eMedicine Specialties > Dermatology > Reactive & Inflammatory Dermatoses
Vesicular Palmoplantar Eczema: Follow-up
Updated: Oct 30, 2009
Follow-up
Deterrence/Prevention
- Elimination of known exacerbating factors, although often difficult to accomplish, is crucial in preventing relapses of vesicular palmoplantar eczema.
Prognosis
- Acute vesicular eczema (pompholyx) in both major and minor forms tends to occur intermittently or sporadically and becomes less common as patients age. Episodes are less frequent from middle age onward.
- The prognosis is less satisfactory for subacute and chronic forms of vesicular and hyperkeratotic eczema, which often persist for years, than for other forms.
Patient Education
- For excellent patient education resources, visit eMedicine’s Skin, Hair, and Nails Center. Also, see eMedicine’s patient education article Eczema.
Miscellaneous
Medicolegal Pitfalls
- Failure to investigate for other possible diagnoses, such as contact dermatitis, palmoplantar pustular psoriasis, and pustular bacterid, is a pitfall.
- Failure to inform patients about the potential atrophy of the skin and/or increased risk of secondary infection that occurs with prolonged application of potent topical steroids is another pitfall. Consider potential systemic adverse effects, such as hyperglycemia, osteoporosis, and weight gain in patients receiving long-term treatment with systemic steroids.
- Failure to monitor and inform patients with recurrent episodes of the possible long-term effects of immunosuppressive drugs (eg, liver and kidney damage, increased risks of neoplasia) is another pitfall.
Special Concerns
- Vesicular and hyperkeratotic eczema is a major cause of disability and may result in long periods of occupational limitations.
- Provide emotional support and psychological counseling to patients, with particular sensitivity to the concerns and needs of patients and their families in view of the chronic nature of the disease.
The authors and editors of eMedicine gratefully acknowledge the contributions of previous authors, (1) Spiros Gramvussakis, MD; (2) John D Wilkinson, MBBS, MRCS, FRCP; and (3) Raeesa W Mirza, MD, MBBS, to the development and writing of this article.
More on Vesicular Palmoplantar Eczema |
| Overview: Vesicular Palmoplantar Eczema |
| Differential Diagnoses & Workup: Vesicular Palmoplantar Eczema |
| Treatment & Medication: Vesicular Palmoplantar Eczema |
Follow-up: Vesicular Palmoplantar Eczema |
| Multimedia: Vesicular Palmoplantar Eczema |
| References |
| « Previous Page | Next Page » |
References
Chen JJ, Liang YH, Zhou FS, et al. The gene for a rare autosomal dominant form of pompholyx maps to chromosome 18q22.1-18q22.3. J Invest Dermatol. Feb 2006;126(2):300-4. [Medline].
Edman B. Palmar eczema: a pathogenetic role for acetylsalicylic acid, contraceptives and smoking?. Acta Derm Venereol. 1988;68(5):402-7. [Medline].
Man I, Ibbotson SH, Ferguson J. Photoinduced pompholyx: a report of 5 cases. J Am Acad Dermatol. Jan 2004;50(1):55-60. [Medline].
Man I, Ibbotson SH, Ferguson J. Photoinduced pompholyx: a report of 5 cases. J Am Acad Dermatol. Jan 2004;50(1):55-60. [Medline].
Guillet MH, Wierzbicka E, Guillet S, Dagregorio G, Guillet G. A 3-year causative study of pompholyx in 120 patients. Arch Dermatol. Dec 2007;143(12):1504-8. [Medline].
Uyttendaele H, Obadiah J, Grossman M. Dyshidrotic-like spongiotic dermatitis after intravenous immunoglobulin therapy. J Drugs Dermatol. Jun 2003;2(3):337-41. [Medline].
Colebunders R, Zolfo M, Lynen L. Severe dyshidrosis in two patients with HIV infection shortly after starting highly active antiretroviral treatment. Dermatol Online J. Aug 1 2005;11(2):31. [Medline].
MacConnachie AA, Smith CC. Pompholyx eczema as a manifestation of HIV infection, response to antiretroviral therapy. Acta Derm Venereol. 2007;87(4):378-9. [Medline].
Kim YJ, Kim MY, Kim HO, Park YM. Dyshidrosiform bullous pemphigoid. Acta Derm Venereol. 2004;84(3):253-4. [Medline].
Schnopp C, Remling R, Mohrenschlager M, Weigl L, Ring J, Abeck D. Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial. J Am Acad Dermatol. Jan 2002;46(1):73-7. [Medline].
Schurmeyer-Horst F, Luger TA, Bohm M. Long-term efficacy of occlusive therapy with topical pimecrolimus in severe dyshidrosiform hand and foot eczema. Dermatology. 2007;214(1):99-100. [Medline].
Egawa K. Topical vitamin D3 derivatives in treating hyperkeratotic palmoplantar eczema: a report of five patients. J Dermatol. May 2005;32(5):381-6. [Medline].
Scerri L. Azathioprine in dermatological practice. An overview with special emphasis on its use in non-bullous inflammatory dermatoses. Adv Exp Med Biol. 1999;455:343-8. [Medline].
Egan CA, Rallis TM, Meadows KP, Krueger GG. Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx. J Am Acad Dermatol. Apr 1999;40(4):612-4. [Medline].
Pickenacker A, Luger TA, Schwarz T. Dyshidrotic eczema treated with mycophenolate mofetil. Arch Dermatol. Mar 1998;134(3):378-9. [Medline].
