Frontotemporal Lobe Dementia: Multimedia

References

1. Pick A. On the relationship between aphasia and senile atrophy of the brain. In: Rottenbergb DA, Hochberg FH, eds. Neurological Classics in Modern Translation. 39(5). Hafner Press; 1977.

2. Mesulam MM. Slowly progressive aphasia without generalized dementia. Ann Neurol. Jun 1982;11(6):592-8. [Medline].

3. Kirshner HS, Webb WG, Kelly MP, et al. Language disturbance. An initial symptom of cortical degenerations and dementia. Arch Neurol. May 1984;41(5):491-6. [Medline].

4. Neary D, Snowden J. Fronto-temporal dementia: nosology, neuropsychology, and neuropathology. Brain Cogn. Jul 1996;31(2):176-87. [Medline].

5. Josephs KA. Frontotemporal dementia and related disorders: deciphering the enigma. Ann Neurol. Jul 2008;64(1):4-14. [Medline].

6. Boxer AL, Miller BL. Clinical features of frontotemporal dementia. Alzheimer Dis Assoc Disord. Oct-Dec 2005;19 Suppl 1:S3-6. [Medline].

7. Stevens M, van Duijn CM, Kamphorst W, et al. Familial aggregation in frontotemporal dementia. Neurology. Jun 1998;50(6):1541-5. [Medline].

8. Westbury C, Bub D. Primary progressive aphasia: a review of 112 cases. Brain Lang. Dec 1997;60(3):381-406. [Medline].

9. Miller BL, Hou CE. Portraits of artists: emergence of visual creativity in dementia. Arch Neurol. Jun 2004;61(6):842-4. [Medline].

10. Gorno-Tempini ML, Dronkers NF, Rankin KP, et al. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. Mar 2004;55(3):335-46. [Medline].

11. Hodges JR, Patterson K, Oxbury S, et al. Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain. Dec 1992;115 (Pt 6):1783-806. [Medline].

12. Whitwell JL, Jack CR Jr, Senjem ML, et al. Patterns of atrophy in pathologically confirmed FTLD with and without motor neuron degeneration. Neurology. Jan 10 2006;66(1):102-4. [Medline].

13. Grossman M, Mickanin J, Onishi K. Progressive nonfluent aphasia: language, cognitive, and PET measures contrasted with probable Alzheimer's disease. J Cogn Neurosci. 1996;8:135-54.

14. Seelaar H, Kamphorst W, Rosso SM, et al. Distinct genetic forms of frontotemporal dementia. Neurology. Oct 14 2008;71(16):1220-6. [Medline].

15. Wilhelmsen KC. Frontotemporal dementia is on the MAPtau. Ann Neurol. Feb 1997;41(2):139-40. [Medline].

16. Mesulam MM, Johnson N, Grujic Z, et al. Apolipoprotein E genotypes in primary progressive aphasia. Neurology. Jul 1997;49(1):51-5. [Medline].

17. Tyrrell PJ, Warrington EK, Frackowiak RS, et al. Heterogeneity in progressive aphasia due to focal cortical atrophy. A clinical and PET study. Brain. Oct 1990;113 (Pt 5):1321-36. [Medline].

18. Holland AL, McBurney DH, Moossy J, et al. The dissolution of language in Pick's disease with neurofibrillary tangles: a case study. Brain Lang. Jan 1985;24(1):36-58. [Medline].

19. Wechsler AF, Verity MA, Rosenschein S, et al. Pick's disease. A clinical, computed tomographic, and histologic study with golgi impregnation observations. Arch Neurol. May 1982;39(5):287-90. [Medline].

20. Graff-Radford NR, Damasio AR, Hyman BT, et al. Progressive aphasia in a patient with Pick's disease: a neuropsychological, radiologic, and anatomic study. Neurology. Apr 1990;40(4):620-6. [Medline].

21. Kirshner HS, Tanridag O, Thurman L, et al. Progressive aphasia without dementia: two cases with focal spongiform degeneration. Ann Neurol. Oct 1987;22(4):527-32. [Medline].

22. Morris JC, Cole M, Banker BQ, et al. Hereditary dysphasic dementia and the Pick-Alzheimer spectrum. Ann Neurol. Oct 1984;16(4):455-66. [Medline].

23. Josephs KA, Whitwell JL, Duffy JR, et al. Progressive aphasia secondary to Alzheimer disease vs FTLD pathology. Neurology. Jan 1 2008;70(1):25-34. [Medline].

24. Kertesz A, Munoz DG. Primary progressive aphasia and Pick complex. J Neurol Sci. Jan 15 2003;206(1):97-107. [Medline].

25. Abe K, Ukita H, Yanagihara T. Imaging in primary progressive aphasia. Neuroradiology. Aug 1997;39(8):556-9. [Medline].

