eMedicine Specialties > Dermatology > Photo-Related Diseases
Actinic Prurigo: Follow-up
Updated: Jan 15, 2009
Follow-up
Further Inpatient Care
- The need of inpatient care for patients with Actinic prurigo is extremely infrequent.
Deterrence/Prevention
- Long-term precautions are important to avoid worsening of the condition. Therefore, patients should be aware of the sunniest months of the year to reduce outbreaks.
- Photoprotection is important. Explaining the nature of the disease to patients is mandatory because they must protect themselves from the sun with sunglasses, hats, umbrellas, long sleeves, high neck shirts, and appropriate clothing on a daily basis. Patients must also avoid sun exposure between 9:00 am and 6:00 pm, even during the winter.
- Sunscreens are only an adjunctive treatment. They do not represent a reliable control treatment. Physical sunscreens could be better than chemical sunscreens, especially in cases where excoriation is present and a burning sensation can be elicited.
- Outdoor shade is not enough to provide photoprotection. Regularly, trees reduce ultraviolet light only by half.
- Staying indoors could also be unsafe because window glasses do not filter long wavelengths (UV-A 315-400 nm). This is especially problematic when people who are affected work close to windows.
Complications
- Common complications are secondary infection and irritant contact dermatitis, mainly due to the use of sunscreens. Impetigo is another typical complication.
Prognosis
- The prognosis is poor, with frequent relapses, especially during spring and summer. Actinic prurigo does not improve with time, contrary to what happens in PLE.
Patient Education
- Teaching patients how to apply sunscreen is important. In the early phases of treatment, patients may not apply it properly; they may spread the cream all over their skin without allowing it to fully absorb. Therefore, teach patients to try to reach at least a 2-mg/cm2 dose on the exposed areas.
- The patient should be aware of the UV index. The UV index forecast is usually available on the Internet or through the media in many parts of the world.
- Patients should know that actinic prurigo is not a dose-dependent disease, and, similar to all immune-mediated hypersensitivity disorders, a minor amount of the offensive agent may provoke outbreaks.
Miscellaneous
Medicolegal Pitfalls
- Failure to regularly supervise patients and to inform them of the possibility of exacerbation during spring and summer months is a pitfall.
- Failure to monitor the use of thalidomide in women, especially those of childbearing age, is a pitfall. Birth control measures must always be implemented.
Special Concerns
- Certifying to proper authorities that patients do not have a contagious or infectious disease is important.
- Women of childbearing age must be supervised monthly if oral drugs are being administrated.
The authors and editors of eMedicine gratefully acknowledge the contributions of previous author, Veronica Lepe Murillo, MD, to the development and writing of this article.
More on Actinic Prurigo |
| Overview: Actinic Prurigo |
| Differential Diagnoses & Workup: Actinic Prurigo |
| Treatment & Medication: Actinic Prurigo |
Follow-up: Actinic Prurigo |
| Multimedia: Actinic Prurigo |
| References |
| « Previous Page | Next Page » |
References
Cazarin-Barrientos J, Roman D, Messina M. Talidomida en ninos con prurigo solar refractario. Actas Dermatol Dermatopatol. 2002;1:11-5.
Herrera-Geopfert R, Magana M. Follicular cheilitis. A distinctive histopathologic finding in actinic prurigo. Am J Dermatopathol. Aug 1995;17(4):357-61. [Medline].
Magana M, Mendez Y, Rodriguez A, Mascott M. The conjunctivitis of solar (actinic) prurigo. Pediatr Dermatol. Nov-Dec 2000;17(6):432-5. [Medline].
Moncada B, Gonzalez-Amaro R, Baranda ML, Loredo C, Urbina R. Immunopathology of polymorphous light eruption. T lymphocytes in blood and skin. J Am Acad Dermatol. Jun 1984;10(6):970-3. [Medline].
Gonzalez-Amaro R, Baranda L, Salazar-Gonzalez JF, Abud-Mendoza C, Moncada B. Immune sensitization against epidermal antigens in polymorphous light eruption. J Am Acad Dermatol. Jan 1991;24(1):70-3. [Medline].
Santos-Martinez L, Llorente L, Baranda L, Richaud-Patin Y, Torres-Alvarez B, Moncada B, et al. Profile of cytokine mRNA expression in spontaneous and UV-induced skin lesions from actinic prurigo patients. Exp Dermatol. Apr 1997;6(2):91-7. [Medline].
Torres-Alvarez B, Baranda L, Fuentes C, Delgado C, Santos-Martinez L, Portales-Perez D, et al. An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. Eur J Dermatol. Feb 1998;8(1):24-8. [Medline].
Gonzalez-Rodriguez G, Ocadiz-Delgado R. [T and B clonal populations in actinic prurigo, a photodermatosis]. Gac Med Mex. Jan-Feb 2001;137(1):15-20. [Medline].
Wiseman MC, Orr PH, Macdonald SM, Schroeder ML, Toole JW. Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. J Am Acad Dermatol. Jun 2001;44(6):952-6. [Medline].
Schnell AH, Elston RC, Hull PR, Lane PR. Major gene segregation of actinic prurigo among North American Indians in Saskatchewan. Am J Med Genet. May 29 2000;92(3):212-9. [Medline].
