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Roseola Infantum Differential Diagnoses

  • Author: Christopher R Gorman, MD; Chief Editor: William D James, MD  more...
 
Updated: Jun 02, 2016
 
 

Diagnostic Considerations

Also consider the following:

In patients who are immunocompromised, many differential diagnoses, including viral, bacterial, fungal, and immunologic conditions, exist.

In 2005, Ward suggested testing for human herpesvirus (HHV)–6 and HHV-7 primary infection when serious neurological disease/encephalitis is temporally related to immunization, lest the condition be misdiagnosed as a vaccine reaction.[8, 9]

Differential Diagnoses

  • Meningococcemia

 
 
Contributor Information and Disclosures
Author

Christopher R Gorman, MD Avenues Dermatology, Private Practice

Christopher R Gorman, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Paul Krusinski, MD Director of Dermatology, Fletcher Allen Health Care; Professor, Department of Internal Medicine, University of Vermont College of Medicine

Paul Krusinski, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Franklin Flowers, MD Department of Dermatology, Professor Emeritus Affiliate Associate Professor of Pathology, University of Florida College of Medicine

Franklin Flowers, MD is a member of the following medical societies: American College of Mohs Surgery

Disclosure: Nothing to disclose.

Acknowledgements

Acknowledgments

Medscape Drugs & Diseases wishes to recognize Stephen W White, MD† for his original contributions to this article.

References
  1. Vinnard C, Barton T, Jerud E, Blumberg E. A report of human herpesvirus 6-associated encephalitis in a solid organ transplant recipient and a review of previously published cases. Liver Transpl. 2009 Oct. 15(10):1242-6. [Medline].

  2. Abdel Massih RC, Razonable RR. Human herpesvirus 6 infections after liver transplantation. World J Gastroenterol. 2009 Jun 7. 15(21):2561-9. [Medline]. [Full Text].

  3. Kittaka S, Hasegawa S, Ito Y, Ohbuchi N, Suzuki E, Kawano S, et al. Serum levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in human herpesvirus-6-infected infants with or without febrile seizures. J Infect Chemother. 2014 Nov. 20 (11):716-21. [Medline].

  4. Zerr DM, Meier AS, Selke SS, et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med. 2005 Feb 24. 352(8):768-76. [Medline].

  5. Vianna RA, de Oliveira SA, Camacho LA, et al. Role of human herpesvirus 6 infection in young Brazilian children with rash illnesses. Pediatr Infect Dis J. 2008 Jun. 27(6):533-7. [Medline].

  6. Magalhães Ide M, Martins RV, Vianna RO, Moysés N, Afonso LA, Oliveira SA, et al. Detection of human herpesvirus 7 infection in young children presenting with exanthema subitum. Mem Inst Oswaldo Cruz. 2011 May. 106(3):371-3. [Medline].

  7. Razonable RR, Lautenschlager I. Impact of human herpes virus 6 in liver transplantation. World J Hepatol. 2010 Sep 27. 2(9):345-53. [Medline]. [Full Text].

  8. Ward KN. The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent. J Clin Virol. 2005 Mar. 32(3):183-93. [Medline].

  9. Ward KN, Andrews NJ, Verity CM, Miller E, Ross EM. Human herpesviruses-6 and -7 each cause significant neurological morbidity in Britain and Ireland. Arch Dis Child. 2005 Jun. 90(6):619-23. [Medline].

  10. Higashimoto Y, Ohta A, Nishiyama Y, et al. Development of a human herpesvirus 6 species-specific immunoblotting assay. J Clin Microbiol. 2012 Apr. 50(4):1245-51. [Medline]. [Full Text].

  11. Stone RC, Micali GA, Schwartz RA. Roseola infantum and its causal human herpesviruses. Int J Dermatol. 2014 Apr. 53(4):397-403. [Medline].

  12. Rapaport D, Engelhard D, Tagger G, Or R, Frenkel N. Antiviral prophylaxis may prevent human herpesvirus-6 reactivation in bone marrow transplant recipients. Transpl Infect Dis. 2002 Mar. 4(1):10-6. [Medline].

 
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Roseola infantum. Image courtesy of Wikimedia Commons.
Roseola infantum. Image courtesy of Wikimedia Commons.
 
 
 
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