26. Alladi S, Xuereb J, Bak T, et al. Focal cortical presentations of Alzheimer's disease. Brain. Oct 2007;130:2636-45. [Medline].

27. Baker M, Mackenzie IR, Pickering-Brown SM, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. Aug 24 2006;442(7105):916-9. [Medline].

28. Bird TD. Genotypes, phenotypes, and frontotemporal dementia: take your pick. Neurology. Jun 1998;50(6):1526-7. [Medline].

29. Black SE. Focal cortical atrophy syndromes. Brain Cogn. Jul 1996;31(2):188-229. [Medline].

30. Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups. J Neurol Neurosurg Psychiatry. Apr 1994;57(4):416-8. [Medline].

31. Davies RR, Hodges JR, Kril JJ, et al. The pathological basis of semantic dementia. Brain. Sep 2005;128:1984-95. [Medline].

32. Diehl J, Grimmer T, Drzezga A, et al. Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study. Neurobiol Aging. Sep 2004;25(8):1051-6. [Medline].

33. Edwards-Lee T, Miller BL, Benson DF, et al. The temporal variant of frontotemporal dementia. Brain. Jun 1997;120 (Pt 6):1027-40. [Medline].

34. Forman MS, Farmer J, Johnson JK, et al. Frontotemporal dementia: clinicopathological correlations. Ann Neurol. Jun 2006;59(6):952-62. [Medline].

35. Forman MS, Mackenzie IR, Cairns NJ, et al. Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol. Jun 2006;65(6):571-81. [Medline].

36. Geschwind D, Karrim J, Nelson SF, et al. The apolipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia. Ann Neurol. Jul 1998;44(1):134-8. [Medline].

37. Gorno-Tempini ML, Brambati SM, Ginex V, et al. The logopenic/phonological variant of primary progressive aphasia. Neurology. Oct 14 2008;71(16):1227-34. [Medline].

38. Graham NL, Bak T, Patterson K, et al. Language function and dysfunction in corticobasal degeneration. Neurology. Aug 26 2003;61(4):493-9. [Medline].

39. Green J, Morris JC, Sandson J, et al. Progressive aphasia: a precursor of global dementia?. Neurology. Mar 1990;40(3 Pt 1):423-9. [Medline].

40. Gustafson L, Abrahamson M, Grubb A, et al. Apolipoprotein-E genotyping in Alzheimer's disease and frontotemporal dementia. Dement Geriatr Cogn Disord. Jul-Aug 1997;8(4):240-3. [Medline].

41. Heutink P, Stevens M, Rizzu P, et al. Hereditary frontotemporal dementia is linked to chromosome 17q21-q22: a genetic and clinicopathological study of three Dutch families. Ann Neurol. Feb 1997;41(2):150-9. [Medline].

42. Hodges JR, Davies RR, Xuereb JH, et al. Clinicopathological correlates in frontotemporal dementia. Ann Neurol. Sep 2004;56(3):399-406. [Medline].

43. Huey ED, Putnam KT, Grafman J. A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia. Neurology. Jan 10 2006;66(1):17-22. [Medline].

44. Josephs KA, Holton JL, Rossor MN, et al. Neurofilament inclusion body disease: a new proteinopathy?. Brain. Oct 2003;126:2291-303. [Medline].

45. Josephs KA, Petersen RC, Knopman DS, et al. Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology. Jan 10 2006;66(1):41-8. [Medline].

46. Kersaitis C, Halliday GM, Xuereb JH, et al. Ubiquitin-positive inclusions and progression of pathology in frontotemporal dementia and motor neurone disease identifies a group with mainly early pathology. Neuropathol Appl Neurobiol. Feb 2006;32(1):83-91. [Medline].

47. Kertesz A. Frontotemporal dementia/Pick's disease. Arch Neurol. Jun 2004;61(6):969-71. [Medline].

48. Kertesz A, Hudson L, Mackenzie IR, et al. The pathology and nosology of primary progressive aphasia. Neurology. Nov 1994;44(11):2065-72. [Medline].

49. Kertesz A, Martinez-Lage P, Davidson W, et al. The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology. Nov 14 2000;55(9):1368-75. [Medline].

50. Kertesz A, McMonagle P, Blair M, et al. The evolution and pathology of frontotemporal dementia. Brain. Sep 2005;128:1996-2005. [Medline].

51. Lebert F, Stekke W, Hasenbroekx C, et al. Frontotemporal dementia: a randomised, controlled trial with trazodone. Dement Geriatr Cogn Disord. 2004;17(4):355-9. [Medline].

52. Lippa CF, Cohen R, Smith TW, et al. Primary progressive aphasia with focal neuronal achromasia. Neurology. Jun 1991;41(6):882-6. [Medline].

53. Mesulam MM. Primary progressive aphasia--a language-based dementia. N Engl J Med. Oct 16 2003;349(16):1535-42. [Medline].

