eMedicine Specialties > Neurology > Behavioral Neurology and Dementia
Alzheimer Disease: Follow-up
Updated: Aug 27, 2009
Follow-up
Deterrence/Prevention
Although previous reports reflect delayed onset of Alzheimer disease (AD) in individuals who used nonsteroidal anti-inflammatory drugs (NSAIDs), a study by Breitner et al showed NSAIDs do not protect against AD, at least in very old people. Relying on computerized pharmacy dispensing records and biennial dementia screening, investigators found Alzheimer disease incidence was increased in heavy NSAID users. These findings may represent deferral of Alzheimer disease symptoms from earlier to later old age.24Patient Education
For excellent patient education resources, visit eMedicine's Dementia Center. Also, see eMedicine's patient education articles Alzheimer Disease, Alzheimer Disease in Individuals With Down Syndrome, Dementia Overview, and Dementia Medication Overview.
Miscellaneous
Medicolegal Pitfalls
- Patients with dementia, in general, and those with Alzheimer disease, in particular, usually have a progressive deterioration in their behavior, cognition, and ability to perform activities of daily living.
- These changes may result in patients making inappropriate or adverse psychosocial decisions, such as the mismanagement of funds or serious lapses in their family, social, and occupational responsibilities.
- Medical advice should include a warning about these possibilities, given to both the patient and to their caregivers (at least those most directly responsible for the patient's care) to minimize the risk of adverse legal effects on the patient or others.
- Particular attention should be given to the need to make a legal statement about the patient's competency to handle his or her affairs and about assigning power of attorney for the patient's estate and other matters. These delicate decisions must be individualized and coupled with an attorney's advice.
The authors and editors of eMedicine gratefully acknowledge the contributions of previous author Rodrigo O Kuljis, MD to the development and writing of this article.
More on Alzheimer Disease |
| Overview: Alzheimer Disease |
| Differential Diagnoses & Workup: Alzheimer Disease |
| Treatment & Medication: Alzheimer Disease |
Follow-up: Alzheimer Disease |
| References |
| « Previous Page |
References
Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1-2):125-32. [Medline].
Wimo, A; Winblad, B; Jonsson, L. An estimate of the total worldwide societal costs of dementia in 2005. Alzheimer's & Dementia. 2007;3:81-91.
Hebert LE, Scherr PA, Bienias JL, et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. Aug 2003;60(8):1119-22. [Medline].
Alzheimer A. Uber eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiat. 1907;64:146-8.
Braak H, Braak E, Grundke-Iqbal I, et al. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett. Apr 24 1986;65(3):351-5. [Medline].
Fitzpatrick AL, Kuller LH, Ives DG, et al. Incidence and prevalence of dementia in the Cardiovascular Health Study. J Am Geriatr Soc. Feb 2004;52(2):195-204. [Medline].
Evans DA, Bennett DA, Wilson RS, et al. Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol. Feb 2003;60(2):185-9. [Medline].
Shadlen MF, Siscovick D, Fitzpatrick AL, et al. Education, cognitive test scores, and black-white differences in dementia risk. J Am Geriatr Soc. Jun 2006;54(6):898-905. [Medline].
Tang MX, Cross P, Andrews H, et al. Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan. Neurology. Jan 9 2001;56(1):49-56. [Medline].
Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C. Age, neuropathology, and dementia. N Engl J Med. May 28 2009;360(22):2302-9. [Medline].
Cechetto DF, Hachinski V, Whitehead SN. Vascular risk factors and Alzheimer's disease. Expert Rev Neurother. May 2008;8(5):743-50. [Medline].
Razay G, Vreugdenhil A, Wilcock G. The metabolic syndrome and Alzheimer disease. Arch Neurol. Jan 2007;64(1):93-6. [Medline].
Swerdlow RH, Khan SM. A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease. Med Hypotheses. 2004;63(1):8-20. [Medline].
Swerdlow RH. Pathogenesis of Alzheimer's disease. Clin Interv Aging. 2007;2(3):347-59. [Medline].
Lee HG, Zhu X, Castellani RJ, et al. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. J Pharmacol Exp Ther. Jun 2007;321(3):823-9. [Medline].
[Best Evidence] Green RC, Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Brown T, et al. Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med. Jul 16 2009;361(3):245-54. [Medline].
Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. Oct 2004;85(10):1694-704. [Medline].
Friedland RP, Fritsch T, Smyth KA, et al. Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members. Proc Natl Acad Sci U S A. Mar 13 2001;98(6):3440-5. [Medline].
[Best Evidence] Doody RS, Ferris SH, Salloway S, Sun Y, Goldman R, Watkins WE, et al. Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology. May 5 2009;72(18):1555-61. [Medline].
Starr JM. Cholinesterase inhibitor treatment and urinary incontinence in Alzheimer's disease. J Am Geriatr Soc. May 2007;55(5):800-1. [Medline].
[Best Evidence] Gill SS, Anderson GM, Fischer HD, Bell CM, Li P, Normand SL, et al. Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study. Arch Intern Med. May 11 2009;169(9):867-73. [Medline].
Schmitt FA, van Dyck CH, Wichems CH, et al. Cognitive response to memantine in moderate to severe Alzheimer disease patients already receiving donepezil: an exploratory reanalysis. Alzheimer Dis Assoc Disord. Oct-Dec 2006;20(4):255-62. [Medline].
Porsteinsson AP, Grossberg GT, Mintzer J, et al. Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial. Curr Alzheimer Res. Feb 2008;5(1):83-9. [Medline].
