eMedicine Specialties > Dermatology > Viral Infections
Epidermodysplasia Verruciformis: Multimedia
Updated: Nov 13, 2007
Multimedia
 | Media file 1: Eruptive, polymorphic, warty papules and plaques on the lower extremities of a patient with epidermodysplasia verruciformis. Courtesy of Professor S. Jablonska and Professor S. Majewski. |
 | Media file 2: Left: Photomicrograph of a precancerous, verrucous skin lesion from a patient with epidermodysplasia verruciformis depicts the characteristic microscopic features of specific cytopathic effect, that is, the presence of clear cells and an occasional enlarged, hyperchromatic, atypical nucleus (center of the field) in the epidermis. These changes are seen in human papillomavirus (HPV)-associated epithelial lesions (hematoxylin-eosin stain, original magnification X250). Right: Photomicrograph of the same skin lesion shows positive staining of keratinocytes infected with HPV type 8 (in situ hybridization, original magnification X250). Note darker, spherical-to-ovoid shaped positive nuclear staining. These are sites of HPV DNA. |
 | Media file 3: Large amounts of human papillomavirus (HPV) DNA are demonstrated by immunostaining a skin biopsy of a warty lesion of epidermodysplasia verruciformis. Note prominent vacuolation of the cytoplasm of the infected cells (koilocytosis), typical of lesions associated with HPV infection. The darker positive staining areas are the sites of HPV DNA (in situ hybridization, original magnification X450). |
 | Media file 4: A photomicrograph shows an invasive well-differentiated squamous cell carcinoma that arose in a warty lesion on sun-exposed skin of a middle-aged patient with epidermodysplasia verruciformis. Notice the atypical, neoplastic squamous cancer cells with irregular, hyperchromatic nuclei and an occasional bizarre mitotic figure (shown near the 12-o'clock position in this field) invading into the dermis. A moderate host lymphocytic inflammatory response is present within the tumor (hematoxylin-eosin stain, original magnification X300). Squamous cell carcinoma is the most common type of skin cancer found in patients with epidermodysplasia verruciformis. |
More on Epidermodysplasia Verruciformis |
| Overview: Epidermodysplasia Verruciformis |
| Differential Diagnoses & Workup: Epidermodysplasia Verruciformis |
| Treatment & Medication: Epidermodysplasia Verruciformis |
| Follow-up: Epidermodysplasia Verruciformis |
 Multimedia: Epidermodysplasia Verruciformis |
| References |
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References
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Further Reading
Keywords
EV, human papillomavirus, human papillomavirus infection, HPV, HPV infection, squamous cell carcinoma