Ogden S, Clayton TH, Goodfield MJ. Recalcitrant hand pompholyx: variable response to etanercept. Clin Exp Dermatol. Jan 2006;31(1):145-6. [Medline].
Behrens S, von Kobyletzki G, Gruss C, Reuther T, Altmeyer P, Kerscher M. PUVA-bath photochemotherapy (PUVA-soak therapy) of recalcitrant dermatoses of the palms and soles. Photodermatol Photoimmunol Photomed. Apr 1999;15(2):47-51. [Medline].
Petering H, Breuer C, Herbst R, Kapp A, Werfel T. Comparison of localized high-dose UVA1 irradiation versus topical cream psoralen-UVA for treatment of chronic vesicular dyshidrotic eczema. J Am Acad Dermatol. Jan 2004;50(1):68-72. [Medline].
Tzaneva S, Kittler H, Thallinger C, Honigsmann H, Tanew A. Oral vs. bath PUVA using 8-methoxypsoralen for chronic palmoplantar eczema. Photodermatol Photoimmunol Photomed. Apr 2009;25(2):101-5. [Medline].
Robertson L. New and existing therapeutic options for hand eczema. Skin Therapy Lett. Mar 2009;14(3):1-5. [Medline].
Swartling C, Naver H, Lindberg M, Anveden I. Treatment of dyshidrotic hand dermatitis with intradermal botulinum toxin. J Am Acad Dermatol. Nov 2002;47(5):667-71. [Medline].
Kontochristopoulos G, Gregoriou S, Agiasofitou E, Nikolakis G, Rigopoulos D, Katsambas A. Letter: regression of relapsing dyshidrotic eczema after treatment of concomitant hyperhidrosis with botulinum toxin-A. Dermatol Surg. Oct 2007;33(10):1289-90. [Medline].
Wollina U, Karamfilov T. Adjuvant botulinum toxin A in dyshidrotic hand eczema: a controlled prospective pilot study with left-right comparison. J Eur Acad Dermatol Venereol. Jan 2002;16(1):40-2. [Medline].
Fairris GM, Jones DH, Mack DP, Rowell NR. Conventional superficial X-ray versus Grenz ray therapy in the treatment of constitutional eczema of the hands. Br J Dermatol. Mar 1985;112(3):339-41. [Medline].
Cartwright PH, Rowell NR. Comparison of Grenz rays versus placebo in the treatment of chronic hand eczema. Br J Dermatol. Jul 1987;117(1):73-6. [Medline].
Lindelof B, Wrangsjo K, Liden S. A double-blind study of Grenz ray therapy in chronic eczema of the hands. Br J Dermatol. Jul 1987;117(1):77-80. [Medline].
Matin A, Bliwise DL, Wellman JJ, Ewing HA, Rasmuson P. Resolution of dyshidrotic dermatitis of the hand after treatment with continuous positive airway pressure for obstructive sleep apnea. South Med J. Feb 2002;95(2):253-4. [Medline].
Stuckert J, Nedorost S. Low-cobalt diet for dyshidrotic eczema patients. Contact Dermatitis. Dec 2008;59(6):361-5. [Medline].
Vocks E, Plotz SG, Ring J. The Dyshidrotic Eczema Area and Severity Index - A score developed for the assessment of dyshidrotic eczema. Dermatology. 1999;198(3):265-9. [Medline].
Burton JL, Holden CA. Morphological types of hand eczema, pompholyx. Eczema, lichenification and prurigo. In: Champion RH, Wilkinson DS, Ebling FJG, eds. Rook, Wilkinson, Ebling Textbook of Dermatology. 6th ed. Blackwell Science: 1998:650-2.
Douwes KE, Karrer S, Abels C, Landthaler M, Szeimies RM. Does smoking influence the efficacy of bath-PUVA therapy in chronic palmoplantar eczema?. Photodermatol Photoimmunol Photomed. Feb 2000;16(1):25-9. [Medline].
Kimball A. Vesicular palmoplantar eczema. In: Fitzpatrick's Dermatology in General Medicine. 2003.
Odia S, Vocks E, Rakoski J, Ring J. Successful treatment of dyshidrotic hand eczema using tap water iontophoresis with pulsed direct current. Acta Derm Venereol. Nov 1996;76(6):472-4. [Medline].
Schmidt T, Abeck D, Boeck K, Mempel M, Ring J. UVA1 irradiation is effective in treatment of chronic vesicular dyshidrotic hand eczema. Acta Derm Venereol. Jul 1998;78(4):318-9. [Medline].
Storrs FJ. Acute and recurrent vesicular hand dermatitis not pompholyx or dyshidrosis. Arch Dermatol. Dec 2007;143(12):1578-80. [Medline].
Sugimura C, Katsuura J, Moriue T, Matsuoka Y, Kubota Y. Dyshidrosiform pemphigoid: report of a case. J Dermatol. Jul 2003;30(7):525-9. [Medline].
Wilkinson JD. Vesicular palmoplantar eczema. In: Freedberg IM, Elsen AZ, Wolff K, eds. Fitzpatrick's Dermatology in General Medicine. 5th ed. McGraw-Hill; 1999:1489-94.
Further Reading
Keywords
vesicular palmoplantar eczema, pompholyx, dyshidrotic eczema, vesicobullous dermatitis, dyshidrosis, subacute vesiculosquamous eczema, chronic relapsing vesiculosquamous eczema, hand eczema
Follow-up: Vesicular Palmoplantar Eczema