Human Herpesvirus 6 Medication

  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD   more...
 
Updated: Feb 27, 2012
 

Medication Summary

Although human herpesvirus 6 (HHV-6) is inhibited by several antiviral drugs in the laboratory (eg, GCV, foscarnet), no clinical trials have assessed their benefit. No seizure medication is indicated for febrile seizures. Antipyretics (eg, acetaminophen) can be given for high fever. Avoid aspirin in children because of the risk of Reye syndrome.

The effectiveness of ganciclovir was evaluated against HHV-6 excreted in saliva in stem cell transplant recipients.[29] Ganciclovir can decrease the HHV-6 viral load in saliva.

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Antipyretics

Class Summary

These agents are indicated for an excessively high fever.

View full drug information

Acetaminophen (Tylenol, FeverAll, Anacin-Free Aspirin)

 

Reduces fever by acting directly on hypothalamic heat-regulating centers, which increases dissipation of body heat via vasodilation and sweating.

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Contributor Information and Disclosures
Author

Robert A Schwartz, MD, MPH  Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and Sigma Xi

Disclosure: Nothing to disclose.

Coauthor(s)

Cris Jagar  MD, Staff Physician, Department of Psychiatry, Trinitas Regional Medical Center

Disclosure: Nothing to disclose.

Ewa Koziorynska, MD  Assistant Professor of Neurology, Comprehensive Epilepsy Center, State University of New York Downstate Medical Center

Ewa Koziorynska, MD is a member of the following medical societies: Sigma Xi

Disclosure: none None None

Specialty Editor Board

Franklin Flowers, MD  Chief, Division of Dermatology, Professor, Department of Medicine and Otolaryngology, Affiliate Associate Professor of Pediatrics and Pathology, University of Florida College of Medicine

Franklin Flowers, MD, is a member of the following medical societies: American College of Mohs Micrographic Surgery and Cutaneous Oncology

Disclosure: Nothing to disclose.

David F Butler, MD  Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Jeffrey Meffert, MD  Assistant Clinical Professor of Dermatology, University of Texas School of Medicine at San Antonio

Jeffrey Meffert, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Association of Military Dermatologists, and Texas Dermatological Society

Disclosure: Nothing to disclose.

Glen H Crawford, MD  Assistant Clinical Professor, Department of Dermatology, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, The Pennsylvania Hospital

Glen H Crawford, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Phi Beta Kappa, and Society of USAF Flight Surgeons

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD  Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology and Society for Investigative Dermatology

Disclosure: Elsevier Royalty Other

References

  1. Rantala H, Mannonen L, Ahtiluoto S, et al. Human herpesvirus-6 associated encephalitis with subsequent infantile spasms and cerebellar astrocytoma. Dev Med Child Neurol. Jun 2000;42(6):418-21. [Medline].

  2. De Almeida Rodrigues G, Nagendra S, Lee CK, De Magalhaes-Silverman M. Human herpes virus 6 fatal encephalitis in a bone marrow recipient. Scand J Infect Dis. 1999;31(3):313-5. [Medline].

  3. Mendez JC, Dockrell DH, Espy MJ, et al. Human beta-herpesvirus interactions in solid organ transplant recipients. J Infect Dis. Jan 15 2001;183(2):179-184. [Medline].

  4. Isegawa Y, Katahira J, Yamanishi K, Sugimoto N. Reactivation of latent human immunodeficiency virus 1 by human herpesvirus 6 infection. Acta Virol. 2007;51(1):13-20. [Medline].

  5. Broccolo F, Drago F, Careddu AM, et al. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. J Invest Dermatol. Jun 2005;124(6):1234-40. [Medline].

  6. Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, Beneton N, Jidar K, Barbaud A, et al. Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro. Eur J Dermatol. Jan-Feb 2010;20(1):68-73. [Medline].

  7. Peppercorn AF, Miller MB, Fitzgerald D, Weber DJ, Groben PA, Cairns BA. High-level human herpesvirus-6 viremia associated with onset of Stevens-Johnson syndrome: report of two cases. J Burn Care Res. Mar-Apr 2010;31(2):365-8. [Medline].

  8. Zerr DM, Meier AS, Selke SS, et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med. Feb 24 2005;352(8):768-76. [Medline].

  9. Kumagai T, Yoshikawa T, Yoshida M, et al. Time course characteristics of human herpesvirus 6 specific cellular immune response and natural killer cell activity in patients with exanthema subitum. J Med Virol. Jun 2006;78(6):792-9. [Medline].