Bernal JE, Duran de Rueda MM, Ordonez CP, Duran C, de Brigard D. Actinic prurigo among the Chimila Indians in Colombia: HLA studies. J Am Acad Dermatol. Jun 1990;22(6 Pt 1):1049-51. [Medline].
Sheridan DP, Lane PR, Irvine J, Martel MJ, Hogan DJ. HLA typing in actinic prurigo. J Am Acad Dermatol. Jun 1990;22(6 Pt 1):1019-23. [Medline].
Hojyo-Tomoka T, Granados J, Vargas-Alarcon G, Yamamoto-Furusho JK, Vega-Memije E, Cortes-Franco R, et al. Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo. J Am Acad Dermatol. Jun 1997;36(6 Pt 1):935-7. [Medline].
Surez A, Valbuena MC, Rey M, de Porras Quintana L. Association of HLA subtype DRB10407 in Colombian patients with actinic prurigo. Photodermatol Photoimmunol Photomed. Apr 2006;22(2):55-8. [Medline].
Menage H duP , Vaughan RW, Baker CS, Page G, Proby CM, Breathnach SM, et al. HLA-DR4 may determine expression of actinic prurigo in British patients. J Invest Dermatol. Feb 1996;106(2):362-7. [Medline].
Zuloaga-Salcedo S, Castillo-Vazquez M, Vega-Memije E, Arellano-Campos O, Rodriguez-Perez JM, Perez-Hernandez N, et al. Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. Br J Dermatol. 2007;156(5):1074-75. [Medline].
Grabczynska SA, McGregor JM, Kondeatis E, Vaughan RW, Hawk JL. Actinic prurigo and polymorphic light eruption: common pathogenesis and the importance of HLA-DR4/DRB1*0407. Br J Dermatol. Feb 1999;140(2):232-6. [Medline].
Hojyo-Tomoka T, Vega-Memije E, Granados J, Flores O, Cortes-Franco R, Teixeira F, et al. Actinic prurigo: an update. Int J Dermatol. Jun 1995;34(6):380-4. [Medline].
Hojyo-Tomoka MT, Vega-Memije ME, Cortes-Franco R, Dominguez-Soto L. Diagnosis and treatment of actinic prurigo. Dermatol Ther. 2003;16(1):40-4. [Medline].
Batard ML, Bonnevalle A, Segard M, Danze PM, Thomas P. Caucasian actinic prurigo: 8 cases observed in France. Br J Dermatol. Jan 2001;144(1):194-6. [Medline].
Worret WI, Vocks E, Frias G, Burgdorf WH, Lane P. [Actinic prurigo. An assessment of current status]. Hautarzt. Jul 2000;51(7):474-8. [Medline].
Kuno Y, Sato K, Hasegawa K, Tsuji T. A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). Photodermatol Photoimmunol Photomed. 2000;16:38-41. [Medline].
Wong SN, Khoo LS. Analysis of photodermatoses seen in a predominantly Asian population at a photodermatology clinic in Singapore. Photodermatol Photoimmunol Photomed. 2005;21:40-44. [Medline].
Akaraphanth R, Gritiyarangsan P. A case of actinic prurigo in Thailand. J Dermatol. Jan 2000;27(1):20-3. [Medline].
Crouch R, Foley P, Baker C. Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. Australas J Dermatol. May 2002;43(2):128-32. [Medline].
Jong CT, Finlay AY, Pearse AD, Kerr AC, Ferguson J, Benton EC, et al. The quality of life of 790 patients with photodermatoses. Br J Dermatol. 2008;159(1):192-97. [Medline].
Magana M. Actinic or solar prurigo. J Am Acad Dermatol. Mar 1997;36(3 Pt 1):504-5. [Medline].
Estrada-G I, Garibay-Escobar A, Nunez-Vazquez A, Hojyo-Tomoka T, Vega-Memije E, Cortes-Franco R, et al. Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. Int J Dermatol. 2004;43:893-897. [Medline].
Londono F. Thalidomide in the treatment of actinic prurigo. Int J Dermatol. Sep-Oct 1973;12(5):326-8. [Medline].
Moncada B, Baranda ML, Gonzalez-Amaro R, Urbina R, Loredo CE. Thalidomide--effect on T cell subsets as a possible mechanism of action. Int J Lepr Other Mycobact Dis. Jun 1985;53(2):201-5. [Medline].
Torres-Alvarez B, Castanedo-Cazares JP, Moncada B. Pentoxifylline in the treatment of actinic prurigo. A preliminary report of 10 patients. Dermatology. 2004;208(3):198-201. [Medline].
McCoombes JA, Hirst LW, Green WR. Use of topical cyclosporin for conjunctival manifestations of actinic prurigo. Am J Ophthalmol. 2000;130(6):830-831. [Medline].
Millard TP, Kondeatis E, Cox A, Wilson AG, Grabczynska SA, Carey BS, et al. A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. Br J Dermatol. Aug 2001;145(2):229-36. [Medline].
Further Reading
Keywords
actinic prurigo, AP, polymorphous light eruption of prurigo type, PLE, solar prurigo, solar dermatitis of the high plains
Follow-up: Actinic Prurigo