Breitner JC, Haneuse S, Walker R, Dublin S, Crane PK, Gray SL, et al. Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology. Jun 2 2009;72(22):1899-1905.
Alzheimer A. Uber eine eigenartige Erkankung der Hirnrinde. Allg Z Psychiatr. 1907;64:146.
Braak H, Braak E. Ratio of pyramidal cells versus non-pyramidal cells in the human frontal isocortex and changes in ratio with ageing and Alzheimer's disease. Prog Brain Res. 1986;70:185-212. [Medline].
Crook R, Verkkoniemi A, Perez-Tur J, et al. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nat Med. Apr 1998;4(4):452-5. [Medline].
Crystal HA, Horoupian DS, Katzman R, et al. Biopsy-proved Alzheimer disease presenting as a right parietal lobe syndrome. Ann Neurol. Aug 1982;12(2):186-8. [Medline].
Du Y, Dodel R, Hampel H, et al. Reduced levels of amyloid beta-peptide antibody in Alzheimer disease. Neurology. Sep 11 2001;57(5):801-5. [Medline].
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. Nov 1975;12(3):189-98. [Medline].
Frisoni GB, Padovani A, Wahlund LO. The diagnosis of Alzheimer disease before it is Alzheimer dementia. Arch Neurol. Jul 2003;60(7):1023; author reply 1023-4. [Medline].
Gilman S, Koller M, Black RS, et al. Clinical effects of A{beta} immunization (AN1792) in patients with AD in an interrupted trial. Neurology. Apr 7 2005.
Hamdy RC. Alzheimer's disease: an overview. South Med J. Jul 2001;94(7):661-2. [Medline].
Hof PR, Morrison JH. The cellular basis of cortical disconnection in Alzheimer's disease and related dementing conditions. In: Terry RD, Katzman R, Bick KL, eds. Alzheimer's Disease. New York: Lippincott Raven; 1994:197-229.
Irizarry MC, Hyman BT. Alzheimer disease therapeutics. J Neuropathol Exp Neurol. Oct 2001;60(10):923-8. [Medline].
Jönsson L, Jonsson B, Wimo A, et al. Second International Pharmacoeconomic Conference on Alzheimer' s Disease. Alzheimer Dis Assoc Disord. Jul-Sep 2000;14(3):137-40. [Medline].
Katzman R. Alzheimer's disease. N Engl J Med. Apr 10 1986;314(15):964-73. [Medline].
Kuljis RO. Modular corticocerebral pathology in Alzheimer's disease. In: Mangone CA, Allegri RF, Ariza, eds. Dementia: A Multidisciplinary Approach. 1997:143-55.
Kuljis RO. Lesions in the pulvinar in patients with Alzheimer's disease. J Neuropathol Exp Neurol. Mar 1994;53(2):202-11. [Medline].
Maelicke A, Albuquerque EX. Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease. Eur J Pharmacol. Mar 30 2000;393(1-3):165-70. [Medline].
Mayeux R, Sano M. Treatment of Alzheimer's disease. N Engl J Med. Nov 25 1999;341(22):1670-9. [Medline].
McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. Jul 1984;34(7):939-44. [Medline].
Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. Apr 1991;41(4):479-86. [Medline].
Moretti R, Torre P, Antonello RM, et al. Gabapentin as a possible treatment of behavioral alterations in Alzheimer disease (AD) patients. Eur J Neurol. Sep 2001;8(5):501-2. [Medline].
Raskind MA, Peskind ER, Wessel T, et al. Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group. Neurology. Jun 27 2000;54(12):2261-8. [Medline].
Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry. Nov 1984;141(11):1356-64. [Medline].
Selkoe DJ. Treating Alzheimer's disease: a new era begins. Neurol Alert. 2000;18:81-2.
Slagle MA. Featured CME topic: dementia. Medication update. South Med J. Jul 2001;94(7):678-81. [Medline].
Talesa VN. Acetylcholinesterase in Alzheimer's disease. Mech Ageing Dev. Nov 2001;122(16):1961-9. [Medline].
Tariot PN, Solomon PR, Morris JC, et al. A 5-month, randomized, placebo-controlled trial of galantamine in AD. The Galantamine USA-10 Study Group. Neurology. Jun 27 2000;54(12):2269-76. [Medline].
Tomlinson BE. Ageing and the dementias. In: Hume Adams J, Duchen LW, eds. Greenfield's Neuropathology. New York: Oxford Press; 1992:1284-410.
Verkkoniemi A, Somer M, Rinne JO, et al. Variant Alzheimer's disease with spastic paraparesis: clinical characterization. Neurology. Mar 14 2000;54(5):1103-9. [Medline].
von Gunten A, Kovari E, Rivara CB, et al. Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: evidence for sparing of the entorhinal cortex and CA1 field. Exp Neurol. May 2005;193(1):198-206. [Medline].
Further Reading
Keywords
Alzheimer’s disease, dementia, cognitive impairment, Alzheimer's disease signs and symptoms, Alzheimer's disease treatment, senile dementia of the Alzheimer type, Alzheimer dementia, Alzheimer's dementia, AD, primary neuronal degeneration, senile plaques, SP, neurofibrillary tangles, NFT, cerebrocortical atrophy, central nervous system, CNS, acetylcholine, acetylcholinesterase, butyrylcholinesterase, NMDA, memantine
Follow-up: Alzheimer Disease