54. Mesulam MM. Primary progressive aphasia. Ann Neurol. Apr 2001;49(4):425-32. [Medline].

55. Moretti R, Torre P, Antonello RM, et al. Frontotemporal dementia: paroxetine as a possible treatment of behavior symptoms. A randomized, controlled, open 14-month study. Eur Neurol. 2003;49(1):13-9. [Medline].

56. Mott RT, Dickson DW, Trojanowski JQ, et al. Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias. J Neuropathol Exp Neurol. May 2005;64(5):420-8. [Medline].

57. Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. Dec 1998;51(6):1546-54. [Medline].

58. Neary D, Snowden JS, Mann DM, et al. Frontal lobe dementia and motor neuron disease. J Neurol Neurosurg Psychiatry. Jan 1990;53(1):23-32. [Medline].

59. Sakurai Y, Hashida H, Uesugi H, et al. A clinical profile of corticobasal degeneration presenting as primary progressive aphasia. Eur Neurol. 1996;36(3):134-7. [Medline].

60. Seeley WW, Bauer AM, Miller BL, et al. The natural history of temporal variant frontotemporal dementia. Neurology. Apr 26 2005;64(8):1384-90. [Medline].

61. Snowden J, Neary D, Mann D. Frontotemporal lobar degeneration: clinical and pathological relationships. Acta Neuropathol. Jul 2007;114(1):31-8. [Medline].

62. Sonty SP, Mesulam MM, Thompson CK, et al. Primary progressive aphasia: PPA and the language network. Ann Neurol. Jan 2003;53(1):35-49. [Medline].

63. Weintraub S, Rubin NP, Mesulam MM. Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features. Arch Neurol. Dec 1990;47(12):1329-35. [Medline].

Further Reading

Keywords

frontotemporal dementia, frontal dementia, semantic dementia, nonspecific dementia, Pick's disease, Pick disease, primary progressive aphasia, FTD, PPA, tauopathy, motor neuron disease, Alzheimer disease, Alzheimer's disease, AD, fluent aphasia, nonfluent aphasia

Contributor Information and Disclosures

Author

Howard S Kirshner, MD, Professor of Neurology, Psychiatry and Hearing and Speech Sciences, Vice Chairman, Department of Neurology, Vanderbilt University School of Medicine; Director, Vanderbilt Stroke Center; Program Director, Stroke Service, Vanderbilt Stallworth Rehabilitation Hospital; Consulting Staff, Department of Neurology, Nashville Veterans Affairs Medical Center
Howard S Kirshner, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Neurology, American Heart Association, American Medical Association, American Neurological Association, American Society of Neurorehabilitation, National Stroke Association, Phi Beta Kappa, and Tennessee Medical Association
Disclosure: Boehringer Ingelheim Honoraria Speaking and teaching; BMS/Sanofi Honoraria Speaking and teaching; Novartis Honoraria Speaking and teaching

Medical Editor

Robert A Hauser, MD, MBA, Professor of Neurology, Molecular Pharmacology and Physiology, Director, Parkinson's Disease and Movement Disorders Center, University of South Florida; Clinical Chair, Signature Interdisciplinary Program in Neuroscience
Robert A Hauser, MD, MBA is a member of the following medical societies: American Academy of Neurology, American Medical Association, American Society of Neuroimaging, and Movement Disorders Society
Disclosure: Allergan Sales, LLC Honoraria Speaking and teaching; Bayer Shering Pharma AG Honoraria Consulting; Boehringer Ingelheim France Honoraria Consulting; Centapharm Honoraria Speaking and teaching; Genzyme Corporation Honoraria Consulting; GlaxoSmithKline Honoraria Consulting; IMPAX Laboratories, Inc.  Consulting; Kyowa Pharmaceuticals, Inc. Honoraria Consulting; Novartis Pharmaceuticals Corp. Honoraria Consulting; Prestwick Pharmaceuticals, Inc. Honoraria Consulting

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
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Managing Editor

Richard J Caselli, MD, Professor, Department of Neurology, Mayo Medical School, Rochester, MN; Chair, Department of Neurology, Mayo Clinic of Scottsdale
Richard J Caselli, MD is a member of the following medical societies: American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, American Medical Association, American Neurological Association, and Sigma Xi
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CME Editor

Matthew J Baker, MD, Consulting Staff, Collier Neurologic Specialists, Naples Community Hospital
Matthew J Baker, MD is a member of the following medical societies: American Academy of Neurology
Disclosure: Nothing to disclose.

Chief Editor

Howard A Crystal, MD, Professor, Departments of Neurology and Pathology, State University of New York Downstate; Consulting Staff, Department of Neurology, University Hospital and Kings County Hospital Center
Howard A Crystal, MD is a member of the following medical societies: American Academy of Neurology and American Neurological Association
Disclosure: Medivations Honoraria Consulting