  10. Ward KN, Leong HN, Nacheva EP, et al. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J Clin Microbiol. Apr 2006;44(4):1571-4. [Medline].

  11. Bates M, Monze M, Bima H, et al. Predominant human herpesvirus 6 variant A infant infections in an HIV-1 endemic region of Sub-Saharan Africa. J Med Virol. May 2009;81(5):779-89. [Medline].

  12. Magalhaes IM, Martins RV, Cossatis JJ, et al. Detection of human herpesvirus 6 and 7 DNA in saliva from healthy adults from Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. Nov 2010;105(7):925-7. [Medline].

  13. Lautenschlager I, Razonable RR. Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review. Transpl Int. Feb 23 2012;[Medline].

  14. Eshki M, Allanore L, Musette P, et al. Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. Arch Dermatol. Jan 2009;145(1):67-72. [Medline].

  15. Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, et al. The DRESS syndrome: a literature review. Am J Med. Jul 2011;124(7):588-97. [Medline].

  16. Watanabe T, Nakashima H, Ohmatsu H, Sakurai N, Takekoshi T, Tamaki K. Detection of human herpesvirus-6 transcripts in carbamazepine-induced hypersensitivity syndrome by in situ hybridization. J Dermatol Sci. May 2009;54(2):134-6. [Medline].

  17. Sato T, Kuniba H, Matsuo M, Matsuzaka T, Moriuchi H. [A case of drug-induced hypersensitivity syndrome due to lamotrigine: demonstration of sequential reactivation of herpesviruses]. No To Hattatsu. Jan 2012;44(1):69-72. [Medline].

  18. Morimoto M, Watanabe Y, Arisaka T, et al. A case of drug-induced hypersensitivity syndrome due to carbamazepine. Bull Tokyo Dent Coll. 2011;52(3):135-42. [Medline].

  19. Watanabe H. Hypersensitivity syndrome due to trichloroethylene exposure: a severe generalized skin reaction resembling drug-induced hypersensitivity syndrome. J Dermatol. Mar 2011;38(3):229-35. [Medline].

  20. Corti M, Villafañe MF, Trione N, Mamanna L, Bouzas B. Human herpesvirus 6: report of emerging pathogen in five patients with HIV/AIDS and review of the literature. Rev Soc Bras Med Trop. Jul-Aug 2011;44(4):522-5. [Medline].

  21. Fujiwara N, Namba H, Ohuchi R, et al. Monitoring of human herpesvirus-6 and -7 genomes in saliva samples of healthy adults by competitive quantitative PCR. J Med Virol. Jun 2000;61(2):208-13. [Medline].

  22. Norton RA, Caserta MT, Hall CB, Schnabel K, Hocknell P, Dewhurst S. Detection of human herpesvirus 6 by reverse transcription-PCR. J Clin Microbiol. Nov 1999;37(11):3672-5. [Medline].

  23. Sanders VJ, Felisan S, Waddell A, Tourtellotte WW. Detection of herpesviridae in postmortem multiple sclerosis brain tissue and controls by polymerase chain reaction. J Neurovirol. Aug 1996;2(4):249-58. [Medline].

  24. Caserta MT, Hall CB, Schnabel K, Lofthus G, Marino A, Shelley L, et al. Diagnostic assays for active infection with human herpesvirus 6 (HHV-6). J Clin Virol. May 2010;48(1):55-7. [Medline]. [Full Text].

  25. Harma M, Hockerstedt K, Lyytikainen O, Lautenschlager I. HHV-6 and HHV-7 antigenemia related to CMV infection after liver transplantation. J Med Virol. Jun 2006;78(6):800-5. [Medline].

  26. Engelmann I, Petzold DR, Kosinska A, Hepkema BG, Schulz TF, Heim A. Rapid quantitative PCR assays for the simultaneous detection of herpes simplex virus, varicella zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6 DNA in blood and other clinical specimens. J Med Virol. Mar 2008;80(3):467-77. [Medline].

  27. Galarraga MC, Gomez E, de Ona M, et al. Influence of ganciclovir prophylaxis on citomegalovirus, human herpesvirus 6, and human herpesvirus 7 viremia in renal transplant recipients. Transplant Proc. Jun 2005;37(5):2124-6. [Medline].

  28. Drago F, Vecchio F, Rebora A. Use of high-dose acyclovir in pityriasis rosea. J Am Acad Dermatol. Jan 2006;54(1):82-5. [Medline].

