eMedicine Specialties > Dermatology > Photo-Related Diseases
Actinic Prurigo: Multimedia
Updated: Jan 15, 2009
Multimedia
![]() | Media file 1: Itchy plaques mainly on photoexposed areas of the face; these plaques are characteristic of actinic prurigo. |
![]() | Media file 2: Photodistribution of lesions over the body. |
![]() | Media file 3: Multiple itchy papules coalescing into plaques on the neck. These lesions are similar to lesions of polymorphous light eruption. Note the excoriations induced by scratching. |
![]() | Media file 4: One third of patients are children. The nose is frequently affected. This clinical feature is useful in distinguishing it from other entities, such as atopic dermatitis. |
![]() | Media file 5: One half of patients have bilateral conjunctivitis. Eye protection is needed to avoid disease progression. |
![]() | Media file 6: About 75% of patients have cheilitis, which can take the form of solid lesions or erosions. |
![]() | Media file 7: A phototest with UV-B light shows reproduction of lesions on the inner aspect of the arm. The result from the phototest with UV-A light was negative. |
![]() | Media file 8: Histologic examination shows acanthosis, mild spongiosis, edema of the lamina propria, and a moderate-to-dense perivascular lymphocytic inflammatory infiltrate. |
![]() | Media file 9: A close-up view shows edema of the lamina propria as well as a lymphocytic inflammatory infiltrate in the dermis. |
![]() | Media file 11: Actinic cheilitis resulting from actinic prurigo. |
More on Actinic Prurigo |
| Overview: Actinic Prurigo |
| Differential Diagnoses & Workup: Actinic Prurigo |
| Treatment & Medication: Actinic Prurigo |
| Follow-up: Actinic Prurigo |
Multimedia: Actinic Prurigo |
| References |
| « Previous Page |
References
Cazarin-Barrientos J, Roman D, Messina M. Talidomida en ninos con prurigo solar refractario. Actas Dermatol Dermatopatol. 2002;1:11-5.
Herrera-Geopfert R, Magana M. Follicular cheilitis. A distinctive histopathologic finding in actinic prurigo. Am J Dermatopathol. Aug 1995;17(4):357-61. [Medline].
Magana M, Mendez Y, Rodriguez A, Mascott M. The conjunctivitis of solar (actinic) prurigo. Pediatr Dermatol. Nov-Dec 2000;17(6):432-5. [Medline].
Moncada B, Gonzalez-Amaro R, Baranda ML, Loredo C, Urbina R. Immunopathology of polymorphous light eruption. T lymphocytes in blood and skin. J Am Acad Dermatol. Jun 1984;10(6):970-3. [Medline].
Gonzalez-Amaro R, Baranda L, Salazar-Gonzalez JF, Abud-Mendoza C, Moncada B. Immune sensitization against epidermal antigens in polymorphous light eruption. J Am Acad Dermatol. Jan 1991;24(1):70-3. [Medline].
Santos-Martinez L, Llorente L, Baranda L, Richaud-Patin Y, Torres-Alvarez B, Moncada B, et al. Profile of cytokine mRNA expression in spontaneous and UV-induced skin lesions from actinic prurigo patients. Exp Dermatol. Apr 1997;6(2):91-7. [Medline].
Torres-Alvarez B, Baranda L, Fuentes C, Delgado C, Santos-Martinez L, Portales-Perez D, et al. An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. Eur J Dermatol. Feb 1998;8(1):24-8. [Medline].
Gonzalez-Rodriguez G, Ocadiz-Delgado R. [T and B clonal populations in actinic prurigo, a photodermatosis]. Gac Med Mex. Jan-Feb 2001;137(1):15-20. [Medline].
Wiseman MC, Orr PH, Macdonald SM, Schroeder ML, Toole JW. Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. J Am Acad Dermatol. Jun 2001;44(6):952-6. [Medline].
Schnell AH, Elston RC, Hull PR, Lane PR. Major gene segregation of actinic prurigo among North American Indians in Saskatchewan. Am J Med Genet. May 29 2000;92(3):212-9. [Medline].
Bernal JE, Duran de Rueda MM, Ordonez CP, Duran C, de Brigard D. Actinic prurigo among the Chimila Indians in Colombia: HLA studies. J Am Acad Dermatol. Jun 1990;22(6 Pt 1):1049-51. [Medline].
Sheridan DP, Lane PR, Irvine J, Martel MJ, Hogan DJ. HLA typing in actinic prurigo. J Am Acad Dermatol. Jun 1990;22(6 Pt 1):1019-23. [Medline].
Hojyo-Tomoka T, Granados J, Vargas-Alarcon G, Yamamoto-Furusho JK, Vega-Memije E, Cortes-Franco R, et al. Further evidence of the role of HLA-DR4 in the genetic susceptibility to actinic prurigo. J Am Acad Dermatol. Jun 1997;36(6 Pt 1):935-7. [Medline].
