eMedicine Specialties > Neurology > Behavioral Neurology and Dementia

Alzheimer Disease: Follow-up

Author: Heather S Anderson, MD, Assistant Professor, Staff Neurologist, Department of Neurology, Alzheimer and Memory Center, University of Kansas Medical Center
Contributor Information and Disclosures

Updated: Aug 27, 2009

Follow-up

Deterrence/Prevention

Although previous reports reflect delayed onset of Alzheimer disease (AD) in individuals who used nonsteroidal anti-inflammatory drugs (NSAIDs), a study by Breitner et al showed NSAIDs do not protect against AD, at least in very old people. Relying on computerized pharmacy dispensing records and biennial dementia screening, investigators found Alzheimer disease incidence was increased in heavy NSAID users. These findings may represent deferral of Alzheimer disease symptoms from earlier to later old age.24

Patient Education

For excellent patient education resources, visit eMedicine's Dementia Center. Also, see eMedicine's patient education articles Alzheimer Disease, Alzheimer Disease in Individuals With Down Syndrome, Dementia Overview, and Dementia Medication Overview.

Miscellaneous

Medicolegal Pitfalls

  • Patients with dementia, in general, and those with Alzheimer disease, in particular, usually have a progressive deterioration in their behavior, cognition, and ability to perform activities of daily living.
    • These changes may result in patients making inappropriate or adverse psychosocial decisions, such as the mismanagement of funds or serious lapses in their family, social, and occupational responsibilities.
    • Medical advice should include a warning about these possibilities, given to both the patient and to their caregivers (at least those most directly responsible for the patient's care) to minimize the risk of adverse legal effects on the patient or others.
  • Particular attention should be given to the need to make a legal statement about the patient's competency to handle his or her affairs and about assigning power of attorney for the patient's estate and other matters. These delicate decisions must be individualized and coupled with an attorney's advice.
 
Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous author Rodrigo O Kuljis, MD to the development and writing of this article.



More on Alzheimer Disease

Overview: Alzheimer Disease
Differential Diagnoses & Workup: Alzheimer Disease
Treatment & Medication: Alzheimer Disease
Follow-up: Alzheimer Disease
References

References

  1. Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1-2):125-32. [Medline].

  2. Wimo, A; Winblad, B; Jonsson, L. An estimate of the total worldwide societal costs of dementia in 2005. Alzheimer's & Dementia. 2007;3:81-91.

  3. Hebert LE, Scherr PA, Bienias JL, et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. Aug 2003;60(8):1119-22. [Medline].

  4. Alzheimer A. Uber eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiat. 1907;64:146-8.

  5. Braak H, Braak E, Grundke-Iqbal I, et al. Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett. Apr 24 1986;65(3):351-5. [Medline].

  6. Fitzpatrick AL, Kuller LH, Ives DG, et al. Incidence and prevalence of dementia in the Cardiovascular Health Study. J Am Geriatr Soc. Feb 2004;52(2):195-204. [Medline].

  7. Evans DA, Bennett DA, Wilson RS, et al. Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol. Feb 2003;60(2):185-9. [Medline].

  8. Shadlen MF, Siscovick D, Fitzpatrick AL, et al. Education, cognitive test scores, and black-white differences in dementia risk. J Am Geriatr Soc. Jun 2006;54(6):898-905. [Medline].

  9. Tang MX, Cross P, Andrews H, et al. Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan. Neurology. Jan 9 2001;56(1):49-56. [Medline].

  10. Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C. Age, neuropathology, and dementia. N Engl J Med. May 28 2009;360(22):2302-9. [Medline].

  11. Cechetto DF, Hachinski V, Whitehead SN. Vascular risk factors and Alzheimer's disease. Expert Rev Neurother. May 2008;8(5):743-50. [Medline].

  12. Razay G, Vreugdenhil A, Wilcock G. The metabolic syndrome and Alzheimer disease. Arch Neurol. Jan 2007;64(1):93-6. [Medline].

  13. Swerdlow RH, Khan SM. A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease. Med Hypotheses. 2004;63(1):8-20. [Medline].

  14. Swerdlow RH. Pathogenesis of Alzheimer's disease. Clin Interv Aging. 2007;2(3):347-59. [Medline].

  15. Lee HG, Zhu X, Castellani RJ, et al. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. J Pharmacol Exp Ther. Jun 2007;321(3):823-9. [Medline].

