing of this article.



More on Reticulate Pigmented Anomaly

Overview: Reticulate Pigmented Anomaly
Differential Diagnoses & Workup: Reticulate Pigmented Anomaly
Treatment & Medication: Reticulate Pigmented Anomaly
Follow-up: Reticulate Pigmented Anomaly
Multimedia: Reticulate Pigmented Anomaly
References
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References

  1. Dowling GD, Freudenthal W. Acanthosis nigricans. Proc Roy Soc Med. 1938;31:1147-50.

  2. Degos R, Ossipowski B. [Reticulated pigmentary dermatosis of the folds: relation to acanthosis nigricans.]. Ann Dermatol Syphiligr (Paris). Mar-Apr 1954;81(2):147-51. [Medline].

  3. Schwartz RA, Birnkrant AP, Burgess GH, Stoll HL Jr, Yaqub M, Fox MD. Reticulate pigmented anomaly. Cutis. Oct 1980;26(4):380-1. [Medline].

  4. Drut R, Pollono D, Drut RM. Bilateral nephroblastoma in familial Hay-Wells syndrome associated with familial reticulate pigmentation of the skin. Am J Med Genet. Jun 15 2002;110(2):164-9. [Medline].

  5. Müller CS, Pföhler C, Tilgen W. Changing a concept--controversy on the confusing spectrum of the reticulate pigmented disorders of the skin. J Cutan Pathol. Jan 2009;36(1):44-8. [Medline].

  6. El Shabrawi-Caelen L, Rütten A, Kerl H. The expanding spectrum of Galli-Galli disease. J Am Acad Dermatol. May 2007;56(5 Suppl):S86-91. [Medline].

  7. Brown WG. Reticulate pigmented anomaly of the flexures. Case reports and genetic investigation. Arch Dermatol. Jul 1982;118(7):490-3. [Medline].

  8. Li CR, Xing QH, Li M, et al. A gene locus responsible for reticulate pigmented anomaly of the flexures maps to chromosome 17p13.3. J Invest Dermatol. Jun 2006;126(6):1297-301. [Medline].

  9. Betz RC, Planko L, Eigelshoven S, et al. Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease. Am J Hum Genet. Mar 2006;78(3):510-9. [Medline].

  10. Liao H, Zhao Y, Baty DU, McGrath JA, Mellerio JE, McLean WH. A heterozygous frameshift mutation in the V1 domain of keratin 5 in a family with Dowling-Degos disease. J Invest Dermatol. Feb 2007;127(2):298-300. [Medline].

  11. Jones EW, Grice K. Reticulate pigmented anomaly of the flexures. Dowing Degos disease, a new genodermatosis. Arch Dermatol. Aug 1978;114(8):1150-7. [Medline].

  12. Kim YC, Davis MD, Schanbacher CF, Su WP. Dowling-Degos disease (reticulate pigmented anomaly of the flexures): a clinical and histopathologic study of 6 cases. J Am Acad Dermatol. Mar 1999;40(3):462-7. [Medline].

  13. Zuo YG, Ho M, Jin HZ, Wang BX. Case report: a case of newborn onset reticulate pigmented anomaly of the flexures in a Chinese female. J Eur Acad Dermatol Venereol. Jul 2008;22(7):901-3. [Medline].

  14. Sandhu K, Saraswat A, Kanwar AJ. Dowling-Degos disease with dyschromatosis universalis hereditaria-like pigmentation in a family. J Eur Acad Dermatol Venereol. Nov 2004;18(6):702-4. [Medline].

  15. Loo WJ, Rytina E, Todd PM. Hidradenitis suppurativa, Dowling-Degos and multiple epidermal cysts: a new follicular occlusion triad. Clin Exp Dermatol. Nov 2004;29(6):622-4. [Medline].

  16. O'Goshi K, Terui T, Tagami H. Dowling-Degos disease affecting the vulva. Acta Derm Venereol. May 2001;81(2):148. [Medline].

  17. Massone C, Hofmann-Wellenhof R. Dermoscopy of Dowling-Degos disease of the vulva. Arch Dermatol. Mar 2008;144(3):417-8. [Medline].