Surez A, Valbuena MC, Rey M, de Porras Quintana L. Association of HLA subtype DRB10407 in Colombian patients with actinic prurigo. Photodermatol Photoimmunol Photomed. Apr 2006;22(2):55-8. [Medline].
Menage H duP , Vaughan RW, Baker CS, Page G, Proby CM, Breathnach SM, et al. HLA-DR4 may determine expression of actinic prurigo in British patients. J Invest Dermatol. Feb 1996;106(2):362-7. [Medline].
Zuloaga-Salcedo S, Castillo-Vazquez M, Vega-Memije E, Arellano-Campos O, Rodriguez-Perez JM, Perez-Hernandez N, et al. Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo. Br J Dermatol. 2007;156(5):1074-75. [Medline].
Grabczynska SA, McGregor JM, Kondeatis E, Vaughan RW, Hawk JL. Actinic prurigo and polymorphic light eruption: common pathogenesis and the importance of HLA-DR4/DRB1*0407. Br J Dermatol. Feb 1999;140(2):232-6. [Medline].
Hojyo-Tomoka T, Vega-Memije E, Granados J, Flores O, Cortes-Franco R, Teixeira F, et al. Actinic prurigo: an update. Int J Dermatol. Jun 1995;34(6):380-4. [Medline].
Hojyo-Tomoka MT, Vega-Memije ME, Cortes-Franco R, Dominguez-Soto L. Diagnosis and treatment of actinic prurigo. Dermatol Ther. 2003;16(1):40-4. [Medline].
Batard ML, Bonnevalle A, Segard M, Danze PM, Thomas P. Caucasian actinic prurigo: 8 cases observed in France. Br J Dermatol. Jan 2001;144(1):194-6. [Medline].
Worret WI, Vocks E, Frias G, Burgdorf WH, Lane P. [Actinic prurigo. An assessment of current status]. Hautarzt. Jul 2000;51(7):474-8. [Medline].
Kuno Y, Sato K, Hasegawa K, Tsuji T. A case of actinic prurigo showing hypersensitivity of skin fibroblasts to ultraviolet A (UVA). Photodermatol Photoimmunol Photomed. 2000;16:38-41. [Medline].
Wong SN, Khoo LS. Analysis of photodermatoses seen in a predominantly Asian population at a photodermatology clinic in Singapore. Photodermatol Photoimmunol Photomed. 2005;21:40-44. [Medline].
Akaraphanth R, Gritiyarangsan P. A case of actinic prurigo in Thailand. J Dermatol. Jan 2000;27(1):20-3. [Medline].
Crouch R, Foley P, Baker C. Actinic prurigo: a retrospective analysis of 21 cases referred to an Australian photobiology clinic. Australas J Dermatol. May 2002;43(2):128-32. [Medline].
Jong CT, Finlay AY, Pearse AD, Kerr AC, Ferguson J, Benton EC, et al. The quality of life of 790 patients with photodermatoses. Br J Dermatol. 2008;159(1):192-97. [Medline].
Magana M. Actinic or solar prurigo. J Am Acad Dermatol. Mar 1997;36(3 Pt 1):504-5. [Medline].
Estrada-G I, Garibay-Escobar A, Nunez-Vazquez A, Hojyo-Tomoka T, Vega-Memije E, Cortes-Franco R, et al. Evidence that thalidomide modifies the immune response of patients suffering from actinic prurigo. Int J Dermatol. 2004;43:893-897. [Medline].
Londono F. Thalidomide in the treatment of actinic prurigo. Int J Dermatol. Sep-Oct 1973;12(5):326-8. [Medline].
Moncada B, Baranda ML, Gonzalez-Amaro R, Urbina R, Loredo CE. Thalidomide--effect on T cell subsets as a possible mechanism of action. Int J Lepr Other Mycobact Dis. Jun 1985;53(2):201-5. [Medline].
Torres-Alvarez B, Castanedo-Cazares JP, Moncada B. Pentoxifylline in the treatment of actinic prurigo. A preliminary report of 10 patients. Dermatology. 2004;208(3):198-201. [Medline].
McCoombes JA, Hirst LW, Green WR. Use of topical cyclosporin for conjunctival manifestations of actinic prurigo. Am J Ophthalmol. 2000;130(6):830-831. [Medline].
Millard TP, Kondeatis E, Cox A, Wilson AG, Grabczynska SA, Carey BS, et al. A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo. Br J Dermatol. Aug 2001;145(2):229-36. [Medline].
Further Reading
Keywords
actinic prurigo, AP, polymorphous light eruption of prurigo type, PLE, solar prurigo, solar dermatitis of the high plains






















Multimedia: Actinic Prurigo