  16. [Best Evidence] Green RC, Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Brown T, et al. Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med. Jul 16 2009;361(3):245-54. [Medline].

  17. Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. Oct 2004;85(10):1694-704. [Medline].

  18. Friedland RP, Fritsch T, Smyth KA, et al. Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members. Proc Natl Acad Sci U S A. Mar 13 2001;98(6):3440-5. [Medline].

  19. [Best Evidence] Doody RS, Ferris SH, Salloway S, Sun Y, Goldman R, Watkins WE, et al. Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology. May 5 2009;72(18):1555-61. [Medline].

  20. Starr JM. Cholinesterase inhibitor treatment and urinary incontinence in Alzheimer's disease. J Am Geriatr Soc. May 2007;55(5):800-1. [Medline].

  21. [Best Evidence] Gill SS, Anderson GM, Fischer HD, Bell CM, Li P, Normand SL, et al. Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study. Arch Intern Med. May 11 2009;169(9):867-73. [Medline].

  22. Schmitt FA, van Dyck CH, Wichems CH, et al. Cognitive response to memantine in moderate to severe Alzheimer disease patients already receiving donepezil: an exploratory reanalysis. Alzheimer Dis Assoc Disord. Oct-Dec 2006;20(4):255-62. [Medline].

  23. Porsteinsson AP, Grossberg GT, Mintzer J, et al. Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial. Curr Alzheimer Res. Feb 2008;5(1):83-9. [Medline].

  24. Breitner JC, Haneuse S, Walker R, Dublin S, Crane PK, Gray SL, et al. Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology. Jun 2 2009;72(22):1899-1905.

  25. Alzheimer A. Uber eine eigenartige Erkankung der Hirnrinde. Allg Z Psychiatr. 1907;64:146.

  26. Braak H, Braak E. Ratio of pyramidal cells versus non-pyramidal cells in the human frontal isocortex and changes in ratio with ageing and Alzheimer's disease. Prog Brain Res. 1986;70:185-212. [Medline].

  27. Crook R, Verkkoniemi A, Perez-Tur J, et al. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nat Med. Apr 1998;4(4):452-5. [Medline].

  28. Crystal HA, Horoupian DS, Katzman R, et al. Biopsy-proved Alzheimer disease presenting as a right parietal lobe syndrome. Ann Neurol. Aug 1982;12(2):186-8. [Medline].

  29. Du Y, Dodel R, Hampel H, et al. Reduced levels of amyloid beta-peptide antibody in Alzheimer disease. Neurology. Sep 11 2001;57(5):801-5. [Medline].

  30. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. Nov 1975;12(3):189-98. [Medline].

  31. Frisoni GB, Padovani A, Wahlund LO. The diagnosis of Alzheimer disease before it is Alzheimer dementia. Arch Neurol. Jul 2003;60(7):1023; author reply 1023-4. [Medline].

  32. Gilman S, Koller M, Black RS, et al. Clinical effects of A{beta} immunization (AN1792) in patients with AD in an interrupted trial. Neurology. Apr 7 2005.

  33. Hamdy RC. Alzheimer's disease: an overview. South Med J. Jul 2001;94(7):661-2. [Medline].

  34. Hof PR, Morrison JH. The cellular basis of cortical disconnection in Alzheimer's disease and related dementing conditions. In: Terry RD, Katzman R, Bick KL, eds. Alzheimer's Disease. New York: Lippincott Raven; 1994:197-229.

  35. Irizarry MC, Hyman BT. Alzheimer disease therapeutics. J Neuropathol Exp Neurol. Oct 2001;60(10):923-8. [Medline].

  36. Jönsson L, Jonsson B, Wimo A, et al. Second International Pharmacoeconomic Conference on Alzheimer' s Disease. Alzheimer Dis Assoc Disord. Jul-Sep 2000;14(3):137-40. [Medline].

  37. Katzman R. Alzheimer's disease. N Engl J Med. Apr 10 1986;314(15):964-73. [Medline].

  38. Kuljis RO. Modular corticocerebral pathology in Alzheimer's disease. In: Mangone CA, Allegri RF, Ariza, eds. Dementia: A Multidisciplinary Approach. 1997:143-55.

  39. Kuljis RO. Lesions in the pulvinar in patients with Alzheimer's disease. J Neuropathol Exp Neurol. Mar 1994;53(2):202-11. [Medline].