  18. Bedlow AJ, Mortimer PS. Dowling-Degos disease associated with hidradenitis suppurativa. Clin Exp Dermatol. Jul 1996;21(4):305-6. [Medline].

  19. Fenske NA, Groover CE, Lober CW, Espinoza CG. Dowling-Degos disease, hidradenitis suppurativa, and multiple keratoacanthomas. A disorder that may be caused by a single underlying defect in pilosebaceous epithelial proliferation. J Am Acad Dermatol. May 1991;24(5 Pt 2):888-92. [Medline].

  20. Lee SJ, Lee HJ, Kim DW, Jun JB, Chung SL, Bae HI. A case of Dowling-Degos disease suggesting an evolutional sequence. J Dermatol. Sep 2000;27(9):591-7. [Medline].

  21. Nishizawa A, Nakano H, Satoh T, Takayama K, Sawamura D, Yokozeki H. Haber's syndrome may be a clinical entity different from Dowling-Degos disease. Br J Dermatol. Jan 2009;160(1):215-7. [Medline].

  22. Braun-Falco M, Volgger W, Borelli S, Ring J, Disch R. Galli-Galli disease: an unrecognized entity or an acantholytic variant of Dowling-Degos disease?. J Am Acad Dermatol. Nov 2001;45(5):760-3. [Medline].

  23. Gilchrist H, Jackson S, Morse L, Nicotri T, Nesbitt LT. Galli-Galli disease: A case report with review of the literature. J Am Acad Dermatol. Feb 2008;58(2):299-302. [Medline].

  24. Ee HL, Tan SH. Reticulate hyperpigmented scleroderma: a new pigmentary manifestation. Clin Exp Dermatol. Mar 2005;30(2):131-3. [Medline].

  25. Zhang RZ, Zhu WY. A study of immunohistochemical and electron microscopic changes in Dowling-Degos disease. J Dermatol. Jan 2005;32(1):12-8. [Medline].

  26. Altomare G, Capella GL, Fracchiolla C, Frigerio E. Effectiveness of topical adapalene in Dowling-Degos disease. Dermatology. 1999;198(2):176-7. [Medline].

  27. Boyle J, Burton JL. Reticulate pigmented anomaly of the flexures and seborrhoeic warts. Clin Exp Dermatol. Jul 1985;10(4):379-83. [Medline].

  28. Kikuchi I. Evolution of Dowling Degos disease. J Dermatol. Dec 2000;27(12):806. [Medline].

  29. Oiso N, Tsuruta D, Ota T, Kobayashi H, Kawada A. Spotted and rippled reticulate hypermelanosis: a possible variant of Dowling-Degos disease. Br J Dermatol. Jan 2007;156(1):196-8. [Medline].

  30. Starzycki Z. [Case of reticulate pigmented anomaly of the flexures Dowling-Degos]. Przegl Dermatol. May-Jun 1981;68(3):383-7. [Medline].

  31. Tappero JW, Kershenovich J, Berger TG. Combined acral and flexural reticulate pigmentary anomaly. Arch Dermatol. Oct 1992;128(10):1411-2. [Medline].

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Further Reading

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Keywords

reticulate pigmented anomaly, Dowling-Degos disease, dark dot disease, Dowling Degos Ossipowski disease, DDD

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Contributor Information and Disclosures

Author

Robert A Schwartz, MD, MPH, Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School
Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and Sigma Xi
Disclosure: Nothing to disclose.

Medical Editor

Mark A Crowe, MD, Assistant Clinical Instructor, Department of Medicine, Division of Dermatology, University of Washington School of Medicine
Mark A Crowe, MD is a member of the following medical societies: American Academy of Dermatology and North American Clinical Dermatologic Society
Disclosure: Nothing to disclose.

Pharmacy Editor

David F Butler, MD, Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Managing Editor

Warren R Heymann, MD, Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey
Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology
Disclosure: Nothing to disclose.

CME Editor

Glen H Crawford, MD, Assistant Clinical Professor, Department of Dermatology, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, The Pennsylvania Hospital
Glen H Crawford, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Phi Beta Kappa, and Society of USAF Flight Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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