  29. Ljungman P, Dahl H, Xu YH, Larsson K, Brytting M, Linde A. Effectiveness of ganciclovir against human herpesvirus-6 excreted in saliva in stem cell transplant recipients. Bone Marrow Transplant. Apr 2007;39(8):497-9. [Medline].

  30. Cuende JI, Civeira P, Diez N, Prieto J. [High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome]. An Med Interna. Sep 1997;14(9):441-4. [Medline].

  31. Weber T, Theurich S, Christopeit M, Klapperstueck T, Behre G. Human herpesvirus-6 as an inducer of porphyria cutanea tarda: implications from a case. Transpl Infect Dis. May 7 2010;[Medline].

  32. Altschuler EL. Oldest description of roseola and implications for the antiquity of human herpesvirus 6. Pediatr Infect Dis J. Sep 2000;19(9):903. [Medline].

  33. Asano Y, Yoshikawa T, Suga S, et al. Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). Pediatrics. Jan 1994;93(1):104-8. [Medline].

  34. Baillargeon J, Piper J, Leach CT. Epidemiology of human herpesvirus 6 (HHV-6) infection in pregnant and nonpregnant women. J Clin Virol. May 2000;16(3):149-57. [Medline].

  35. Clark DA. Human herpesvirus 6. Rev Med Virol. May-Jun 2000;10(3):155-73. [Medline].

  36. Dockrell DH, Smith TF, Paya CV. Human herpesvirus 6. Mayo Clin Proc. Feb 1999;74(2):163-70. [Medline].

  37. Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med. Aug 18 1994;331(7):432-8. [Medline].

  38. Josephs SF, Salahuddin SZ, Ablashi DV, Schachter F, Wong-Staal F, Gallo RC. Genomic analysis of the human B-lymphotropic virus (HBLV). Science. Oct 31 1986;234(4776):601-3. [Medline].

  39. Kitamura K, Asada H, Iida H, et al. Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation. J Am Acad Dermatol. May 2008;58(5):802-9. [Medline].

  40. Kosuge H. HHV-6, 7 and their related diseases. J Dermatol Sci. Apr 2000;22(3):205-12. [Medline].

  41. Leach CT. Human herpesvirus-6 and -7 infections in children: agents of roseola and other syndromes. Curr Opin Pediatr. Jun 2000;12(3):269-74. [Medline].

  42. Morimoto T, Sato T, Matsuoka A, et al. Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6. Intern Med. 2006;45(2):101-5. [Medline].

  43. Pereira CM, de Almeida OP, Correa ME, et al. Detection of human herpesvirus 6 in patients with oral chronic graft-vs-host disease following allogeneic progenitor cell transplantation. Oral Dis. May 2007;13(3):329-34. [Medline].

  44. Ranger-Rogez S, Venot C, Denis F. [Human herpesviruses 6 and 7 (HHV-6 and HHV-7)]. Rev Prat. Dec 15 1999;49(20):2227-31. [Medline].

  45. Stoeckle MY. The spectrum of human herpesvirus 6 infection: from roseola infantum to adult disease. Annu Rev Med. 2000;51:423-30. [Medline].

  46. Teach SJ, Wallace HL, Evans MJ, Duffner PK, Hay J, Faden HS. Human herpesviruses types 6 and 7 and febrile seizures. Pediatr Neurol. Oct 1999;21(4):699-703. [Medline].

  47. Teraki Y, Murota H, Izaki S. Toxic epidermal necrolysis due to zonisamide associated with reactivation of human herpesvirus 6. Arch Dermatol. Feb 2008;144(2):232-5. [Medline].

  48. Tung Y, Escutia B, Blanes M, Navarrro M, Pujol C. Sulfasalazine-Induced Hypersensitivity Syndrome Associated With Human Herpesvirus 6 Reactivation and Induction of Antiphospholipid Syndrome. Actas Dermosifiliogr. Mar 22 2011;[Medline].

  49. Yoshikawa T, Asano Y. Central nervous system complications in human herpesvirus-6 infection. Brain Dev. Aug 2000;22(5):307-14. [Medline].

  50. Yoshikawa T, Black JB, Ihira M, et al. Comparison of specific serological assays for diagnosing human herpesvirus 6 infection after liver transplantation. Clin Diagn Lab Immunol. Jan 2001;8(1):170-3. [Medline].

 
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