  40. Maelicke A, Albuquerque EX. Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease. Eur J Pharmacol. Mar 30 2000;393(1-3):165-70. [Medline].

  41. Mayeux R, Sano M. Treatment of Alzheimer's disease. N Engl J Med. Nov 25 1999;341(22):1670-9. [Medline].

  42. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. Jul 1984;34(7):939-44. [Medline].

  43. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. Apr 1991;41(4):479-86. [Medline].

  44. Moretti R, Torre P, Antonello RM, et al. Gabapentin as a possible treatment of behavioral alterations in Alzheimer disease (AD) patients. Eur J Neurol. Sep 2001;8(5):501-2. [Medline].

  45. Raskind MA, Peskind ER, Wessel T, et al. Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group. Neurology. Jun 27 2000;54(12):2261-8. [Medline].

  46. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry. Nov 1984;141(11):1356-64. [Medline].

  47. Selkoe DJ. Treating Alzheimer's disease: a new era begins. Neurol Alert. 2000;18:81-2.

  48. Slagle MA. Featured CME topic: dementia. Medication update. South Med J. Jul 2001;94(7):678-81. [Medline].

  49. Talesa VN. Acetylcholinesterase in Alzheimer's disease. Mech Ageing Dev. Nov 2001;122(16):1961-9. [Medline].

  50. Tariot PN, Solomon PR, Morris JC, et al. A 5-month, randomized, placebo-controlled trial of galantamine in AD. The Galantamine USA-10 Study Group. Neurology. Jun 27 2000;54(12):2269-76. [Medline].

  51. Tomlinson BE. Ageing and the dementias. In: Hume Adams J, Duchen LW, eds. Greenfield's Neuropathology. New York: Oxford Press; 1992:1284-410.

  52. Verkkoniemi A, Somer M, Rinne JO, et al. Variant Alzheimer's disease with spastic paraparesis: clinical characterization. Neurology. Mar 14 2000;54(5):1103-9. [Medline].

  53. von Gunten A, Kovari E, Rivara CB, et al. Stereologic analysis of hippocampal Alzheimer's disease pathology in the oldest-old: evidence for sparing of the entorhinal cortex and CA1 field. Exp Neurol. May 2005;193(1):198-206. [Medline].

Further Reading

Keywords

Alzheimer’s disease, dementia, cognitive impairment, Alzheimer's disease signs and symptoms, Alzheimer's disease treatment, senile dementia of the Alzheimer type, Alzheimer dementia, Alzheimer's dementia, AD, primary neuronal degeneration, senile plaques, SP, neurofibrillary tangles, NFT, cerebrocortical atrophy, central nervous system, CNS, acetylcholine, acetylcholinesterase, butyrylcholinesterase, NMDA, memantine

Contributor Information and Disclosures

Author

Heather S Anderson, MD, Assistant Professor, Staff Neurologist, Department of Neurology, Alzheimer and Memory Center, University of Kansas Medical Center
Heather S Anderson, MD is a member of the following medical societies: American Academy of Neurology
Disclosure: Central Plains Geriatric Education Center Honoraria Speaking and teaching

Medical Editor

Joseph Quinn, MD, Assistant Professor, Department of Neurology, Portland VA Medical Center, Oregon Health Sciences University
Joseph Quinn, MD is a member of the following medical societies: American Academy of Neurology, Society for Neuroscience, and Society for Pediatric Radiology
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

Richard J Caselli, MD, Professor, Department of Neurology, Mayo Medical School, Rochester, MN; Chair, Department of Neurology, Mayo Clinic of Scottsdale
Richard J Caselli, MD is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American Medical Association, American Neurological Association, and Sigma Xi
Disclosure: Nothing to disclose.

CME Editor

Selim R Benbadis, MD, Professor, Director of Comprehensive Epilepsy Program, Departments of Neurology and Neurosurgery, University of South Florida School of Medicine, Tampa General Hospital
Selim R Benbadis, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Sleep Medicine, American Clinical Neurophysiology Society, American Epilepsy Society, and American Medical Association
Disclosure: Nothing to disclose.

Chief Editor

Howard A Crystal, MD, Professor, Departments of Neurology and Pathology, State University of New York Downstate; Consulting Staff, Department of Neurology, University Hospital and Kings County Hospital Center
Howard A Crystal, MD is a member of the following medical societies: American Academy of Neurology and American Neurological Association
Disclosure: Medivations Honoraria Consulting

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.